PB28dihydrochloride
- CAS No.
- 172906-90-0
- Chemical Name:
- PB28dihydrochloride
- Synonyms
- PB-28;PB28 dihydrochloride >=98% (HPLC), solid;Piperazine,1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]-;1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazinedihydrochloride
- CBNumber:
- CB91074562
- Molecular Formula:
- C24H38N2O
- Molecular Weight:
- 370.57
- MDL Number:
- MFCD06798349
- MOL File:
- 172906-90-0.mol
| Boiling point | 501.4±50.0 °C(Predicted) |
|---|---|
| Density | 1.032±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at +4°C |
| solubility | H2O: ~10mg/mL at 60°C |
| pka | 8.32±0.70(Predicted) |
| form | solid |
| color | white |
| FDA UNII | XTX7Z22467 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
PB28dihydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P9246 | PB28 dihydrochloride ≥98% (HPLC), solid | 172906-90-0 | 5mg | $132 | 2024-03-01 | Buy |
| TRC | P215100 | PB28 | 172906-90-0 | 2.5mg | $215 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004726 | PB-28 95.00% | 172906-90-0 | 10MG | $665.81 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004726 | PB-28 95.00% | 172906-90-0 | 50MG | $1073.29 | 2021-12-16 | Buy |
PB28dihydrochloride Chemical Properties,Uses,Production
Uses
PB 28 is a selective σ2 receptor agonist. It is also an antitumor and cytotoxic agent.
Definition
ChEBI: PB28 is a member of the class of tetralins that is tetralin that is substituted by 3-(4-cyclohexylpiperazin-1-yl)propyl and methoxy groups at positions 1 and 5, respectively. It is a sigma 2 (sigma2) receptor agonist (Ki = 0.68 nM) and exhibits antineoplastic and anti SARS-CoV-2 activities. It has a role as an anticoronaviral agent, an antineoplastic agent, an apoptosis inducer and a sigma-2 receptor agonist. It is an aromatic ether, a member of piperazines and a member of tetralins.
Biological Activity
High affinity σ 2 receptor agonist (K i values are 0.8 and 15.2 nM for σ 2 and σ 1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC 50 values are 2.62 and 3.96 μ M respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
PB28dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
PB28dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2210 | 55 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 | psaitong@jm-bio.com | China | 29834 | 58 |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | 2881924050@qq.com | China | 9991 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |