fenspiride
- CAS No.
- 5053-06-5
- Chemical Name:
- fenspiride
- Synonyms
- DESP;FUBMN24;FUB-MN24;Fenspirid;fenspiride;Fenspiridum;Fenspiride-d5;fenspiride USP/EP/BP;8-phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one;Pharmaceutical intermediates BKEDBP BKEDBP bkedbp
- CBNumber:
- CB8875352
- Molecular Formula:
- C15H20N2O2
- Molecular Weight:
- 260.33
- MDL Number:
- MFCD00867054
- MOL File:
- 5053-06-5.mol
| Boiling point | 126-127 °C(Press: 2 Torr) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| pka | 12.44±0.20(Predicted) |
| form | Solid:particulate/powder |
| LogP | 1.798-1.802 at 20℃ and pH6 |
| FDA UNII | S983QC7HKM |
| ATC code | R03BX01,R03DX03 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H412-H302-H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P273-P501 |
fenspiride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | S040 | Fenspiride | 5053-06-5 | 1g | $384 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | RDL0006831 | FENSPIRIDE-D5 95.00% | 5053-06-5 | 5MG | $500.31 | 2021-12-16 | Buy |
| AK Scientific | S040 | Fenspiride | 5053-06-5 | 5g | $1051 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | D74913 | Fenspiride-d5 | 5053-06-5 | 5mg | $1490 | 2021-12-16 | Buy |
| Chemenu | CM124411 | 8-phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one 97% | 5053-06-5 | 1g | $351 | 2021-12-16 | Buy |
fenspiride Chemical Properties,Uses,Production
Originator
Viarespan,Servier,France,1969
Uses
Bronchodilator;anti-adrenergic (β-receptor).
Definition
ChEBI: 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one is an azaspiro compound.
Manufacturing Process
A solution of 192 g of 1-phenethyl-4-hydroxy-4-aminomethyl piperidine in 800
cc of diethylcarbonate is heated for 2? hours to reflux at about 80°C in the
presence of sodium methylate (prepared for immediate use from 2 g of
sodium). After this time, the ethyl alcohol formed during the reaction is slowly
distilled while the maximum temperature is reached. The excess ethyl
carbonate is distilled under reduced pressure. A crystallized residue is then
obtained, which is stirred with 400 cc of water and 400 cc of ether. The
solution is filtered and 125 g (77.6%) of practically pure product melting at
232°C to 233°C, are obtained.
The starting material was prepared in a yield of 58% by reduction of the
corresponding cyanohydrin. It in turn was prepared from 1-(2-phenylethyl)-4-
piperidone and potassium cyanide to give the cyanohydrin which was reduced
by lithium aluminum hydride.
Therapeutic Function
Bronchodilator
Pharmaceutical Applications
Fenspiride is an antagonist of 5-hydroxytryptamine, whose effect on bronchial smooth muscle expansion is between isoproterenol and theophylline. It also has the effect of unobtrusion-free respiratory tract and air resistance elimination in the lungs. It has the effect of antitussive, antipyretic, analgesic and anti-inflammatory, and the antipyretic and analgesic effect is better than aminopyrine and the anti-inflammatory effect is stronger than bute.
fenspiride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 | info@pharmachemm.com | China | 222 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Casorganics US Corp | +17326109938 | sales@casorganics.com | CHINA | 174 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3422 | 58 |
| Hebei Miaobian Biotechnology Co., Ltd | +8617733850068 | CHINA | 979 | 58 |
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View Lastest Price from fenspiride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-06-28 | Fenspiride
5053-06-5
|
US $50.00 / kg | 1kg | 99.9% | 10000MT | Henan Bao Enluo International TradeCo.，LTD | |
 |
2023-02-13 | Fenspiride
5053-06-5
|
US $10.00 / kg | 1kg | 99% | 50MT | Hebei baicao biology science and technology co., ltd | |
 |
2022-05-13 | fenspiride
5053-06-5
|
US $1.10 / g | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited |
-
- Fenspiride
5053-06-5
- US $50.00 / kg
- 99.9%
- Henan Bao Enluo International TradeCo.，LTD
-
- Fenspiride
5053-06-5
- US $10.00 / kg
- 99%
- Hebei baicao biology science and technology co., ltd
-
- fenspiride
5053-06-5
- US $1.10 / g
- 99.0% Min
- Dideu Industries Group Limited
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