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Halofuginone hydrobromide

Halofuginone hydrobromide structure

CAS No.: 64924-67-0

Chemical Name:: Halofuginone hydrobromide

Synonyms: STENOROL;Ru-19110;Tempostatin;RU-19110(HBr);Unii-ptc2969mv1;55837-20-2 (free);RU-19110 (hydrobromide);HALOFUGINONEHYDROBROMIDE;Haloperidone hydrobromide;Trans-halofuginone hydrobromide

CBNumber:: CB91230111

Molecular Formula:: C16H17BrClN3O3.HBr

Molecular Weight:: 495.59

MDL Number:: MFCD00946455

MOL File:: 64924-67-0.mol

MSDS File:: SDS

Last updated:2024-03-05 11:29:09

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Halofuginone hydrobromide Properties

Melting point	247° (dec)
storage temp.	Store at -20°C
solubility	Soluble to 100 mM in DMSO.
FDA 21 CFR	558.4
NCI Dictionary of Cancer Terms	halofuginone hydrobromide
FDA UNII	PTC2969MV1
NCI Drug Dictionary	halofuginone hydrobromide

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06,GHS09
Signal word	Danger
Hazard statements	H300+H310+H330-H315-H319-H410
Precautionary statements	P262-P273-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22
RIDADR	UN2811 - class 6.1 - PG 1 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany	3
RTECS	VA2397066

Halofuginone hydrobromide price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	32481	Halofuginone hydrobromide VETRANAL?, analytical standard	64924-67-0	10mg	$513	2024-03-01	Buy
Tocris	1993	Halofuginone hydrobromide ≥98%(HPLC)	64924-67-0	50	$128	2021-12-16	Buy
TRC	H102490	Halofuginone hydrobromide	64924-67-0	1mg	$155	2021-12-16	Buy
TRC	H102490	Halofuginone hydrobromide	64924-67-0	2mg	$180	2021-12-16	Buy
Biosynth Carbosynth	FH23731	Halofuginone hydrobromide	64924-67-0	500mg	$200	2021-12-16	Buy

Product number	Packaging	Price	Buy
32481	10mg	$513	Buy
1993	50	$128	Buy
H102490	1mg	$155	Buy
H102490	2mg	$180	Buy
FH23731	500mg	$200	Buy

Halofuginone hydrobromide Chemical Properties,Uses,Production

regulation

Halofuginone hydrobromide is included in the European Union Register of Feed Additives pursuant to Regulation (EC) No 1831/2003 and is authorized for use in chickens for fattening and turkeys (maximum age 12 weeks) at a dose range of 2–3 mg/kg complete feedingstuffs with a withdrawal time of 5 days[1]. The European Food Safety Authority (EFSA) issued an opinion on the coccidiostat STENOROL® containing 0.6% halofuginone hydrobromide for chickens for fattening and turkeys (EFSA, 2003).

Description

Halofuginone hydrobromide (Halofuginone) is a specific collagen Type I inhibitor that antagonize or inhibit the development of new blood vessels, hence can prevent intimal hyperplasia at a vascular anastomosis. It is used in the treatment or prevention of coccidiosis in both humans and animals.

Chemical Properties

White to Off-White Solid

Uses

Halogenated derivative of Febrifugine. Halofuginone hydrobromide is used as an antiprotozoal (coccidiostat).

Definition

The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.

Biological Activity

Halofuginone hydrobromide is a high affinity competitive prolyl-tRNA synthetase inhibitor (Ki = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.

Toxicology

Halofuginone HBr (Halofuginone hydrobromide) is toxic by inhalation, dermal and ocular routes and is very irritant to both the eye and the skin. It is considered also a skin sensitiser[1].

storage

Store at -20°C

Mode of action

Halofuginone is an an ATP-dependent inhibitor prolyl-tRNA synthetase (Ki of 18.3 nM). Halofuginone attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Blocks expression of MMP2 and inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Also inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.

References

[1] Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, et al. “Safety of a feed additive consisting of halofuginone hydrobromide (STENOROL?) for chickens for fattening and turkeys (Huvepharma N.V.).” EFSA Journal 20 12 (2022).

Halofuginone hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

Halofuginone hydrobromide Suppliers

Global( 112)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Enki Biopharmaceuticals (Shanghai) Limited	+86-0086-2157680326 +8613916707528	yusu@enkibiopharma.com	China	47	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Aktin Chemicals, Inc.	028-85159085	info@aktinchem.com	CHINA	1025	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58

Supplier	Advantage
Amadis Chemical Company Limited	58
Enki Biopharmaceuticals (Shanghai) Limited	58
Chengdu Biopurify Phytochemicals Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Shandong chuangyingchemical Co., Ltd.	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
Career Henan Chemica Co	58
Aktin Chemicals, Inc.	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from Halofuginone hydrobromide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	Halofuginone hydrobromide 64924-67-0	US $10.00 / kg	25kg	99%	10000kg /year	Enki Biopharmaceuticals (Shanghai) Limited
2021-07-13	Halofuginone Hydrobromide 64924-67-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	Halofuginone Hydrobromide 64924-67-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Halofuginone hydrobromide
64924-67-0
US $10.00 / kg
99%
Enki Biopharmaceuticals (Shanghai) Limited

Halofuginone Hydrobromide
64924-67-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Halofuginone Hydrobromide
64924-67-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

64924-67-0(Halofuginone hydrobromide)Related Search:

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1of4

Ru-19110 Tempostatin Unii-ptc2969mv1 rel-7-BroMo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone HydrobroMide trans-(+/-)-7-BroMo-6-chloro-3-[3-(3-hydroxy-2- piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone MonohydrobroMide 7-BroMo-6-chloro-3-(3-((2S,3R)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobroMide HALOFUGINONEHYDROBROMIDE STENOROL 7-Bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one hydrobromide 4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-,hydrobromide (1:1), rel- (+/-)-trans-7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohydrobromide 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(2R,3S)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide, rel- 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+-)- 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+/-)- Trans-halofuginone hydrobromide HALOFUGINONE HBR ((2R,3S) AND (2S,3R) MIXTURE) 55837-20-2 (free) Halofuginone Hydrobromide 64924-67-0 (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide RU-19110(HBr) RU-19110 (hydrobromide) 7-Bromo-6-chloro-3-(3-((2S,3R)-rel-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobromide Haloperidone hydrobromide (3R,4R)-4-(2,5-Difluoro-phenyl)-3-methyl-4-[1,2,4]triazol-1-ylmethyl-oxetan-2-one 64924-67-0 C16H18Br2ClN3O3 Amines Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals