prenylamine
- CAS No.
- 390-64-7
- Chemical Name:
- prenylamine
- Synonyms
- B-436;Corpax;Elecor;Segontin;Carditin;Bismethin;SAN 13-194;Hostaginan;prenylamine;Sandoz 13-194
- CBNumber:
- CB8875291
- Molecular Formula:
- C24H27N
- Molecular Weight:
- 329.47788
- MDL Number:
- MFCD00242807
- MOL File:
- 390-64-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Prenylamine | 29430 | 10mg | $84 |
| Prenylamine | 29430 | 100mg | $680 |
| Prenylamine | 29430 | 5mg | $44 |
| Prenylamine | 29430 | 50mg | $384 |
| Prenylamine | P712800 | 25mg | $135 |
| More product size | |||
| Melting point | 36.5-37.5° |
|---|---|
| Boiling point | 457.06°C (rough estimate) |
| Density | 1.0703 (rough estimate) |
| refractive index | 1.9000 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform: slightly soluble; Methanol: slightly soluble |
| form | A solid |
| pka | pKa 8.74±0.02(40% EtOH,t =25) (Uncertain) |
| color | Light yellow to yellow |
| Water Solubility | 50mg/L(37 ºC) |
| FDA UNII | K2OH82Z000 |
| ATC code | C01DX02,C01DX52 |
prenylamine price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29430 | Prenylamine | 390-64-7 | 10mg | $84 | 2024-03-01 | Buy |
| Cayman Chemical | 29430 | Prenylamine | 390-64-7 | 100mg | $680 | 2024-03-01 | Buy |
| Cayman Chemical | 29430 | Prenylamine | 390-64-7 | 5mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 29430 | Prenylamine | 390-64-7 | 50mg | $384 | 2024-03-01 | Buy |
| TRC | P712800 | Prenylamine | 390-64-7 | 25mg | $135 | 2021-12-16 | Buy |
prenylamine Chemical Properties,Uses,Production
Description
Prenylamine is a calcium channel inhibitor. It inhibits the plasma membrane Ca2+ ATPase (PMCA) in isolated and purified pig cardiac sarcolemma. It binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 μM and inhibits CaM-activated cAMP phosphodiesterase (PDE) activity when used at concentrations ranging from 10 to 50 μM, an effect that is negatively associated with the concentration of calmodulin. Prenylamine (30 μM) shortens action potential duration and decreases the amplitude of peak calcium currents in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine . Prenylamine (50 mg/kg) decreases epinephrine, serotonin, and dopamine levels in rat brain. It also decreases epinephrine levels in rat heart. It protects anesthetized rats from coronary artery occlusion-induced arrhythmia when administered at a dose of 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole when administered at a dose of 5 mg/kg.
Chemical Properties
Pale Yellow Oil
Uses
Vasodilator (coronary).
Definition
ChEBI: Prenylamine is a diarylmethane.
World Health Organization (WHO)
Prenylamine is a calcium-channel blocking agent which was introduced in 1960. It has been widely used for the prophylaxis of angina pectoris and long-term treatment of coronary heart disease. Concern about its propensity to induce dangerous cardiac dysrhythmias led the company to withdraw it from the market.
References
[1] R BAYER R P J Schwarzmaier. Basic mechanisms underlying prenylamine-induced “torsade de pointes”: differences between prenylamine and fendiline due to basic actions of the isomers.[J]. Current Medical Research and Opinion, 1988, 11 4: 254-272. DOI: 10.1185/03007998809114244
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] J D JOHNSON L A W. A fluorescent calmodulin that reports the binding of hydrophobic inhibitory ligands.[J]. Biochemical Journal, 1983, 211 2: 473-479. DOI: 10.1042/bj2110473
[4] Y. SHIMONI. The effects of prenylamine on single ventricular myocytes of guinea-pig[J]. British Journal of Pharmacology, 1988, 94 2: 319-324. DOI: 10.1111/j.1476-5381.1988.tb11533.x
[5] OBIANWU H O. The effect of prenylamine (segontin) on the amine levels of brain, heart and adrenal medulla in rats.[J]. Acta pharmacologica et toxicologica, 1965, 23 4: 383-390. DOI: 10.1111/j.1600-0773.1965.tb00362.x
[6] O FAGBEMI. The effects of verapamil, prenylamine, flunarizine and cinnarizine on coronary artery occlusion-induced arrhythmias in anaesthetized rats.[J]. British Journal of Pharmacology, 1984, 83 1: 299-304. DOI: 10.1111/j.1476-5381.1984.tb10146.x
prenylamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18333 | 56 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | cindy.yang@lgcgroup.com | China | 18003 | 58 |
| Shaanxi Xihua Chemical Industry Co., Ltd | 029-81136151 17392212881 | 1095@dideu.com | China | 9993 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Cellosaurus STR | 13121892008 | cellosaurus@sib.swiss | China | 6968 | 58 |
