Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>BUCLIZINE

BUCLIZINE

BUCLIZINE Structure
BUCLIZINE structure
CAS No.
82-95-1
Chemical Name:
BUCLIZINE
Synonyms
ah2526;AH 2526;Postafen;Bucladin;Buclifen;Buclozin;BUCLIZINE;Hitabutyzyne;Histabutyzine;Histabutizine
CBNumber:
CB9111794
Molecular Formula:
C28H33ClN2
Molecular Weight:
433.03
MDL Number:
MFCD00242701
MOL File:
82-95-1.mol
Last updated:2024-03-19 15:37:51
Request For Quotation

BUCLIZINE Properties

Boiling point bp0.001 217-220°
Density 0.9970 (rough estimate)
refractive index 1.5940 (estimate)
pka 6.84±0.10(Predicted)
EWG's Food Scores 1
FDA UNII 0C94V6X681
ATC code R06AE01,R06AE51

BUCLIZINE price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 443556 Buclizine 82-95-1 2.5mg $602 2021-12-16 Buy
Biosynth Carbosynth FT61369 Buclizine 82-95-1 10mg $775 2021-12-16 Buy
American Custom Chemicals Corporation API0009055 BUCLIZINE 95.00% 82-95-1 1G $1358.28 2021-12-16 Buy
Biosynth Carbosynth FT61369 Buclizine 82-95-1 25mg $1737.5 2021-12-16 Buy
Biosynth Carbosynth FT61369 Buclizine 82-95-1 50mg $3250 2021-12-16 Buy
Product number Packaging Price Buy
443556 2.5mg $602 Buy
FT61369 10mg $775 Buy
API0009055 1G $1358.28 Buy
FT61369 25mg $1737.5 Buy
FT61369 50mg $3250 Buy

BUCLIZINE Chemical Properties,Uses,Production

Originator

Longifine,UCB

Uses

Buclizine is an antinauseant.

Definition

ChEBI: An N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups.

Manufacturing Process

1 mol 4-chlorobenzhydril chloride was heated in toluene to reflux with 1 mol ethyl ester of piperazine 1-carboxylic acid at about 150°C in a presence of an excess of triethyl amine. On cooling the triethyl amine hydrochloride was filtered off, a solvent was removed in vacuum and the residue [(4-chlorophenyl)- phenyl-methyl]piperazine carboxylic acid ethyl ester was boiled straight away with potassium hydroxide in ethanol for 48 hours. After removing ethanol in vacuum to dryness, the residue was dissolved in benzene and washed with water. The benzene solution was dried, benzene removed in vacuum. The residue was distilled to give 4-chlorobezhydryl-piperazine. It had given the desired 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)- piperazine, buclizine, by a reaction with 4-tert-butylbenzyl chloride in the presence of any halogen hydrochloride acceptor (triethyl amine, sodium or potassium carbonate and so on). The obtained product had BP: 230°- 240°C/0.001 mm Hg.

brand name

Bucladin (Stuart).

Therapeutic Function

Antihistaminic, Antiallergic, Antinauseant, Tranquilizer, Appetite stimulant

Synthesis

Buclizine is mainly used in the prevention of motion sickness and in combination with analgesics for treatment of migraine.

BUCLIZINE synthesis

129-74-8
82-95-1
Synthesis of BUCLIZINE from BUCLIZINE, DIHYDROCHLORIDE

BUCLIZINE Preparation Products And Raw materials

Raw materials

Paraformaldehyde tert-Butylbenzene 1-Benzylpiperazine BROMO(4-CHLOROPHENYL)PHENYL METHANE Aluminium chloride hexahydrate
4-Chlorobenzhydrylchloride Ethyl N-piperazinecarboxylate 4-tert-Butylbenzyl chloride 1-(4-Chlorobenzhydryl)piperazine 1-(4-TERT-BUTYLBENZYL)PIPERAZINE
BUCLIZINE, DIHYDROCHLORIDE 4-TERT-BUTYLBENZYL ALCOHOL 4-Chlorobenzaldehyde

1of3

Preparation Products

BUCLIZINE Suppliers

Global( 60)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9553 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29474 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616 gksales1@gk-bio.com China 9339 58
Sinoway Industrial co., ltd. 		0592-5800732; +8613806035118 xie@china-sinoway.com China 992 58
CR Corporation Lomited 		fred.wen@crcorporation.cn CHINA 12069 58
Shaanxi Didu New Materials Co. Ltd 		+86-89586680 +86-13289823923 1026@dideu.com China 9309 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33349 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Syntechem Co.,Ltd info@syntechem.com China 12990 57
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-83725681-603 China 4505 50
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Dideu Industries Group Limited 		58
Baoji Guokang Bio-Technology Co., Ltd. 		58
Sinoway Industrial co., ltd. 		58
CR Corporation Lomited 		58
Shaanxi Didu New Materials Co. Ltd 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
Syntechem Co.,Ltd 57
S.Z. PhyStandard Bio-Tech. Co., Ltd. 50

View Lastest Price from BUCLIZINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BUCLIZINE pictures 2024-04-17 BUCLIZINE
82-95-1
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
BUCLIZINE USP/EP/BP pictures 2021-06-18 BUCLIZINE USP/EP/BP
82-95-1
 US $1.10 / g 1g 0.999 100 Tons Min Dideu Industries Group Limited
  • BUCLIZINE pictures
  • BUCLIZINE
    82-95-1
  • US $1.10 / g
  • 99.0% min
  • Shaanxi Dideu Medichem Co. Ltd

82-95-1(BUCLIZINE)Related Search:

Cetirizine dihydrochloride Cetirizine 1-BENZHYDRYLPIPERAZINE 1-(4-METHYLBENZYL)PIPERAZINE 1-(4-CHLOROBENZYL)PIPERAZINE
4-tert-Butylbenzylamine 1-(4-Chlorobenzhydryl)piperazine BUCLIZINE CHLORCYCLIZINE Cyclizine
BUCLIZINE, DIHYDROCHLORIDE,BUCLIZINE 2HCL 1-(4-TERT-BUTYLBENZYL)PIPERAZINE N-(4-ISOPROPYLBENZYL)ETHANAMINE migraleve 1-(4-ETHYL-BENZYL)-PIPERAZINE
BUCLIZINE HCL BUCLIZINE HYDROCHLORIDE IMP. A (BP): 1,4-BIS(4-CHLOROBENZHYDRYL)PIPERAZINE BUCLIZINE HYDROCHLORIDE IMPURITY STANDARD

1of4

Histabuticine Histabutizine Histabutyzine Hitabutyzyne Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)- Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]- piperazine,1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl) Postafen ah2526 Aphilan-R base aphilan-rbase Bucladin Buclifen 1-[4-(Chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]piperrazine AH 2526 1-(4-tert-Butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-piperazin 1-(p-tert-Butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)piperazine Buclozin Buclizine diHCl BUCLIZINE 1-(4-tert-butylbenzyl)-4-(4-chlorobenzhydryl)piperazine Buclizinebase Buclizine (base and/or unspecified salts) 82-95-1 1129-74-8 C28H33ClN2