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Halofuginone hydrobromide

Halofuginone hydrobromide
Halofuginone hydrobromide structure
CAS No.
64924-67-0
Chemical Name:
Halofuginone hydrobromide
Synonyms
STENOROL;Ru-19110;Tempostatin;RU-19110(HBr);Unii-ptc2969mv1;55837-20-2 (free);RU-19110 (hydrobromide);HALOFUGINONEHYDROBROMIDE;Trans-halofuginone hydrobromide;Halofuginone Hydrobromide 64924-67-0
CBNumber:
CB91230111
Molecular Formula:
C16H17BrClN3O3.HBr
Formula Weight:
495.59
MOL File:
64924-67-0.mol

Halofuginone hydrobromide Properties

Melting point:
247° (dec)
storage temp. 
Store at -20°C
solubility 
Soluble to 100 mM in DMSO.
form 
neat
FDA 21 CFR
558.4
NCI Dictionary of Cancer Terms
halofuginone hydrobromide
FDA UNII
PTC2969MV1
NCI Drug Dictionary
halofuginone hydrobromide
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS09
Signal word  Danger
Hazard statements  H300+H310+H330-H315-H319-H410
Precautionary statements  P260-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
RIDADR  UN2811 - class 6.1 - PG 1 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany  3
RTECS  VA2397066

Halofuginone hydrobromide price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 32481 Halofuginone hydrobromide VETRANAL?, analytical standard 64924-67-0 10mg $410 2021-03-22 Buy

Halofuginone hydrobromide Chemical Properties,Uses,Production

Description

Halofuginone hydrobromide (Halofuginone) is a specific collagen Type I inhibitor that antagonize or inhibit the development of new blood vessels, hence can prevent intimal hyperplasia at a vascular anastomosis. It is used in the treatment or prevention of coccidiosis in both humans and animals.

Chemical Properties

White to Off-White Solid

Uses

Halogenated derivative of Febrifugine. Halofuginone hydrobromide is used as an antiprotozoal (coccidiostat).

Definition

The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.

Biological Activity

Halofuginone hydrobromide is a high affinity competitive prolyl-tRNA synthetase inhibitor (Ki = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.

Mode of action

Halofuginone is an an ATP-dependent inhibitor prolyl-tRNA synthetase (Ki of 18.3 nM). Halofuginone attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Blocks expression of MMP2 and inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Also inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.

Halofuginone hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products


Halofuginone hydrobromide Suppliers

Global( 77)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132148 58
Hainan Madirui Import and Export Trading Co., Ltd
+8618876637353
123901582@qq.com;303772480@qq.com China 41 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20907 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58

View Lastest Price from Halofuginone hydrobromide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-13 Halofuginone Hydrobromide
64924-67-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 Halofuginone Hydrobromide
64924-67-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-02 Halofuginone Hydrobromide
64924-67-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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