ChemicalBook >> CAS DataBase List >>L-5-Hydroxytryptophan

L-5-Hydroxytryptophan

CAS No.
4350-09-8
Chemical Name:
L-5-Hydroxytryptophan
Synonyms
5-HTP;L-HTP;L-5-HTP;quietim;Levothym;pretonine;HPLC>=98%;OXITRIPTAN;L-oxitriptan;H-TRP(5-OH)-OH
CBNumber:
CB9110025
Molecular Formula:
C11H12N2O3
Formula Weight:
220.22
MOL File:
4350-09-8.mol
MSDS File:
SDS

L-5-Hydroxytryptophan Properties

Melting point
270 °C (dec.) (lit.)
alpha
-32.5 º (c=1,H2O on dry basis)
Boiling point
361.16°C (rough estimate)
Density
0.902 g/mL at 25 °C (lit.)
refractive index
n20/D 1.4850(lit.)
Flash point
175 °F
storage temp.
2-8°C
solubility
H2O: 10 mg/mL
pka
2.22±0.10(Predicted)
form
solid
color
white
optical activity
[α]22/D 30°, c = 1 in H2O
Water Solubility
Slightly soluble
Merck
14,4847
BRN
88200
CAS DataBase Reference
4350-09-8(CAS DataBase Reference)
FDA UNII
C1LJO185Q9
ATC code
N06AX01
NCI Drug Dictionary
oxitriptan
EPA Substance Registry System
L-5-Hydroxytryptophan (4350-09-8)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06,GHS07
Signal word  Danger
Hazard statements  H301-H315-H319-H335-H302
Precautionary statements  P264-P270-P301+P312a-P330-P501a-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-65-20/21/22-20/21
Safety Statements  36-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  YN7110000
3-10
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29339990
NFPA 704
1
2 0

L-5-Hydroxytryptophan price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2597 5-Hydroxy-L-tryptophan Pharmaceutical Secondary Standard; Certified Reference Material 4350-09-8 100MG $233 2022-05-15 Buy
Sigma-Aldrich PHL80477 5-Hydroxy-L-tryptophan phyproof? Reference Substance 4350-09-8 50MG $231 2022-05-15 Buy
Sigma-Aldrich 399698 5-Hydroxy-L-tryptophan - CAS 895096 - Calbiochem Serotonin precursor. 4350-09-8 25G $466 2022-05-15 Buy
Sigma-Aldrich 1329913 5-Hydroxy-L-tryptophan United States Pharmacopeia (USP) Reference Standard 4350-09-8 100mg $400 2022-05-15 Buy
Sigma-Aldrich 107751 5-Hydroxy-L-tryptophan 98% (calc. on dried substance) 4350-09-8 1g $39.4 2022-05-15 Buy
Product number Packaging Price Buy
PHR2597 100MG $233 Buy
PHL80477 50MG $231 Buy
399698 25G $466 Buy
1329913 100mg $400 Buy
107751 1g $39.4 Buy

L-5-Hydroxytryptophan Chemical Properties,Uses,Production

Chemical Properties

white to pale grey powder

Uses

A labelled metabolite of Tryptophan

Uses

5-Hydroxy-L-tryptophan has been used:
  • to inject experimental mice for serotonin detection
  • as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices
  • as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis

Uses

5-Hydroxy-L-Tryptophan is a hydroxylated metabolite of L-Tryptophan

General Description

Colorless to pale pink crystals.

Air & Water Reactions

L-5-Hydroxytryptophan is sensitive to air. Slightly water soluble .

Reactivity Profile

L-5-Hydroxytryptophan reacts with bases. .

Fire Hazard

Flash point data for L-5-Hydroxytryptophan are not available, however, L-5-Hydroxytryptophan is probably combustible.

Biochem/physiol Actions

Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache.

Purification Methods

Likely impurities are 5-hydroxy-D-tryptophan and 5-benzyloxytryptophan. Crystallise 5-hydroxy-L-tryptophan under nitrogen from water by adding EtOH. Store it under nitrogen. Also dissolve it in the minimum volume of hot H2O (~0.7g in 4mL) under nitrogen (charcoal) and allowed it to crystallise at 5o. The picrolonate crystallises from H2O with m 184-186o(dec). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2732-2737 1961, Morris & Armstrong J Org Chem 22 306 1957, Beilstein 22/14 V 278.]

L-5-Hydroxytryptophan Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 375)Suppliers
Supplier Tel Email Country ProdList Advantage
Aktin Chemicals, Inc.
028-85159085 info@aktinchem.com CHINA 1026 58
Gihi Chemicals Co., Limited
+86-571-86217390 +86-18058761490 info@gihichem.com China 954 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 19994 60
Henan DaKen Chemical CO.,LTD.
371-66670886 info@dakenchem.com China 15400 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 info@tianfuchem.com China 22022 55
ATK CHEMICAL COMPANY LIMITED
21-51619050 ivan@atkchemical.com China 26810 60
career henan chemical co
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HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
+86-86-18903210395 +86-19930599843 cindy@hbyingong.com China 741 58
Jinan Jianfeng Chemical Co., Ltd
+8615562555968 info@pharmachemm.com China 215 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254 linda@hubeijusheng.com CHINA 28229 58

View Lastest Price from L-5-Hydroxytryptophan manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-05-12 L-5-Hydroxytryptophan
4350-09-8
US $90.00 / kg 1kg 99% 80MT Hebei baicao biology science and technology co., ltd
2022-04-05 cis-2,6-Dimethylmorpholine
4350-09-8
US $30.00 / KG 1KG 99% 20 Tons Wuhan wingroup Pharmaceutical Co., Ltd
2022-02-25 L-5-Hydroxytryptophan
4350-09-8
US $1.00 / ASSAYS 1g 99.99%+ 20T Jinan Jianfeng Chemical Co., Ltd
5-hydroxy-l-tryptopha pretonine L-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID L-5-HYDROXYTRYPTOPHAN HYDRATE L-5-HYDROXYTRYPTOPHAN L-5-HTP 2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPIONIC ACID (-)-5-HYDROXY-L-TRYPTOPHAN 5-HYDROXY-L-TRYPTOPHAN 5-HYDROXY-L-TRP-OH 5-HYDROXY-TRP-OH 5-HTP C5-HYDROXY-L-TRYPTOPHAN H-5-HYDROXY-TRP-OH H-TRP(5-OH)-OH (S)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)-PROPIONIC ACID (2S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid Levothym L-5-Hydroxytryptophan,99% L-5-Hydroxytryptopha (S)-5-Hydroxytryptophan 5-Hydroxytryptophan(5-HTP,Oxitriptan) (S)-2-AMino-3-(5-hydroxy-1H-indol-3-yl)-propionic acid, C5-Hydroxy-L-tryptophan, 5-HTP, Oxitriptan 5-Hydroxy-L-tryptophan-d 3 L-5-Hydroxytryptophan, 99% 1GR L-5-Hydroxytryptophan, 99% 5GR L-5-HTP, L-2-Amino-3-(5-hydroxyindolyl)propionic acid 5-Hydroxy-L-tryphophane (S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid 5-Hydroxy-L-tryptophan 98% (calc. on dried substance) 5-Hydroxy-L-tryptophan(5-HTP) 5-Hydroxy-L-tryptophan99% L-Trp(5-OH)-OH OXITRIPTAN 5-Hydroxy-L-tryptophan, Free Acid Griffonia seed L-Tryptophan, 5-hydroxy- l-2-amino-3-[3-(5-hydroxyindole)]propionic acid 5-HYDROXY-1-TRYTOPHAN 5-Hydroxyl-L-tryptophan. quietim 5-HYDROXY-L-TRYPTOPHAN 99,0 % min 5-Hydroxy-L-tryptophane H-L-Trp(5-OH)-OH 5-HTP Griffonia Seed L-2-Amino-3-(5-hydroxyindolyl)propionic acid, L-5-HTP 5-HYDROXY-L-TRYPTOPHAN 99% 5-HTP HPLC L-2-Amino-3-(5-hydroxyindolyl)propionic acid L-5-HTP 5-HTP 5-Hydroxy-L-tryptophan, Dihydrate L-HTP Tryptophan Impurity 9(Tryptophan EP Impurity D) L-5-Hydroxytryptophan (Synonyms: L-5-HTP Ghana seed extract L-5-Hydroxytryptophan (L-5-HTP L-5-Hydroxytryptophan(Tryptophan EP Impurity D) HPLC>=98% 5-Hydroxy-L-tryptophan> (S)-2-Amino-3-(5-hydroxy-1H-indol-3