BTO-1
- CAS No.
- 40647-02-7
- Chemical Name:
- BTO-1
- Synonyms
- BTO-1;Polo-like Kinase Inhibitor II, BTO-1;5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide;2-Benzothiazolecarboxamide, 5-cyano-7-nitro-, 3-oxide;Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem
- CBNumber:
- CB8972299
- Molecular Formula:
- C9H4N4O4S
- Molecular Weight:
- 264.22
- MDL Number:
- MFCD11045282
- MOL File:
- 40647-02-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| BTO-1 ≥98% (HPLC), solid | B6311 | 5mg | $176 |
| Polo-like Kinase Inhibitor II, BTO-1 | 528283 | 2mg | $242 |
| BTO-1 ≥98% (HPLC), solid | B6311 | 25mg | $526 |
| BTO-1 | B694340 | 2mg | $105 |
| BTO-1 | B694340 | 4mg | $165 |
| Boiling point | 553.0±60.0 °C(Predicted) |
|---|---|
| Density | 1.89±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: <2ML/mL |
| pka | 14.67±0.30(Predicted) |
| form | solid |
| color | tan |
| Water Solubility |
H2O: <2mL/mL DMSO: ≥5mg/mL |
| InChI | 1S/C9H4N4O4S/c10-3-4-1-5-7(6(2-4)13(16)17)18-9(8(11)14)12(5)15/h1-2H,(H2,11,14) |
| InChIKey | FKRBAXZAJBBIAJ-UHFFFAOYSA-N |
| SMILES | NC(=O)c1sc2c(cc(cc2[n+]1[O-])C#N)[N+]([O-])=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
BTO-1 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B6311 | BTO-1 ≥98% (HPLC), solid | 40647-02-7 | 5mg | $176 | 2026-04-30 | Buy |
| Sigma-Aldrich | 528283 | Polo-like Kinase Inhibitor II, BTO-1 | 40647-02-7 | 2mg | $242 | 2026-04-30 | Buy |
| Sigma-Aldrich | B6311 | BTO-1 ≥98% (HPLC), solid | 40647-02-7 | 25mg | $526 | 2026-04-30 | Buy |
| TRC | B694340 | BTO-1 | 40647-02-7 | 2mg | $105 | 2021-12-16 | Buy |
| TRC | B694340 | BTO-1 | 40647-02-7 | 4mg | $165 | 2021-12-16 | Buy |
BTO-1 Chemical Properties,Uses,Production
Uses
BTO-1 is a benzothiazolo-N-oxide Plk1 inhibitor.
General Description
A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC50 = 8.0 μM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 μM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring.
Biochem/physiol Actions
BTO-1 is a polo-like kinase (Plk) inhibitor.
IC 50
Plx1
BTO-1 Preparation Products And Raw materials
Raw materials
Preparation Products
BTO-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24957 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 6206333 13167063860 | anhua.mao@aladdin-e.com | China | 49998 | 58 |
| Merck Millipore | -- | bioscience@merckgroup.com | China | 6839 | 58 |
| Merck KGaA | -- | ordercn@merckgroup.com | China | 6394 | 58 |
| Santa Cruz Biotechnology Inc | -- | scbt@scbt.com | China | 6594 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| Aladdin Scientific | 58 |
| Sigma-Aldrich | 80 |
| TargetMol Chemicals Inc. | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 58 |
| Merck Millipore | 58 |
| Merck KGaA | 58 |
| Santa Cruz Biotechnology Inc | 58 |
