NS8593 HYDROCHLORIDE
- CAS No.
- 875755-24-1
- Chemical Name:
- NS8593 HYDROCHLORIDE
- Synonyms
- NS8593;NS8593 HCl;NS8593 HYDROCHLORIDE;N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine;: N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride;NS8593 hydrochloride,inhibit,NS8593,neurological,Ca2+,Inhibitor,hIK,SK1,SK2,KcsA,Potassium Channel,NS-8593,SK3,hBK,neurons,NS-8593 hydrochloride,dopaminergic,NS 8593,channel
- CBNumber:
- CB8973069
- Molecular Formula:
- C17H17N3.ClH
- Molecular Weight:
- 299.803
- MDL Number:
- MFCD11045298
- MOL File:
- 875755-24-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Hazard statements | H413 |
|---|---|
| WGK Germany | 3 |
NS8593 HYDROCHLORIDE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 492031 | NS8593 An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels in a Ca2+-dependent manner. | 10MG | $196 | 2024-03-01 | Buy | |
| Sigma-Aldrich | N2538 | NS8593 hydrochloride ≥98% (HPLC), powder | 875755-24-1 | 5mg | $169 | 2022-05-15 | Buy |
| Sigma-Aldrich | N2538 | NS8593 hydrochloride ≥98% (HPLC), powder | 875755-24-1 | 25mg | $638 | 2022-05-15 | Buy |
| Cayman Chemical | 29774 | NS 8593 (hydrochloride) | 875755-24-1 | 1mg | $29 | 2024-03-01 | Buy |
| Cayman Chemical | 29774 | NS 8593 (hydrochloride) | 875755-24-1 | 25mg | $393 | 2024-03-01 | Buy |
NS8593 HYDROCHLORIDE Chemical Properties,Uses,Production
Description
NS 8593 is an inhibitory gating modifier of small-conductance calcium-activated potassium (KCa2/SK) channels (Kds = 0.42, 0.6, and 0.73 μM for KCa2.1/SK1, KCa2.2/SK2, and KCa2.3/SK3, respectively, in the presence of calcium) that decreases the calcium sensitivity of SK channels. It is selective for KCa2/SK channels over intermediate- (KCa3.1/IKCa1) and large-conductance (BK) potassium channels at 10 μM. NS 8593 induces relaxation of potassium- or acetylcholine chloride-precontracted isolated tracheal rings from wild-type mice (IC50s = 8.9 and 39.8 μM, respectively) or from mice in an ovalbumin-induced model of allergic asthma (IC50s = 16.4 and 32.2 μM, respectively). It inhibits aerosolized acetylcholine chloride-induced increases in respiratory system resistance in mice when administered as an aerosol at a dose of 500 μM. NS 8593 (5 mg/kg) decreases the duration of burst-pacing-induced atrial fibrillation in normotensive and spontaneously hypertensive rats.
Uses
NS8593 hydrochloride has been used to study its effect on the growth of MDA-MB-231 cells (M.D. Anderson and metastasis breast cancer cells).
Biochem/physiol Actions
The compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reversibly inhibited recombinant SK3-mediated currents (human and rat SK3) with potencies around 100 nM. NS8593 did not inhibit 125I-apamin binding. NS8593 decreased the calcium sensitivity by shifting the activation curve for Ca2+ to the right, only slightly affecting the maximal Ca2+-activated SK current. NS8593 inhibited all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+. NS8593 did not affect the calcium-activated potassium channels of intermediate and large conductance (hIK and hBK channels, respectively). NS8593-mediated inhibition was prevented in the presence of a high concentration of the positive modulator NS309.
storage
Store at +4°C
NS8593 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
NS8593 HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2987 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3538 | 58 |