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L-Pyroglutamamide

CAS No.
16395-57-6
Chemical Name:
L-Pyroglutamamide
Synonyms
L-PYROGLUTAMAMIDE;5-oxo-l-prolamide;5-Oxo-L-prolinamide;L-Pyroglutamamide USP/EP/BP;(2S)-5-oxopyrrolidine-2-carboxamide;(2S)-5-Oxo-2α-pyrrolidinecarboxamide;2-Pyrrolidinecarboxamide, 5-oxo-, (2S)-
CBNumber:
CB9117923
Molecular Formula:
C5H8N2O2
Molecular Weight:
128.13
MDL Number:
MFCD00037888
MOL File:
16395-57-6.mol
Last updated:2025-07-24 18:13:40
Product description Number Pack Size Price
(S)-5-Oxopyrrolidine-2-carboxamide 95+% ee AS16244 1g $366
L-PYROGLUTAMAMIDE 95.00% AAA0006230 5MG $502.99
L-PYROGLUTAMAMIDE 95.00% AAA0006230 1G $675.15
L-Pyroglutamamide V0040 250mg $207
(S)-5-oxopyrrolidine-2-carboxamide 95% CM129671 1g $282

L-Pyroglutamamide Properties

Melting point 148-150 °C(Solv: methanol (67-56-1))
Boiling point 515.9±39.0 °C(Predicted)
Density 1.285±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 14.90±0.40(Predicted)
Appearance White to off-white Solid
optical activity Consistent with structure

SAFETY

Risk and Safety Statements

L-Pyroglutamamide price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS16244 (S)-5-Oxopyrrolidine-2-carboxamide 95+% ee 16395-57-6 1g $366 2021-12-16 Buy
American Custom Chemicals Corporation AAA0006230 L-PYROGLUTAMAMIDE 95.00% 16395-57-6 5MG $502.99 2021-12-16 Buy
American Custom Chemicals Corporation AAA0006230 L-PYROGLUTAMAMIDE 95.00% 16395-57-6 1G $675.15 2021-12-16 Buy
AK Scientific V0040 L-Pyroglutamamide 16395-57-6 250mg $207 2021-12-16 Buy
Chemenu CM129671 (S)-5-oxopyrrolidine-2-carboxamide 95% 16395-57-6 1g $282 2021-12-16 Buy
Product number Packaging Price Buy
AS16244 1g $366 Buy
AAA0006230 5MG $502.99 Buy
AAA0006230 1G $675.15 Buy
V0040 250mg $207 Buy
CM129671 1g $282 Buy

L-Pyroglutamamide Chemical Properties,Uses,Production

Synthesis

Methyl L-pyroglutamate

4931-66-2

L-Pyroglutamamide

16395-57-6

GENERAL METHOD: L-Pyroglutamic acid methyl ester (10 mmol) was dissolved in a mixed NH3[aq]/N2H4[aq] solution (50 mL) at room temperature and the reaction was stirred for 12 hours. Subsequently, the reaction mixture was allowed to stand at -10 °C for 24 h to promote crystallization. The resulting crystals were washed sequentially with ethanol and ether and dried with anhydrous MgSO4. The crude product was purified by fast column chromatography on silica gel with the eluent methanol/dichloromethane (1:6, v/v), resulting in the pure (S)-5-oxopyrrolidine-2-carboxamide in white solid form.

References

[1] Tetrahedron, 1995, vol. 51, # 3, p. 801 - 810
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 16, p. 4644 - 4649

98-79-3
16395-57-6
Synthesis of L-Pyroglutamamide from L-Pyroglutamic acid

L-Pyroglutamamide Preparation Products And Raw materials

Raw materials

Preparation Products

L-Pyroglutamamide Suppliers

Global( 46)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63687 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29798 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 20284 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
DAYANG CHEM (HANGZHOU) CO.,LTD
+86-88938639 +86-17705817739 info@dycnchem.com China 53899 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
DONBOO AMINO ACID COMPANY
+8618051385538 donboo@donboo.com China 9363 58
Adamas Reagent, Ltd. 400-6009262 16621234537 chenyj@titansci.com China 14101 59

View Lastest Price from L-Pyroglutamamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-5-Oxopyrrolidine-2-carboxamide pictures 2020-01-10 (S)-5-Oxopyrrolidine-2-carboxamide
16395-57-6
US $1.00 / g 1g ≥98% g/kg/Ton Career Henan Chemical Co
5-oxo-l-prolamide L-PYROGLUTAMAMIDE (2S)-5-Oxo-2α-pyrrolidinecarboxamide 5-Oxo-L-prolinamide 2-Pyrrolidinecarboxamide, 5-oxo-, (2S)- L-Pyroglutamamide USP/EP/BP (2S)-5-oxopyrrolidine-2-carboxamide 16395-57-6