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3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)-

3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- structure

CAS No.: 1269826-44-9

Chemical Name:: 3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)-

Synonyms: OSBPL7-IN-1;ABCA1 inducer compound G;OSBPL7,orally active,ABCA1,OSBPL7 IN 1,Inhibitor,OSBPL-7-IN-1,OSBPL7IN1,inhibit;3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)-

CBNumber:: CB910228978

Molecular Formula:: C20H19Cl2F3N2O3

Molecular Weight:: 463.28

MDL Number:

MOL File:: 1269826-44-9.mol

Last updated:2023-09-04 15:50:00

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3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- Properties

Boiling point	540.9±50.0 °C(Predicted)
Density	1.46±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	5.98±0.40(Predicted)

3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- Chemical Properties,Uses,Production

Biological Activity

OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1]. OSBPL7-IN-1 (compound G or Cpd G; 1-10 μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1]. OSBPL7-IN-1 (100 mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria and prevents renal function decline in mouse models of proteinuric kidney disease[1].

References

[1]. Matthew B Wright, et al. Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nat Commun. 2021 Aug 2;12(1):4662.

3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- Preparation Products And Raw materials

Raw materials

Preparation Products

3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- Suppliers

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TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Chaolan Chemical Technology Center	58
Shanghai SuperLan Chemcial Technique Centre	58
TargetMol Chemicals Inc.	58

3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- Spectrum

3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)-(1269826-44-9)¹HNMR

3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- OSBPL7-IN-1 OSBPL7,orally active,ABCA1,OSBPL7 IN 1,Inhibitor,OSBPL-7-IN-1,OSBPL7IN1,inhibit ABCA1 inducer compound G 1269826-44-9 C20H19Cl2F3N2O3