ChemicalBook >> CAS DataBase List >>L-5-Hydroxytryptophan
L-5-Hydroxytryptophan
- CAS No.
- 4350-09-8
- Chemical Name:
- L-5-Hydroxytryptophan
- Synonyms
- 5-HTP;5-HYDROXY-L-TRYPTOPHAN;OXITRIPTAN;(S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid;L-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID;L-5-HTP;Griffonia seed;5-hydroxy-l-tryptopha;5-Hydroxy-L-tryptophane;L-HTP
- CBNumber:
- CB9110025
- Molecular Formula:
- C11H12N2O3
- Molecular Weight:
- 220.22
- MDL Number:
- MFCD00064341
- MOL File:
- 4350-09-8.mol
- MSDS File:
- SDS
Modify Date:2023-05-25
| Melting point | 270 °C (dec.) (lit.) |
|---|---|
| alpha | -32.5 º (c=1,H2O on dry basis) |
| Boiling point | 361.16°C (rough estimate) |
| Density | 0.902 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 175 °F |
| storage temp. | 2-8°C |
| solubility | H2O: 10 mg/mL |
| pka | 2.22±0.10(Predicted) |
| form | solid |
| color | white |
| optical activity | [α]22/D 30°, c = 1 in H2O |
| Water Solubility | Slightly soluble |
| Merck | 14,4847 |
| BRN | 88200 |
| LogP | -0.140 (est) |
| CAS DataBase Reference | 4350-09-8(CAS DataBase Reference) |
| FDA UNII | C1LJO185Q9 |
| NCI Drug Dictionary | oxitriptan |
| ATC code | N06AX01 |
| EPA Substance Registry System | L-5-Hydroxytryptophan (4350-09-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P330+P331+P310 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38-65-20/21/22-20/21 | |||||||||
| Safety Statements | 36-26 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YN7110000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339990 | |||||||||
| NFPA 704 |
|
L-5-Hydroxytryptophan price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL80477 | 5-Hydroxy-L-tryptophan phyproof? Reference Substance | 4350-09-8 | 50MG | $250 | 2023-01-07 | Buy |
| Sigma-Aldrich | 107751 | 5-Hydroxy-L-tryptophan 98% (calc. on dried substance) | 4350-09-8 | 1g | $42.7 | 2023-01-07 | Buy |
| Sigma-Aldrich | PHR2597 | 5-Hydroxy-L-tryptophan Pharmaceutical Secondary Standard; Certified Reference Material | 4350-09-8 | 100MG | $233 | 2022-05-15 | Buy |
| Sigma-Aldrich | 399698 | 5-Hydroxy-L-tryptophan - CAS 895096 - Calbiochem Serotonin precursor. | 4350-09-8 | 25G | $466 | 2022-05-15 | Buy |
| Sigma-Aldrich | 1329913 | 5-Hydroxy-L-tryptophan United States Pharmacopeia (USP) Reference Standard | 4350-09-8 | 100mg | $400 | 2022-05-15 | Buy |
L-5-Hydroxytryptophan Chemical Properties,Uses,Production
Chemical Properties
white to pale grey powder
Uses
5-Hydroxy-L-Tryptophan is a hydroxylated metabolite of L-Tryptophan
Uses
A labelled metabolite of Tryptophan
Uses
5-Hydroxy-L-tryptophan has been used:
- to inject experimental mice for serotonin detection
- as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices
- as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis
Definition
ChEBI: 5-hydroxy-L-tryptophan is the L-enantiomer of 5-hydroxytryptophan. It has a role as a human metabolite, a plant metabolite and a mouse metabolite. It is a 5-hydroxytryptophan, a hydroxy-L-tryptophan and a non-proteinogenic L-alpha-amino acid. It is an enantiomer of a 5-hydroxy-D-tryptophan. It is a tautomer of a 5-hydroxy-L-tryptophan zwitterion.
General Description
Colorless to pale pink crystals.
Air & Water Reactions
L-5-Hydroxytryptophan is sensitive to air. Slightly water soluble .
Reactivity Profile
L-5-Hydroxytryptophan reacts with bases. .
Fire Hazard
Flash point data for L-5-Hydroxytryptophan are not available, however, L-5-Hydroxytryptophan is probably combustible.
Biochem/physiol Actions
Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache.
Purification Methods
Likely impurities are 5-hydroxy-D-tryptophan and 5-benzyloxytryptophan. Crystallise 5-hydroxy-L-tryptophan under nitrogen from water by adding EtOH. Store it under nitrogen. Also dissolve it in the minimum volume of hot H2O (~0.7g in 4mL) under nitrogen (charcoal) and allowed it to crystallise at 5o. The picrolonate crystallises from H2O with m 184-186o(dec). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2732-2737 1961, Morris & Armstrong J Org Chem 22 306 1957, Beilstein 22/14 V 278.]
L-5-Hydroxytryptophan Preparation Products And Raw materials
Global( 439)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Gihi Chemicals Co., Limited | +86-0571-86217390 +8618058761490 | info@gihichem.com | China | 998 | 58 |
| Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +undefined13970866816 | info@zybiopharma.com | China | 246 | 58 |
| XI AN SGONEK BIOLOGICAL TECHNOLOGY CO., LTD | 15202951039 | jason@sgonekbio.com | China | 268 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29810 | 60 |
| Henan DaKen Chemical CO.,LTD. | +86-371-66670886 | info@dakenchem.com | China | 18267 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21975 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 31813 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29922 | 58 |
| HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD | +86-19933070948 +86-19930599843 | claire@hbyingong.com | China | 963 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | +8615562555968 | info@pharmachemm.com | China | 233 | 58 |
View Lastest Price from L-5-Hydroxytryptophan manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-05-30 | L-5-Hydroxytryptophan
4350-09-8
|
US $1.00 / ASSAYS | 1g | 99.99%+ | 20T | Jinan Jianfeng Chemical Co., Ltd | |
 |
2023-05-19 | L-5-Hydroxytryptophan
4350-09-8
|
US $150.00 / ASSAYS | 10g | >99% | 500kg/month | HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD | |
 |
2023-02-24 | 5-Hydroxy-L-tryptophan
4350-09-8
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- L-5-Hydroxytryptophan
4350-09-8
- US $1.00 / ASSAYS
- 99.99%+
- Jinan Jianfeng Chemical Co., Ltd
-
- L-5-Hydroxytryptophan
4350-09-8
- US $150.00 / ASSAYS
- >99%
- HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
-
- 5-Hydroxy-L-tryptophan
4350-09-8
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
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