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PROTAC BRD4 Degrader-10

PROTAC BRD4 Degrader-10 structure

CAS No.: 2417370-49-9

Chemical Name:: PROTAC BRD4 Degrader-10

Synonyms: PROTAC BRD4 Degrader-10

CBNumber:: CB89633065

Molecular Formula:: C59H71F2N9O15S4

Molecular Weight:: 1312.51

MDL Number:

MOL File:: 2417370-49-9.mol

Last updated:2025-04-18 09:52:57

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PROTAC BRD4 Degrader-10 Properties

Boiling point	1397.9±65.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
pka	13.54±0.46(Predicted)
form	Solid
color	Off-white to light yellow

PROTAC BRD4 Degrader-10 Chemical Properties,Uses,Production

Uses

PROTAC BRD4 Degrader-10 (compound 8b) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 1.3 nM and 18 nM, respectively[1].

References

[1] Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607. DOI:10.1021/acs.jmedchem.0c01846

PROTAC BRD4 Degrader-10 Preparation Products And Raw materials

Raw materials

Preparation Products

PROTAC BRD4 Degrader-10 Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	021-59167510 18117107507	vip@med-life.cn	China	5002	58

Supplier	Advantage
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	58

PROTAC BRD4 Degrader-10 2417370-49-9