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ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) structure
CAS No.
850649-61-5
Chemical Name:
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
Synonyms
ogL;Trajenta;Alogliptin;850649-61-5;ALOGLIPTINA;Alogliptin,98%;Unii-jhc049lo86;Trelagliptin-11;Axagliptin hydrate;Alogliptin (SYR-322)
CBNumber:
CB91011068
Molecular Formula:
C18H21N5O2
Formula Weight:
339.39
MOL File:
850649-61-5.mol

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Properties

Boiling point:
519.2±60.0 °C(Predicted)
Density 
1.342
Flash point:
267.8℃
pka
9.89±0.20(Predicted)
FDA UNII
JHC049LO86
NCI Drug Dictionary
alogliptin
SAFETY
  • Risk and Safety Statements
Safety Statements  24/25
RIDADR  3077
HS Code  29335990

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Chemical Properties,Uses,Production

Description

Alogliptin is a dipeptidyl-peptidase IV (DPP-4) inhibitor that was approved in Japan in 2010 for treatment of type 2 diabetes, a disease in which insulin resistance and β-cell dysfunction lead to hyperglycemia. As islet function is lost, the severity of insulin resistance increases. The introduction of DPP-4 inhibitors has brought a novel class of insulinotropic agents for the treatment options available to type 2 diabetic patients. The therapeutic potential of glucagon-like peptide 1 (GLP-1), an incretin peptide, for the treatment of type 2 diabetes was realized in the 1990s. The insulinotropic effects of GLP-1 depend closely on glucose concentrations providing the possibility of glucose normalization without the risk of hypoglycemia. GLP-1 has other non-insulinotropic physiological actions that are advantageous. It suppresses glucagon secretion from a cells and slows gastric emptying, which contributes to satiety and to a slower passage and reabsorption of carbohydrates. GLP-1 also contributes to satiety via a central mechanism as a neurotransmitter with effects on the hypothalamus.

Chemical Properties

White Solid

Originator

Syrrx Inc. (now Takeda San Diego) (Japan)

Uses

Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.

Definition

ChEBI: A piperidine that is 3-methyl-2,4-dioxo-3,4-dihydropyrimidine carrying additional 2-cyanobenzyl and 3-aminopiperidin-1-yl groups at positions 1 and 2 respectively (the R-enantiomer). Used in the form of its benzoate salt for treatment of t pe 2 diabetes.

brand name

Nesina

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Preparation Products And Raw materials

Raw materials

Preparation Products


ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Suppliers

Global( 178)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21031 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29960 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Shanghai Yingrui Biopharma Co.,Ltd
+86-21-33585366
+86-21-34979012 export01@shyrchem.com CHINA 1321 58

View Lastest Price from ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-26 Alogliptin
850649-61-5
US $1070.00 / KG 1KG 99% 600KG Shandong Luning Pharmaceutical Co., Ltd.
2021-07-13 Alogliptin
850649-61-5
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 Alogliptin
850649-61-5
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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