methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
- CAS No.
- 1601-18-9
- Chemical Name:
- methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
- Synonyms
- L 588983;Indometacin Impurity H;Indapamide EP Impurity H;Indomethacin Methyl Ester;Indometacin EP Impurity H;Indomethacin EP Impurity H;Methyl 2-(1-(4-chlorobenzoyl);Methyl [1-(4-Chlorobenzoyl)-5-metho;Indomethacin Impurity 8(Indomethacin EP Impurity H);Methyl N-(p-Chlorobenzoyl)-2-Methyl-5-Methoxy-3-indolylacetate
- CBNumber:
- CB8912958
- Molecular Formula:
- C20H18ClNO4
- Molecular Weight:
- 371.81
- MDL Number:
- MFCD01719291
- MOL File:
- 1601-18-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| IndomethacinMethylEster | I641025 | 5mg | $65 |
| Indomethacin methyl ester | 280435 | 5mg | $403 |
| METHYL1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETATE | 2702AQ | 1g | $372.8 |
| METHYL 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETATE 95.00% | HCH0173717 | 5MG | $505.75 |
| methyl2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate 98% | 61-6006 | 0.25g | $1000 |
| More product size | |||
| Melting point | 99-100 °C |
|---|---|
| Boiling point | 463.4±45.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly) |
| form | Solid |
| color | Pale Yellow to Light Green |
| FDA UNII | V7N8G32K46 |
| NIST Chemistry Reference | Indomethacin, methyl ester(1601-18-9) |
methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | I641025 | IndomethacinMethylEster | 1601-18-9 | 5mg | $65 | 2021-12-16 | Buy |
| Usbiological | 280435 | Indomethacin methyl ester | 1601-18-9 | 5mg | $403 | 2021-12-16 | Buy |
| AK Scientific | 2702AQ | METHYL1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETATE | 1601-18-9 | 1g | $372.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0173717 | METHYL 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETATE 95.00% | 1601-18-9 | 5MG | $505.75 | 2021-12-16 | Buy |
| Abosyn | 61-6006 | methyl2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate 98% | 1601-18-9 | 0.25g | $1000 | 2021-12-16 | Buy |
methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate Chemical Properties,Uses,Production
Chemical Properties
Pale Green Solid
Uses
Selective COX-2 inhibitor
Synthesis
67-56-1
53-86-1
1601-18-9
GENERAL METHOD: 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid (1 eq.) and BOP-Cl (1 eq.) were suspended in dichloromethane (20 mL/g of acid), triethylamine (2 eq.) was added slowly and the mixture was stirred for 10 minutes. Methanol (4 eq.) was then added and the reaction mixture continued to be stirred for at least 12 hours. Upon completion of the reaction, the solvent was removed by evaporation and the resulting solid was purified by column chromatography with the eluent being a solvent mixture of hexane and ethyl acetate (3:1, v/v) at a boiling range of 80-100°C. Finally, the solvent was removed under reduced pressure to give methyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate as a light yellow solid.
References
[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 15, p. 4830 - 4837
[2] Pharmazie, 2003, vol. 58, # 2, p. 99 - 103
[3] Patent: CN105418480, 2016, A. Location in patent: Paragraph 0031
[4] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 3, p. 745 - 762
[5] European Journal of Pharmaceutical Sciences, 2001, vol. 14, # 4, p. 301 - 311
methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Compound Net Biotechnology Inc. | +8615303909093 | sales@compound-net.com | China | 2914 | 58 |
| Sinco Pharmachem (ShenZhen) R&D Co., Ltd. | +undefined18603013401 | jack.lin@sincopharmachem.com | China | 9996 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-10-22 | methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
1601-18-9
|
US $0.01 / KG | 1KG | 95%-99% | 1kg; 5kg; 10kg | Career Henan Chemica Co |
-
- methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
1601-18-9
- US $0.01 / KG
- 95%-99%
- Career Henan Chemica Co
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