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1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)-

1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)- Structure
1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)- structure
CAS No.
2760881-74-9
Chemical Name:
1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)-
Synonyms
BRD0639 ，E1007;BRD0639, 10 mM in DMSO;1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)-
CBNumber:
CB912060279
Molecular Formula:
C21H22ClN5O4S
Molecular Weight:
475.95
MDL Number:
MOL File:
2760881-74-9.mol
Last updated:2025-05-16 17:41:54
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1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)- Properties

Density 1.41±0.1 g/cm3(Predicted)
pka 10.63±0.50(Predicted)
form Solid
color Light yellow to brown

1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)- Chemical Properties,Uses,Production

Uses

BRD0639 is a first-in-class inhibitor of the PRMT5-substrate adaptor interaction. BRD0639 is a PRMT5 binding motif (PBM)-competitive agent that can support studies of PBM dependent PRMT5 activities[1].

IC 50

PRMT5

References

[1] McKinney DC, et al. Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J Med Chem. 2021;64(15):11148-11168. DOI:10.1021/acs.jmedchem.1c00507

1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)- Preparation Products And Raw materials

Raw materials

Preparation Products

1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)- Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9364 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24982 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139 orders@jknbiochem.com China 6216 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5686 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd 17316404525 17316404525 209533805@qq.com China 9991 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
BOC Sciences 65
Shanghai Chaolan Chemical Technology Center 58
TargetMol Chemicals Inc. 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd 58
Sangon Biotech (Shanghai) Co.,Ltd. 58

View Lastest Price from 1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BRD0639 pictures 2025-05-16 BRD0639
2760881-74-9
 US $51.00-198.00 / mg 99.85% 10g TargetMol Chemicals Inc.
  • BRD0639 pictures
  • BRD0639
    2760881-74-9
  • US $51.00-198.00 / mg
  • 99.85%
  • TargetMol Chemicals Inc.
BRD0639, 10 mM in DMSO BRD0639 ，E1007 1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)- 2760881-74-9