ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
- CAS No.
- 850649-61-5
- Chemical Name:
- ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
- Synonyms
- Alogliptin;Trajenta;Alogliptin (SYR-322);ALOGLIPTINA;Axagliptin hydrate;ogL;Agelieting;ALOGLIPTINE;Alogliptin,98%;Unii-jhc049lo86
- CBNumber:
- CB91011068
- Molecular Formula:
- C18H21N5O2
- Molecular Weight:
- 339.39
- MDL Number:
- MFCD09833196
- MOL File:
- 850649-61-5.mol
- MSDS File:
- SDS
| Melting point | 127 - 129°C |
|---|---|
| Boiling point | 519.2±60.0 °C(Predicted) |
| Density | 1.342 |
| Flash point | 267.8℃ |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 9.89±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | JHC049LO86 |
| ATC code | A10BH04 |
| NCI Drug Dictionary | alogliptin |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 24/25 |
| RIDADR | 3077 |
| HS Code | 29335990 |
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A575425 | Alogliptin | 850649-61-5 | 100mg | $325 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA17319 | Alogliptin | 850649-61-5 | 250mg | $400 | 2021-12-16 | Buy |
| Ark Pharm | P000456262 | Alogliptin 98+% | 850649-61-5 | 5g | $426 | 2021-12-16 | Buy |
| ApexBio Technology | A4038 | Alogliptin(SYR-322) | 850649-61-5 | 100mg | $470 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb134884 | Alogliptin >99% | 850649-61-5 | 100mg | $510 | 2021-12-16 | Buy |
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Chemical Properties,Uses,Production
Description
Alogliptin is a dipeptidyl-peptidase IV (DPP-4) inhibitor that was approved in Japan in 2010 for treatment of type 2 diabetes, a disease in which insulin resistance and β-cell dysfunction lead to hyperglycemia. As islet function is lost, the severity of insulin resistance increases. The introduction of DPP-4 inhibitors has brought a novel class of insulinotropic agents for the treatment options available to type 2 diabetic patients. The therapeutic potential of glucagon-like peptide 1 (GLP-1), an incretin peptide, for the treatment of type 2 diabetes was realized in the 1990s. The insulinotropic effects of GLP-1 depend closely on glucose concentrations providing the possibility of glucose normalization without the risk of hypoglycemia. GLP-1 has other non-insulinotropic physiological actions that are advantageous. It suppresses glucagon secretion from a cells and slows gastric emptying, which contributes to satiety and to a slower passage and reabsorption of carbohydrates. GLP-1 also contributes to satiety via a central mechanism as a neurotransmitter with effects on the hypothalamus.
Chemical Properties
White Solid
Originator
Syrrx Inc. (now Takeda San Diego) (Japan)
Uses
Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.
Definition
ChEBI: A piperidine that is 3-methyl-2,4-dioxo-3,4-dihydropyrimidine carrying additional 2-cyanobenzyl and 3-aminopiperidin-1-yl groups at positions 1 and 2 respectively (the R-enantiomer). Used in the form of its benzoate salt for treatment of t pe 2 diabetes.
brand name
Nesina
Clinical Use
Dipeptidyl peptidase 4 inhibitor:
Treatment of type 2 diabetes in combination with
other therapies
target
DPP-4
Metabolism
Alogliptin does not undergo extensive metabolism. Two minor metabolites were detected following administration of an oral dose of [14C]-alogliptin, N-demethylated alogliptin, M-I (<1% of the parent compound), and N-acetylated alogliptin, M-II (<6% of the parent compound). M-I is an active metabolite and is a highly selective inhibitor of DPP-4 similar to alogliptin; M-II does not display any inhibitory activity towards DPP-4 or other DPP-related enzymes. In vitro data indicate that CYP2D6 and CYP3A4 contribute to the limited metabolism of alogliptin.
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 8095 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15933 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-16 | ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
850649-61-5
|
US $5.00-0.10 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-04-09 | Alogliptin
850649-61-5
|
US $1070.00 / KG | 1KG | 99% | 600KG | Shandong Luning Pharmaceutical Co., Ltd. | |
 |
2024-01-04 | Alogliptin
850649-61-5
|
US $0.00-0.00 / kg | 1kg | 99%，single impurity＜0.1 | 1 ton | Nanjing Fred Technology Co., Ltd |
-
- ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
850649-61-5
- US $5.00-0.10 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Alogliptin
850649-61-5
- US $1070.00 / KG
- 99%
- Shandong Luning Pharmaceutical Co., Ltd.
-
- Alogliptin
850649-61-5
- US $0.00-0.00 / kg
- 99%，single impurity＜0.1
- Nanjing Fred Technology Co., Ltd