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Tetramethylammonium chloride

Catalyst of Organic synthesis Electrolytic preparation of tetramethylammonium hydroxide The preparation of PHBHQ type thermoset Liquid crystalline epoxy resin (LCER) Uses
Tetramethylammonium chloride
Tetramethylammonium chloride
CAS No.
75-57-0
Chemical Name:
Tetramethylammonium chloride
Synonyms
TMA;50g;TMAC;TMACL;usafan-8;USAF AN-8;N1,1,1,1Cl;tetraminechloride;Tetramethylammoniumchlorid;tetramethyl-ammoniuchloride
CBNumber:
CB9118809
Molecular Formula:
C4H12ClN
Formula Weight:
109.6
MOL File:
75-57-0.mol

Tetramethylammonium chloride Properties

Melting point:
>300 °C(lit.)
Boiling point:
165.26°C (rough estimate)
Density 
1,17 g/cm3
refractive index 
1.5320 (estimate)
storage temp. 
Store at RT.
solubility 
methanol: 0.1 g/mL, clear, colorless
form 
Hygroscopic Crystalline Powder
color 
White to ivory
PH
6-8 (100g/l, H2O, 20℃)
Water Solubility 
>60 g/100 mL (20 ºC)
Sensitive 
Hygroscopic
λmax
λ: 260 nm Amax: 0.02
λ: 280 nm Amax: 0.02
BRN 
2496575
Stability:
Stable. Incompatible with strong oxidizing agents, water. Hygroscopic.
CAS DataBase Reference
75-57-0(CAS DataBase Reference)
NIST Chemistry Reference
Tetramethylammonium chloride(75-57-0)
EPA Substance Registry System
Methanaminium, N,N,N-trimethyl-, chloride(75-57-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,Xn
Risk Statements  21-25-36/37/38-20/21/22
Safety Statements  26-36/37-45-37/39-28A-28-36
RIDADR  UN 2811 6.1/PG 2
WGK Germany  1
RTECS  BS7700000
3-10
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29239000
Toxicity LD50 orally in Rabbit: 50 mg/kg LD50 dermal Rat 537 mg/kg
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P309 IF exposed or if you feel unwell:
P310 Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Tetramethylammonium chloride price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 74202 Tetramethylammonium chloride for ion pair chromatography, ≥99.0% (AT) 75-57-0 50g-f $56.6 2018-11-13 Buy
Sigma-Aldrich 74202 Tetramethylammonium chloride for ion pair chromatography, ≥99.0% (AT) 75-57-0 250g-f $224 2018-11-13 Buy
TCI Chemical T0136 Tetramethylammonium Chloride >98.0%(T) 75-57-0 25g $15 2018-11-22 Buy
TCI Chemical T0136 Tetramethylammonium Chloride >98.0%(T) 75-57-0 500g $51 2018-11-22 Buy
Alfa Aesar A13288 Tetramethylammonium chloride 97% 75-57-0 1000g $106 2018-11-20 Buy

Tetramethylammonium chloride Chemical Properties,Uses,Production

Catalyst of Organic synthesis

Tetramethylammonium chloride is the phase transfer catalyst in organic synthesis phase with its catalytic activity being stronger than triphenylphosphine and triethylamine. At room temperature, it is a white crystalline powder, and is volatile, irritant, and easy to absorb moisture. It is easily soluble in methanol, soluble in water and hot ethanol but insoluble in ether and chloroform. Being heated to above 230 °C causes its decomposition into trimethylamine and methyl chloride. Median lethal dose (mice, intraperitoneal) is around 25mg/kg. It is also used for the synthesis of liquid crystal epoxy compound, and Pope and polarographic analysis, as well as electronic industry.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Electrolytic preparation of tetramethylammonium hydroxide

Tetramethylammonium hydroxide is a kind of organic base, and has a broad range of application in the field of both industry and scientific research.
In our own country, it is mainly used as the catalyst in the synthesis of organic silicon products, such as synthetic silicone oil, silicone rubber, and silicone resin. Although it has a low usage amount, but it can significantly affect both the yield and quality of the product.
In abroad, it is mainly used for polyester-based polymers, textiles, plastics, food, leather, wood processing, electroplating, and some kinds of microorganisms.
Now tetramethylammonium hydroxide has entered the advanced technology areas. For example, in the field of manufacturing industry of electronic circuit and microscopic sheets production, it can be used as the cleaning agent of integrated circuit board as well as the anisotropic corrosive agents of the Si-SiO2 interface in semiconductor microfabrication technique. With the development of science and technology, the requirements of this type of chemicals are also increasing, posing higher requirements for both the quality and the quantity of the tetramethylammonium hydroxide.
The basic principle of using electrolytic method for preparation of tetramethylammonium hydroxide is that the aqueous solution of tetramethylammonium chloride in the anode compartment of the electrolytic bath, under the action of the electric force, has its chloride ions migrate to the direction of anode until discharge of anode occurs to generate chlorine. Meanwhile, because of the selective permeability of the ion-exchange membrane, chloride can’t penetrate through the ion-exchange membrane through diffusion. Instead, only tetramethylammonium ions can selectively penetrate into the cathode compartment through, and be enriched over there. The water molecule in the electrolyzer cathode chamber is decomposed into hydrogen and hydroxyl ions. The latter one exactly binds to the tetramethylammonium ions migrated from the anode chamber to generate tetramethylammonium hydroxide. With the increase of electricity, tetramethylammonium hydroxide concentration continues to improve, finally achieving the desired final concentration of crude.
The anodic electrochemical reaction is:
(CH3) 4NCl → (CH3) 4N ++ Clˉ2Clˉ-2e → Cl2 ↑
The cathodic electrochemical reaction is:
H2O → H + + OHˉ (CH3) 4N ++ OHˉ → (CH3) 4NOH 2H ++ 2e → H2 ↑
The total reaction is:
2 (CH3) 4NCl + 2H2O → 2 (CH3) 4NOH + H2 ↑ + Cl2 ↑
The hydrogen generated during electrolysis is vented with the resulting chlorine absorbed by alkaline solution to generate sodium hypochlorite which is major raw materials for producing bleach.
Therefore, this method of producing tetramethylammonium hydroxide is simple with high purity and causing no environmental pollution.

The preparation of PHBHQ type thermoset Liquid crystalline epoxy resin (LCER)

Use toluene as the solvent, concentrated sulfuric acid and boric acid as the catalyst, add into the three-necked flask of equal amount of hydroxybenzoic acid and 1,4-hydroquinone, have reaction at 120~130 °C for 6 h; after cooling, repeatedly wash with distilled water, and obtain the p-hydroxybenzoic acid p-hydroquinone ester after vacuum dry (white solid, yield 87.5%).
Dissolve the above product in an excess amount of epichlorohydrin, further add tetramethylammonium chloride and have reaction at 60~70 °C for 10 h; add drop wise of excess amount of aqueous 45% NaOH solution (the addition takes 6 h). Excess amount epichlorohydrin was distilled off under reduced pressure; wash the reaction mixture with acetone-methanol mixed solution for crystallization; it is further subject to vacuum drying to obtain a white PHBHQ-type thermosetting liquid crystalline epoxy resin (with the yield being 37.5%). Mix PHBHQ and hardener stoichiometrically for heating and melting, casting with the curing process being 90 ℃ × 1h; 120 ℃ × 2h; 150 ℃ × 2h; 180 ℃ × 2h.

Uses

1. It can be used as polarographic analysis reagents which is widely used in the electronics industry.
2. Tetramethylammonium chloride is the phase transfer catalyst in organic synthesis with its catalytic activity being stronger than triphenylphosphine and triethylamine. At room temperature, it is a white crystalline powder, and is volatile, irritant, and easy to absorb moisture. It is easily soluble in methanol, soluble in water and hot ethanol but insoluble in ether and chloroform. Being heated to above 230 °C causes its decomposition into trimethylamine and methyl chloride. Median lethal dose (mice, intraperitoneal) is around 25mg/kg. It is also used for the synthesis of liquid crystal epoxy compound, and Pope and polarographic analysis, as well as electronic industry.

Chemical Properties

white crystals

Uses

Chemical intermediate, catalyst, inhibitor.

Safety Profile

Poison by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx, NH3, and Cl-. See also CHLORIDES.

Purification Methods

Crystallise the chloride from EtOH, EtOH/CHCl3, EtOH/diethyl ether, acetone/EtOH (1:1), isopropanol or water. Traces of the free amine can be removed by washing with CHCl3. [Beilstein 4 IV 145.]

Tetramethylammonium chloride Preparation Products And Raw materials

Raw materials

Preparation Products


Tetramethylammonium chloride Suppliers

Global( 303)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22058 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 fandachem@gmail.com CHINA 1966 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1583 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20001 58
Wuhan Greatwall chemical Co,.LTD 400-027-6116 027-86647488
027-86647499 sales@chemgreatwall.com China 1718 55
Wuxi QianFeng Chemical Technology Co., Ltd. 0510-82860650 QQ:125867945
0510-82025215 qfhg@qianfengchem.com China 31 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40399 62

View Lastest Price from Tetramethylammonium chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-18 Tetramethylammonium chloride
75-57-0
US $1.00 / kg 1kg 99% Customized career henan chemical co

Tetramethylammonium chloride Spectrum


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