Dexamethasone sodium phosphate EP Impurity B
- CAS No.
- 360-63-4
- Chemical Name:
- Dexamethasone sodium phosphate EP Impurity B
- Synonyms
- Unii-yjo1F9W10r;Einecs 206-636-7;Betamethasone phosphate;Betamethasone 21-phosphate;Betamethasone 21-phopsphate;Dexamethasone Impurity B(EP);Betamethasone dihydrogen phosphate;Betamethasone 21-(dihydrogen phosphate);Betamethasone Sodium Phosphate Impurity 3;Betamethasone-4,6,11,12,12-d5 21-Phosphate
- CBNumber:
- CB8939872
- Molecular Formula:
- C22H30FO8P
- Molecular Weight:
- 472.44
- MDL Number:
- MFCD01698987
- MOL File:
- 360-63-4.mol
| FDA UNII | YJO1F9W10R |
|---|
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H410-H372-H360 |
| Precautionary statements | P260-P264-P270-P314-P501-P273-P391-P501 |
Dexamethasone sodium phosphate EP Impurity B Chemical Properties,Uses,Production
Originator
Bentelan,Biofutura
Uses
Glucocorticoid.
Definition
ChEBI: Betamethasone phosphate is a steroid phosphate that is the 21-O-phospho derivative of betamethasone. It has a role as an anti-inflammatory agent and an immunosuppressive agent. It is a steroid phosphate, an 11beta-hydroxy steroid, a fluorinated steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a betamethasone. It is a conjugate acid of a betamethasone phosphate(2-).
Manufacturing Process
A solution of bistriethylamine phosphate was prepared by slowly adding 2.36
ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml, of
triethylamine at 20°C. This solution was added to a stirred mixture of 4.70 g
of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
21-methanesulfonate and 20 ml of acetonitrile. The mixture was heated under
reflux for 4 h and then evaporated under reduced pressure to a volume of 12
ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21-
trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate
triethylamine salt with some inorganic phosphate.
The salt of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-
3,20-dione 21-phosphate may be converted to 9α-fluoro-11β,17α,21-
trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate by
treatment with acid (for example HCl).
brand name
Celestone (Schering).
Therapeutic Function
Glucocorticoid
Dexamethasone sodium phosphate EP Impurity B Preparation Products And Raw materials
Raw materials
Preparation Products
Dexamethasone sodium phosphate EP Impurity B Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +8613627253706 | sale@hdimpurity.com | China | 1504 | 58 |
| Nanjing MeiBo Biological Technology Co., Ltd. | 025-58619198 | sales@mbbio.com | China | 319 | 60 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9901 | 58 | |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| PI & PI BIOTECH INC. | 020-81716320 17788709170 | Sales@pipitech.com | China | 2649 | 58 |
| TOSUN PHARM | 020-61855200 13326451905 | 2881290884@qq.com | China | 7481 | 58 |
| Shanghai Keke Biotechnology Co., Ltd. | 021-34975789 18721102763 | click@click-biotech.com | China | 306 | 58 |
| Hefei fuya biotechnology co. LTD | 18096409024 | sales02@foreversyn.com | China | 1938 | 58 |
360-63-4(Dexamethasone sodium phosphate EP Impurity B)Related Search:
1of4