(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
- CAS No.
- 38396-39-3
- Chemical Name:
- (±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
- Synonyms
- Bupivacaina;Bucain;Ah 250;Bupivan;Rac-Bupivacaine;Bupivacaine Free Base;Bupivacaine (SKY 0402);Bupivacaine Base (IHS);(R,S)-Bupivqacaine hydrochloride;BUPIVACAINE FREE BASEBUPIVACAINE FREE BASE
- CBNumber:
- CB8897837
- Molecular Formula:
- C18H28N2O
- Molecular Weight:
- 288.43
- MDL Number:
- MFCD00243007
- MOL File:
- 38396-39-3.mol
- MSDS File:
- SDS
| Melting point | 106-110℃ |
|---|---|
| Boiling point | 423.4±45.0 °C(Predicted) |
| Density | 1.032±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:25.0(Max Conc. mg/mL);86.68(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);104.01(Max Conc. mM) Ethanol:30.0(Max Conc. mg/mL);104.01(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.73(Max Conc. mM) |
| form | Cyrstalline powder |
| pka | 14.85±0.70(Predicted) |
| Water Solubility | Soluble in water, ethanol, chloroform (slightly ), and acetone (slightly ). |
| FDA UNII | Y8335394RO |
| EPA Substance Registry System | 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)- (38396-39-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H310-H330 | |||||||||
| Precautionary statements | P301+P310a-P304+P340-P320-P330-P405-P501a | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| NFPA 704 |
|
(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J62742 | Bupivacaine | 38396-39-3 | 1g | $155.65 | 2024-03-01 | Buy |
| Alfa Aesar | J62742 | Bupivacaine | 38396-39-3 | 5g | $262.65 | 2024-03-01 | Buy |
| Cayman Chemical | 16618 | Bupivacaine ≥98% | 38396-39-3 | 1g | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 16618 | Bupivacaine ≥98% | 38396-39-3 | 5g | $68 | 2024-03-01 | Buy |
| Alfa Aesar | J62742 | Bupivacaine | 38396-39-3 | 25g | $1158 | 2024-03-01 | Buy |
(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical Properties,Uses,Production
Description
Bupivacaine is a sodium channel blocker and local anesthetic. It inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner and inhibits synaptic transmission in rat sympathetic ganglia, increasing the firing threshold when used at a concentration of 200 nM. Bupivacaine (10 μM) blocks cardiac sodium channels in a use-dependent manner and inhibits respiration in cardiac cell mitochondria when palmitoyl-carnitine or acetyl-carnitine are used as substrates (IC50s = 0.78 and 0.37 mM, respectively). It also reduces thermal hyperplasia in a rat model of sciatic ligation injury when 0.6 ml of a 0.5% solution is administered into the perinerve space, and the duration of this effect is extended by co-administration of the NMDA receptor antagonist MK-801 . Formulations containing bupivacaine have been used as local anesthetics for surgery, oral surgery, and dental procedures and for anesthetic purposes in research studies using animals.
Uses
Bupivacaine acts as a potent and long-acting local anesthetic agent in vivo. At 100 μM, it has been reported to inhibit the uptake of dopamine in striatal synaptosomes by 47%.
Definition
ChEBI: A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
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| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
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| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
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