ChemicalBook >> CAS DataBase List >>8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
![8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid Structure](CAS/GIF/145-63-1.gif)
- CAS No.
- 145-63-1
- Chemical Name:
- 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
- Synonyms
- Naganil;Fourneau;Suramine;Naphuride;Farma 939;Aids000067;Aids-000067;129-46-4(Hexasodium salt);8,8-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid;8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid
- CBNumber:
- CB8906847
- Molecular Formula:
- C51H40N6O23S6
- Molecular Weight:
- 1297.28
- MDL Number:
- MFCD00242612
- MOL File:
- 145-63-1.mol
- MSDS File:
- SDS
Last updated:2023-05-21 10:59:17
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid Properties
| Melting point | 128 °C(Solv: ethyl ether (60-29-7)) |
|---|---|
| Density | 1.2629 (rough estimate) |
| refractive index | 1.7770 (estimate) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | -1.35±0.40(Predicted) |
| color | Pinkish-white, hygroscopic powder |
| FDA UNII | 6032D45BEM |
| EPA Substance Registry System | Suramin (145-63-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P305+P351+P338 |
| Toxicity | LD50 intravenous in mouse: 620mg/kg |
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0004298 | SURAMIN 95.00% | 145-63-1 | 50MG | $692.73 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004298 | SURAMIN 95.00% | 145-63-1 | 250MG | $1042.6 | 2021-12-16 | Buy |
| Chemtos | S-6954 | Suramind12sodium | 145-63-1 | 10mg | $1990 | 2021-12-16 | Buy |
| Crysdot | CD31003423 | Suramin 98+% | 145-63-1 | 50mg | $54 | 2021-12-16 | Buy |
| CSNpharm | CSN17880 | Suramin | 145-63-1 | 10mg | $56 | 2021-12-16 | Buy |
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid Chemical Properties,Uses,Production
Definition
ChEBI: Suramin is a member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. It has a role as a ryanodine receptor agonist, a GABA-gated chloride channel antagonist, a GABA antagonist, an apoptosis inhibitor, an antineoplastic agent, an angiogenesis inhibitor, a purinergic receptor P2 antagonist, an EC 2.7.11.13 (protein kinase C) inhibitor, an antinematodal drug and a trypanocidal drug. It is a member of phenylureas, a secondary carboxamide and a naphthalenesulfonic acid. It is functionally related to a naphthalene-1,3,5-trisulfonic acid. It is a conjugate acid of a suramin(6-).
Safety Profile
Moderately toxic by intravenousroute. Human systemic effects by intravenous route: eyeeffects. An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits very toxic fumes of SOx and NOx.
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid Suppliers
Global( 21)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ENBRIDGE PHARMTECH CO., LTD. | +8613812269233 | tinayang@enbridgepharm.com | China | 303 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12990 | 57 | |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
View Lastest Price from 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Suramin
145-63-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Suramin
145-63-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
Farma 939
Fourneau
Naphuride
Suramine
129-46-4(Hexasodium salt)
8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid
Aids000067
Aids-000067
Naganil
1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis[iMino-3,1-phenylenecarbonyliMino(4-Methyl-3,1-phenylene)carbonyliMino]]bis-
8,8'-((3,3'-((3,3'-(carbonylbis(azanediyl))bis(benzoyl))bis(azanediyl))bis(4-Methylbenzoyl))bis(azanediyl))bis(naphthalene-1,3,5-trisulfonic acid)
8,8-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
145-63-1
C51H40N6O23S6