ChemicalBook >> CAS DataBase List >>1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1)

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1)

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1) structure

CAS No.: 2253744-57-7

Chemical Name:: 1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1)

Synonyms: 1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1)

CBNumber:: CB89843541

Molecular Formula:: C20H21Cl3N8O3

Molecular Weight:: 527.79

MDL Number:

MOL File:: 2253744-57-7.mol

Last updated:2023-06-30 15:45:59

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1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1) Properties

solubility	Soluble to 10 mM in water and to 20 mM in DMSO

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1) Chemical Properties,Uses,Production

Description

TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.

storage

Desiccate at RT

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1) Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18488	58
Changzhou Ruikaijia polymer material Technology Co., LTD	3693241975	kairuijiabio@126.com	China	6526	58
https://hanhongsci.com/	021-54306202 18917919676	info@hanhongsci.com	China	29990	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.com	China	24246	58

Supplier	Advantage
Changzhou Bojia Biomedical Technology Co., Ltd.	58
Changzhou Ruikaijia polymer material Technology Co., LTD	58
https://hanhongsci.com/	58
TargetMol Chemicals Inc.	58

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1) 2253744-57-7 C20H21Cl3N8O3