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Hexamethyldisilazane

Reaction
Hexamethyldisilazane
Hexamethyldisilazane structure
CAS No.
999-97-3
Chemical Name:
Hexamethyldisilazane
Synonyms
HMDS;HMDZ;sz6079;tsl8802;HMDS, 30ML;HMDS >=99%;SILAZANE HMN;((CH3)3Si)2NH;DYNASYLAN HMDS;MM capping agent
CBNumber:
CB9105784
Molecular Formula:
C6H19NSi2
Formula Weight:
161.39
MOL File:
999-97-3.mol

Hexamethyldisilazane Properties

Melting point:
-78 °C
Boiling point:
125 °C (lit.)
Density 
0.774 g/mL at 25 °C(lit.)
vapor density 
4.6 (vs air)
vapor pressure 
20 hPa (20 °C)
refractive index 
n20/D 1.407(lit.)
Flash point:
57.2 °F
storage temp. 
Store below +30°C.
solubility 
Miscible with acetone, benzene, ethyl ether, heptane and perchloroethylene.
pka
30(at 25℃)
form 
Liquid
color 
Colorless
Specific Gravity
0.774
Odor
Ammonia odour
PH Range
8.5
Evaporation Rate
< 1
explosive limit
0.8-25.9%(V)
Water Solubility 
REACTS
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
7: reacts slowly with moisture/water
Merck 
14,4689
BRN 
635752
InChIKey
FFUAGWLWBBFQJT-UHFFFAOYSA-N
CAS DataBase Reference
999-97-3(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
H36C68P1BH
NIST Chemistry Reference
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-(999-97-3)
EPA Substance Registry System
Hexamethyldisilazane (999-97-3)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS06,GHS05
Signal word  Danger
Hazard statements  H302-H314-H318-H331-H225-H302+H332-H311-H412
Precautionary statements  P210-P261-P273-P280-P302+P352+P312-P304+P340+P312-P260h-P303+P361+P353-P305+P351+P338-P405-P501a
Hazard Codes  F,C,Xn
Risk Statements  11-20/21/22-34-52/53
Safety Statements  16-26-36/37/39-45-61
RIDADR  UN 3286 3/PG 2
WGK Germany  2
RTECS  JM9230000
21
Autoignition Temperature 325 °C
Hazard Note  Flammable
TSCA  Yes
HS Code  2931 90 00
HazardClass  3
PackingGroup  II
Toxicity LDLO i.p. in mice: 650 mg/kg (Petrarch Systems Inc. Product Information Sheets)
NFPA 704
3
1 1

Hexamethyldisilazane price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.04324 1,1,1,3,3,3-Hexamethyldisilazane for synthesis 999-97-3 50 mL $29.23 2021-03-22 Buy
Sigma-Aldrich 379212 Hexamethyldisilazane ReagentPlus , 99.9% 999-97-3 25ml $41.3 2021-03-22 Buy
Sigma-Aldrich 33350-U HMDS, Derivatization Grade 999-97-3 u $55 2020-08-18 Buy
Sigma-Aldrich 8.04324 1,1,1,3,3,3-Hexamethyldisilazane for synthesis 999-97-3 250 mL $82.51 2021-03-22 Buy
Sigma-Aldrich 8.04324 1,1,1,3,3,3-Hexamethyldisilazane for synthesis 999-97-3 1 L $202.57 2021-03-22 Buy

Hexamethyldisilazane Chemical Properties,Uses,Production

Reaction

Hexamethyldisilazane(HMDS) is an extremely versatile and strong silylating agent. It is primarily used for the protection of sensitive functional groups during chemical synthesis.One of the advantages of Hexamethyldisilazane over chlorosilanes is that no base is needed as a hydrochloric acid acceptor. It produces ammonia which escapes easily from the reaction mixture during silylation.

Description

Hexamethyldisilazane is a bulk organo silicon compound, being a quite useful silanizing agent. It is a reagent for the preparation of trimethylsilyl derivatives. It can be used for silanizing the surface of silicon water, cellulose. It can also be used to dehydrate cells of biomaterials for scanning electron microscopy (SEM). The hexamethyldisilazane coatings on various nanoparticles make them be resistant to water contamination and flocculation during synthesis. It can also be used as a modifier to control the shape, formation of agglomerates surface area and pore size of silica particles. Moreover, it is an adhesion promoter for photoresist in photolithography, and is also useful in the pyrolysis-gas chromatography-mass spectrometry to enhance the detectability of compounds with polar functional groups.

Chemical Properties

Colorless liquid

Physical properties

bp 125 °C; d 0.765 g cm?3.

Uses

Deactivation of chromatographic support materials. In electronic industry as an adhesion promoter for photoresists on silicon.

Uses

Hexamethyldisilazane mainly used as methyl silane alkylation (such as amikacin, penicillin, cephalosporins and kinds of penicillin derivatives), hydroxyl protectants of antibiotics. It is used as surface treatment agent of diatomite, white carbon black, titanium and blond additives of photoresist in the semiconductor industry. It is used as treatment agent of tearing strength resistance. It is used as a solvent in organic synthesis and organometallic chemistry. It is used as an adhesion promoter for photoresist in photolithography. it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical point drying during sample preparation in electron microscopy. It is added to analyte to get silylated diagnostic products during pyrolysis in gas chromatography- mass spectrometry.

Uses

A reagent for the preparation of trimethylsilyl derivatives.

Definition

ChEBI: An N-silyl compound obtained from ammonia by replacement of two of the hydrogens with trimethylsilyl groups. Hexamethyldisilazane is a derivatisation agent used in gas chromatography mass spectrometry applications.

General Description

A liquid. Boiling point of 260°F. Flash point 77°F. May be toxic by ingestion. Irritates skin and eyes. Vapors are heavier than air. May emit highly toxic nitrogen oxide fumes when heated to decomposition. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Moisture sensitive.

Reactivity Profile

Hexamethyldisilazane reacts with many carbonyl containing organic compounds to generate gaseous ammonia. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Flammable, moderate fire risk.

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Purification Methods

A possible impurity is Me3SiCl. Wash it well with pet ether and fractionate it through a vacuum jacketed column packed with Helipac using a reflux ratio of 10:1. [Langer et al. J Org Chem 23 50 1958, Beilstein 4 IV 4014.]

References

Deng, Xiang. "Hexamethyldisilazane." Synlett 2011.06(2011):881-882. Chiavari, G, D. Fabbri, and S. Prati. "Gas chromatographic-mass spectrometric analysis of products arising from pyrolysis of amino acids in the presence of hexamethyldisilazane." Journal of Chromatography A922.1–2(2001):235-241.
Nation, J. L. "A new method using hexamethyldisilazane for preparation of soft insect tissues for scanning electron microscopy." Stain Technology 58.6(1983):347-51.
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Hexamethyldisilazane Preparation Products And Raw materials

Raw materials

Preparation Products


Hexamethyldisilazane Suppliers

Global( 518)Suppliers
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View Lastest Price from Hexamethyldisilazane manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-03 Hexamethyldisilazane
999-97-3
US $0.00 / Kg/Drum 1KG 99% 2000mt/year Jinan Finer Chemical Co., Ltd
2021-12-01 Hexamethyldisilazane
999-97-3
US $1.70 / Kg/Drum 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-11-30 Hexamethyldisilazane
999-97-3
US $20.00 / KG 1T 99% 1000T Baoji Guokang Bio-Technology Co., Ltd.

Hexamethyldisilazane Spectrum


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