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Dichlorophen

Description Sources
Dichlorophen
Dichlorophen structure
CAS No.
97-23-4
Chemical Name:
Dichlorophen
Synonyms
G 4;DDDM;Fungo;Gefir;Trivex;G-4(R);Hyosan;Korium;Halenol;Palacel
CBNumber:
CB9111491
Molecular Formula:
C13H10Cl2O2
Formula Weight:
269.12
MOL File:
97-23-4.mol

Dichlorophen Properties

Melting point:
168-172 °C (lit.)
Boiling point:
418.7±40.0 °C(Predicted)
Density 
1.3239 (estimate)
vapor pressure 
1.3 x 10-5 Pa (25 °C)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in methanol, ether
form 
neat
pka
pK1:7.6;pK2:11.5 (25°C)
Water Solubility 
<0.1 g/100 mL at 22 ºC
Merck 
14,3071
BRN 
1884514
Stability:
Stable. Incompatible with strong bases, strong oxidizing agents.
Indirect Additives used in Food Contact Substances
2,2'-DIHYDROXY-5,5'-DICHLOROPHENYLMETHANE (DICHLOROPHENE)
CAS DataBase Reference
97-23-4(CAS DataBase Reference)
FDA 21 CFR
176.170; 310.545
EWG's Food Scores
6-9
FDA UNII
T1J0JOU64O
Proposition 65 List
Dichlorophene
NIST Chemistry Reference
Phenol], 2,2'-methylenebis[4-chloro-(97-23-4)
EPA Substance Registry System
Dichlorophene (97-23-4)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H319-H410-H400
Precautionary statements  P264-P280i-P301+P312a-P337+P313-P501a-P301+P312+P330-P305+P351+P338
Hazard Codes  Xn,N
Risk Statements  22-36-50/53
Safety Statements  26-60-61
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS  SM0175000
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29081990
Toxicity LD50 in adult male, female rats (mg/kg): 1506, 1683 orally (Gaines, Linder)

Dichlorophen price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 35992 Dichlorophene PESTANAL 97-23-4 250mg $21.4 2021-03-22 Buy
Sigma-Aldrich 133221 Bis(5-chloro-2-hydroxyphenyl)methane 95% 97-23-4 50g $75.8 2021-03-22 Buy
TCI Chemical M0213 2,2'-Methylenebis(4-chlorophenol) 97-23-4 25g $37 2021-03-22 Buy
TCI Chemical M0213 2,2'-Methylenebis(4-chlorophenol) 97-23-4 500g $128 2021-03-22 Buy
Alfa Aesar A12640 2,2'-Methylenebis(4-chlorophenol), 95% 97-23-4 100g $54.8 2021-03-22 Buy

Dichlorophen Chemical Properties,Uses,Production

Description

Dichlorophen is a nontoxic laxative vermicide of chlorinated phenol compound. It is an anticestodal agent, fungicide, germicide, anti-protozoan and antimicrobial agent. Its efficacy is restricted to Taenia spp, with poor to no activity against Echinococcus spp and Dipylidium caninum. Against these and other species, it may act against the strobilus, leaving the scolex to generate new proglottids. Its mechanism of action is thought to induce the uncoupling of oxidative phosphorylation. Therefore, it can be included as an ingredient in antimicrobial soaps and shampoos. It can be used in combination with toluene for the removal of parasites such as ascarids, hookworms, and tapeworms from dogs and cats. Dichlorophene can be used as a growth regulator in containerized seedlings of pine and spruce to regulate plant growth.

Sources

https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/dichlorophen
https://en.wikipedia.org/wiki/Dichlorophen
https://pubchem.ncbi.nlm.nih.gov/compound/Dichlorophen#section=Top
https://www.tabletwise.com/medicine/dichlorophene/uses-benefits-working
Andersson, B. "Analysis of plant growth regulating substances [incl. dichlorophene]." Annals of Applied Biology 43.2(1982):342-354.

Chemical Properties

white or off-white powder

Originator

Dichlorophen,Aquapharm

Uses

Dichlorophen exhibits algicidal, bactericidal and fungicidal activities. It is a contact fungicide used to control dollar spots and rots in turf. It is also an anthelminthic used for the treatment of various tapeworms in human and domestic animals.

Uses

anthelmintic

Uses

Agricultural fungicide; antimicrobial; germicide in soaps, shampoos, etc.

Manufacturing Process

2.520 g of sulfuric acid (93%) is stirred and cooled to 0°C. A solution of 552 g of p-chlorophenol in 305 g of methyl alcohol is run into the acid, the temperature being kept below 10°C. The mixture is cooled to -5°C and a solution of 170 g of aqueous formaldehyde solution (37% CH2O in water) in 332 g of methyl alcohol is introduced at a more or less uniform rate over a period of 4 hours. The temperature of the reaction mixture is not allowed to rise above 0°C. After all of the formaldehyde-containing solution has been added, the batch is stirred for 3 hours longer at a temperature of -5°-0°C.
Enough ice is then added to the contents of the reaction chamber in order to reduce the sulfuric acid concentration to 70%. 2,2'-Dihydroxy-5,5'-dichlorodiphenyl methane is extracted from the resulting mixture with a mixture of 1.069 g of isopropyl ether and 1.575 g of toluene. Ice is added until the acid concentration is about 30%. The acid layer is removed and the solvent layer is washed acid-free. Most of the isopropyl ether is removed by atmospheric distillation with a fractionating column, the temperature of the escaping vapors not being permitted to exceed 90°C. From the residue, about 280 g of pure 2,2'-dihydroxy-5,5'-dichloro-diphenyl methane, MP: 177°-178°C, crystallize. The product is filtered, washed with toluene and dried at about 100°C. By concentrating the mother liquor remaining after the foregoing crystallization and filtration, another 225 grams of substantially pure 2,2'- dihydroxy-5,5'-dichloro-diphenyl methane are obtained. This latter crop may be crystallized from toluene in order to convert it into 2,2'-dihydroxy-5,5'- dichlorodiphenyl methane of melting point of 177°-178°C.

Therapeutic Function

Antiseptic, Anthelmintic, Antifungal

General Description

White slightly cream or light pink-colored powder. Melting point 177°C. Slight phenolic odor and a saline phenolic taste. Moderately toxic. Used as a fungicide and bactericide.

Air & Water Reactions

Slowly oxidized in air. Insoluble in water.

Reactivity Profile

Dichlorophen is incompatible with strong oxidizing agents and strong bases . Weakly acidic.

Fire Hazard

Flash point data for Dichlorophen are not available; however, Dichlorophen is probably combustible.

Agricultural Uses

Fungicide, Herbicide, Bactericide, Veterinary medicine: Not currently registered in the U.S. Dichlorophene is a wide-spectrum, non-oxidizing biocide used against all types of algae and bacteria. Widely used to treat fungi, fleas and worm conditions in pet animals and livestock. See U.S. Food and Drug Administration 20 CFR 520.580 and 20 CFR 520.581

Trade name

ANTHIPHEN®; DIPHENTANE 70®; DICHLOROPHEN®; DICHLOROPHEN B®; DICHLOROPHENE 10®; DICHLORPHEN®; DIDROXANE®; DIPHENTHANE 70®; FUNGICIDE F®; FUNGICIDE GM®; FUNGICIDE M®; G 4®; GEFIR®; HYOSAN; KORIUM®; PLATH-LYSE®; PREVENTAL®; PREVENTOL®; PREVENTOL GD®; PREVENTOL GDC®; SUPER MOSSTOX®; TAENIATOL®; TENIATOL®; TENIATHANE®; TRIVEX®; VERMITHANA®; WESPURIL®

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion. A skin and severe eye irritant. Mutation data reported. Can cause cramps and diarrhea. Possibly similar to DDT. An FDA over-the counter drug. An anthelmintic. When heated to decomposition it emits toxic fumes of Cl-.

Metabolic pathway

Limited information is available to describe the degradation and metabolic fate of dichlorophen. A photodegradation study showed that dichlorophen undergoes hydroxydechlorination and dechlorination reactions as the major degradation pathways. Direct conjugation of one or both hydroxyl groups with sulfate and/or glucuronic acid was observed as the major metabolic pathway in the rat.

Purification Methods

Crystallise dichlorophen from toluene. [Beilstein 6 III 5406.]

Degradation

Dichlorophen (1) underwent hydroxydechlorination in acidic solution (pH 5.6) when irradiated under a xenon lamp (280 and 300 nm). 4-Chloro- 4'-hydroxy-2,2'-methylenediphenol(2) was the major product from reactions conducted in the absence of oxygen. A benzoquinone-like tautomer (3) was detected in oxygenated solution. A dechlorination product [4- chloro-2,2'-methylenediphenol(4)] was also observed as a minor product (Mansfield and Richard, 1996). These pathways are shown in Scheme 1.

Dichlorophen Preparation Products And Raw materials

Raw materials

Preparation Products


Dichlorophen Suppliers

Global( 163)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
City Chemical LLC
2039322489
203.937.8400 sales@citychemical.com United States 97 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5382 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17607 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58

View Lastest Price from Dichlorophen manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-26 Dichlorophen
97-23-4
US $8.70 / Kg/Bag 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-07-02 Dichlorophene
97-23-4
US $15.00 / g/Bag 10g/Bag 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06 Dichlorophen
97-23-4
US $1.00 / kg 1g 99% 100KG career henan chemical co

Dichlorophen Spectrum


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