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Phosphatidylserine

Phosphatidylserine
Phosphatidylserine structure
CAS No.
51446-62-9
Chemical Name:
Phosphatidylserine
Synonyms
Glycerol Impurity 3;PHOSPHATIDYLCHOLINE(SOY)(RG);Distearoylphosphatidylserine;Phosphatidylserine fandachem;Phosphatidylserine 51446-62-9;PS(Phosphatidylserine Powder);1,2-Distearoyl phosphatidyl serine;L-ALPHA-PHOSPHATIDYLSERINES, BRAIN;1,2-Distearoyl-sn-3-glycerophosphoserine;1,2-Distearoyl-sn-Glycero-3-Phospho-L-Serine
CBNumber:
CB91236193
Molecular Formula:
C42H82NO10P
Formula Weight:
792.07
MOL File:
51446-62-9.mol

Phosphatidylserine Properties

Boiling point:
816.3±75.0 °C(Predicted)
Density 
1.039±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
pka
1.31±0.50(Predicted)
form 
Liquid
color 
Yellow

Phosphatidylserine price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation LIP0000460 PHOSPHATIDYLSERINE 95.00% 51446-62-9 5MG $591.45 2021-12-16 Buy
Matrix Scientific 100656 (2S)-2-Amino-3-((((R)-2,3-bis(stearoyloxy)propoxy)-(hydroxy)phosphoryl)oxy)propanoic acid 95+% 51446-62-9 250mg $1040 2021-12-16 Buy
American Custom Chemicals Corporation LIP0000460 PHOSPHATIDYLSERINE 95.00% 51446-62-9 100MG $1335.51 2021-12-16 Buy
Arctom AS686934 (2S)-2-Amino-3-((((R)-2,3-bis(stearoyloxy)propoxy)-(hydroxy)phosphoryl)oxy)propanoicacid ≥98% 51446-62-9 1g $10 2021-12-16 Buy
Arctom AS686934 (2S)-2-Amino-3-((((R)-2,3-bis(stearoyloxy)propoxy)-(hydroxy)phosphoryl)oxy)propanoicacid ≥98% 51446-62-9 5g $37 2021-12-16 Buy

Phosphatidylserine Chemical Properties,Uses,Production

Description

Phosphatidylserine (PS) is quite literally a “brain nutrient.” As a matter of fact, this phospholipid is an integral component in the structure of the brain and spinal cord, and is active at cell membranes (including synaptic membrane zones).It plays a key role in cell cycle signaling, specifically in relationship to apoptosis. Studies have provided evidence that PS may promote attention, memory, processing speed, and support overall cognitive health. PS may also support healthy stress and cortisol levels. A significant amount of published clinical research has demonstrated that PS supplementation supports various cognitive parameters in children, including those with ADHD.

Uses

Phosphatidylserine is a brain-boosting supplement. It is a class of phospholipids found in cell membranes. Its levels and location within the brain can affect important signaling pathways for cell survival and communication. Phosphatidylserine includes two fatty acids that can vary from saturated or monounsaturated to polyunsaturated omega-6 and omega-3 versions like docosahexaenoic acid (DHA). Some clinical trials of phosphatidylserine supplements have shown modestly improved cognitive function, but better designed trials reported no benefit.?

Biosynthesis

In mammalian cells, PS is endogenously synthesized via two pathways, both of which exchange the head group of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) for serine, generating PS in both instances (Vance, 2008). PS synthase-1 (PSS1) catalyzes the choline exchange reaction and PS synthase-2 (PSS2) catalyzes the ethanolamine exchange reaction.
PS Synthase 1: Phosphatidylcholine + L-Serine--->Phosphatidylserine + Choline
PS Synthase 2: Phosphatidylethanolamine + L-Serine--->Phosphatidylserine + Ethanolamine
PS, both from endogenous synthesis and exogenous supplementation can be hydrolyzed via two pathways. This occurs via phospholipases, which are located in the plasmalemma (Leventis & Grinstein, 2010). The sn-1acyl chain of PS is hydrolyzed via the action of PSspecific phospholipase A1, while the sn-2 acyl chain of PS is hydrolyzed via PS-specific phospholipase A2, with lysophosphatidylserine (LPS) being formed in both cases. Lysophosphatidylserine produced through the hydrolysis of the sn-2 acyl chain has been implicated in a number of biological processes including mast cell activation and neural differentiation (Hossono, Aoki, Nagai, Bandoh and Ishida (2001); Aoki, Nagai, Hosono, Inoue, and Arai (2002).
stars.library.ucf.edu

Biological Functions

Phosphatidylserine (PS) is a glycerophospholipid consisting of a phosphatidyl group attached to L-serine via a phosphodiester linkage. PS is a critical component of the cellular plasma membrane and accounts for 2-15% of plasma membrane lipid composition, depending on the cell or tissue type. The highest concentrations of PS are found in neuronal tissues, which are critical for maintaining conduction velocity in myelinated neurons, as well as for higher order cognitive skills such as learning and memory. In normal, healthy cells, PS is held in the inner membrane surface (facing the cytosol) by the lipid transporter protein flippase. However, in apoptotic cells, PS molecules ‘shuffle’ between the inner and outer plasma membrane monolayers. When PS molecules flip to the extracellular (outer) surface of the cell membrane, they act as a signal for macrophages to engulf and digest the (apoptotic) cell.

Side effects

When taken by mouth: Phosphatidylcholine is POSSIBLY SAFE when taken by mouth, in a dose up to 30 grams per day for 6 weeks, or up to 6 grams per day for 2 years. When phosphatidylcholine is taken by mouth, it can sometimes cause excessive sweating, stomach upset, and diarrhea.
When given as a shot: Phosphatidylcholine is POSSIBLY SAFE when given as an injection under the skin for up to 5 doses spread 2-4 weeks apart. The injections can cause irritation, swelling, redness, itching, burning, bruising, and pain at the injection site. These side effects usually go away over a period of several days. Sometimes, phosphatidylcholine might cause gastrointestinal upset, like bloating, diarrhea, and nausea.
If phosphatidylcholine is injected directly into a non-cancerous fatty tumor (lipoma), it might cause a reaction that could make the tumor more fibrous, needing surgery to remove it.
When applied to the skin: Phosphatidylcholine is POSSIBLY SAFE when applied to the skin for up to 12 weeks.
www.webmd.com

Safety

Small clinical trials suggest that phosphatidylserine supplements produce no serious adverse effects for elderly patients, although it may reduce blood pressure or increase body weight. Since some supplements are prepared from cow brains, it is theoretically possible for those supplements to transmit prion diseases such as mad cow, though no cases have been reported.?

Source

Food sources of phosphatidylcholine include:
Egg yolks (6,771 mg/100g)
Pig liver (1,668 mg/100g)
Chicken liver (1,120 mg/100g)
Soybeans (917 mg/100g)
Squid (777 mg/100g)
Chicken breast (391 mg/100g)
Beef (408 mg/100g)
Peanuts (270 mg/100g)
Cod (331 mg/100g)
Spinach (37 mg/100g)
Potato (38 mg/100g)
Carrot (23 mg/100g)
Apple (21 mg/100g)
Cow's milk (12 mg/100g)

Phosphatidylserine Preparation Products And Raw materials

Raw materials

Preparation Products


Phosphatidylserine Suppliers

Global( 172)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1275 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9150 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
alice@crovellbio.com China 5942 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58

Related articles

  • Uses of Phosphatidylserine
  • Phosphatidylserine (abbreviated Ptd-L-Ser or PS) is a phospholipid and is a component of the cell membrane.It plays a key role....
  • Dec 28,2021

View Lastest Price from Phosphatidylserine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Phosphatidylserine
51446-62-9
US $10.50 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd
2021-11-17 Phosphatidylserine 51446-62-9
51446-62-9
US $7.50 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-10-27 Phosphatidylserine
51446-62-9
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd

51446-62-9(Phosphatidylserine)Related Search:


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