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Iguratimod

Iguratimod
Iguratimod structure
CAS No.
123663-49-0
Chemical Name:
Iguratimod
Synonyms
T 614;CS-1961;IGURATIMOD;Iguratimod >iguratimod( R&D);IguratiMod (T 614);Iguratimod USP/EP/BP;N-[7-methanesulfonamido-4-oxo-6-(phenoxy)chromen-3-yl]formamide;N-(3-Formamido-4-oxo-6-phenoxy-4H-chromen-7-yl)methanesulfonamide;N-(7-(MethylsulfonaMido)-4-oxo-6-phenoxy-4H-chroMen-3-yl)forMaMide
CBNumber:
CB91011295
Molecular Formula:
C17H14N2O6S
Formula Weight:
374.37
MOL File:
123663-49-0.mol

Iguratimod Properties

Melting point:
238.0 to 242.0 °C
Boiling point:
580.6±60.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
pka
5.58±0.20(Predicted)
FDA UNII
4IHY34Y2NV

Iguratimod price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical I0945 Iguratimod >98.0%(HPLC)(T) 123663-49-0 25mg $50 2021-12-16 Buy
TCI Chemical I0945 Iguratimod >98.0%(HPLC)(T) 123663-49-0 250mg $289 2021-12-16 Buy
TRC I265100 Iguratimod 123663-49-0 50mg $95 2021-12-16 Buy
TRC I265100 Iguratimod 123663-49-0 100mg $175 2021-12-16 Buy
Chem-Impex 37972 Iguratimod,98%(HPLC) 98%(HPLC) 123663-49-0 25MG $47.04 2021-12-16 Buy

Iguratimod Chemical Properties,Uses,Production

Description

In August 2011, China’s State FDA approved Simcere Pharmaceutical Group’s new drug application for iguratimod (T-614), a disease modifying anti-rheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Preclinical in vivo studies indicated that iguratimod was effective in an established adjuvant-induced arthritis model (ED40=3.6 mg/kg) in rats and also efficacious in a type II collagen-induced arthritis model in DBA/1J mice at 30 mg and 100 mg/kg.

Originator

Toyama (Japan)

Uses

Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis.

brand name

Iremod

Clinical Use

Iguratimod, which was discovered by Toyama Pharmaceuticals and jointly co-developed with Eisai in Japan, was approved by the PMDA (Pharmaceuticals and Medical Devices Agency) of Japan on June 29, 2012 for the treatment of rheumatoid arthritis. This drug was also independently developed by Simcere Pharmaceutical Group and is marked as Iremod® in China. The drug exhibited inhibitory effects on granuloma inflammation, and was shown to be efficacious for the prevention of joint destruction in adjuvant arthritis.

Chemical Synthesis

Several synthesis of iguratimod have been published, the most likely scale synthesis, which does not require chromatographic purification, is described in the scheme.The synthesis began with commercially available 3-nitro-4-chloro anisole (78) which was reacted with potassium phenoxide (generated from phenol and potassium t-butoxide at 110 oC) to provide the corresponding nitrophenyl ether which was subsequently reduced and sulfonylated to furnish sulfonamide 79. Next, this diphenyl ether was subjected to a Friedel-Crafts reaction with aminoacetonitrile hydrochloride which gave rise to aminomethylacetophenone 80 in 90% yield. This aminoketone was then formylated with formic trimethylacetic anhydride 81 at room temperature to afford formamide 82 in 91% yield, and this material was immediately subjected to O-demethylation conditions with aluminum trichloride and sodium iodide in acetonitrile to give the phenol 83 in 95% yield. Finally, treatment of the aminomethyl acetophenone phenol 83 with N,N-dimethylformamide dimethylacetal in DMF at low temperatures furnished iguratimod (XII) in 87% yield.

Iguratimod Preparation Products And Raw materials

Raw materials

Preparation Products


Iguratimod Suppliers

Global( 164)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com China 2008 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5942 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58

View Lastest Price from Iguratimod manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-19 Iguratimod
123663-49-0
US $0.00 / KG 10g 99%min 10kg WUHAN FORTUNA CHEMICAL CO., LTD
2021-11-02 Iguratimod
123663-49-0
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
2021-07-20 Iguratimod
123663-49-0
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd

123663-49-0(Iguratimod)Related Search:


  • IGURATIMOD
  • iguratimod( R&D)
  • T 614
  • N-[7-methanesulfonamido-4-oxo-6-(phenoxy)chromen-3-yl]formamide
  • 3-(Formylamino)-7-(methylsulfonylamino)-6-phenoxy-4H-1-benzopyran-4-one
  • N-[3-(Formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]methanesulfonamide
  • IguratiMod (T 614)
  • N-(7-(MethylsulfonaMido)-4-oxo-6-phenoxy-4H-chroMen-3-yl)forMaMide
  • CS-1961
  • N-[7-(methanesulfonamido)-4-oxo-6-phenoxy-1-benzopyran-3-yl]formamide
  • Iguratimod >
  • Methanesulfonamide, N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]-
  • N-(3-Formamido-4-oxo-6-phenoxy-4H-chromen-7-yl)methanesulfonamide
  • N-[7-(Methanesulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl]formamide
  • Iguratimod USP/EP/BP
  • 123663-49-0
  • Pharmaceutical intermediate
  • Pharmaceuticals
  • API
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