ChemicalBook >> CAS DataBase List >>Scopolamine butylbromide

Scopolamine butylbromide

Scopolamine butylbromide structure

CAS No.: 149-64-4

Chemical Name:: Scopolamine butylbromide

Synonyms: HYOSCINE BUTYLBROMIDE;buscopan;HYOSCINE N-BUTYL BROMIDE;(1S,2R,4S,5S)-9-butyl-7-[(3-hydroxy-2-phenylpropanoyl)oxy]-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane bromide;scobro;buscol;joscine;donopon;scobron;Stibron

CBNumber:: CB9126868

Molecular Formula:: C21H30BrNO4

Molecular Weight:: 440.37

MDL Number:: MFCD00078561

MOL File:: 149-64-4.mol

MSDS File:: SDS

Last updated:2023-10-13 20:07:10

Request For Quotation

Scopolamine butylbromide Properties

Melting point	142-1440C
alpha	D20 -20.8° (c = 3 in water)
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL
form	powder
color	white
optical activity	[α]25/D 20.8°, c = 3 in H2O(lit.)
CAS DataBase Reference	149-64-4(CAS DataBase Reference)
FDA UNII	0GH9JX37C8
NCI Drug Dictionary	butylscopolamine bromide

Pharmacokinetic data

Protein binding	10%
Excreted unchanged in urine	1-2%
Biological half-life	8 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H332

Precautionary statements

P261-P264-P270-P271-P301+P312-P304+P340+P312

Hazard Codes

Risk Statements

WGK Germany

RTECS

YM3500000

Toxicity

LD50 in mice (mg/kg): 15.6 i.v.; 74 i.p.; 570 s.c.; 3000 orally (Stockhaus, Wick)

NFPA 704

	0
3		0

Scopolamine butylbromide price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S7882	(?)-Scopolamine N-butyl bromide ≥98% (TLC), powder	149-64-4	1g	$54.7	2024-03-01	Buy
Sigma-Aldrich	S7882	(?)-Scopolamine N-butyl bromide ≥98% (TLC), powder	149-64-4	5g	$171	2024-03-01	Buy
Sigma-Aldrich	BP198	Hyoscine butylbromide British Pharmacopoeia (BP) Reference Standard	149-64-4	100MG	$229	2024-03-01	Buy
Cayman Chemical	27223	Scopolamine N-butyl (bromide)	149-64-4	1g	$44	2024-03-01	Buy
Cayman Chemical	27223	Scopolamine N-butyl (bromide)	149-64-4	10g	$299	2024-03-01	Buy

Product number	Packaging	Price	Buy
S7882	1g	$54.7	Buy
S7882	5g	$171	Buy
BP198	100MG	$229	Buy
27223	1g	$44	Buy
27223	10g	$299	Buy

Scopolamine butylbromide Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Originator

Butylscopolamine,China Pharm

Uses

(?)-Scopolamine N-butyl bromide was used as standard in designing a procedure for quantification of compounds using CE-MS.⁸

Uses

Anticholinergic. Antispasmodic

Definition

ChEBI: Butylscopolamine bromide is an organic bromide salt of butylscopolamine. It is an antispasmodic drug which can relieve painful stomach cramps (including those linked with irritable bowel syndrome), bladder and menstrual cramps. It has a role as a muscarinic antagonist and an antispasmodic drug. It is an organic bromide salt and a quaternary ammonium salt. It contains a butylscopolamine.

Manufacturing Process

1300 g of scopolamine base and 350 g of n-butylbromide in 600 ml acetonitrile is heated at 65°C for 160 hours. The oil obtained is dissolved in methanol. The solution is cooled and crystalline scopolamine N-n-butylbromide is filtered. After recrystallization from methanol was obtained scopolamine N-n-butylbromide with melting point 142-144°C and [α]d 20 = -20.5° (3% solution in water); yield 65%.

Therapeutic Function

Anticholinergic, Spasmolytic, Antitussive

Biochem/physiol Actions

Competitive muscarinic acetylcholine receptor antagonist; antispasmodic.

Clinical Use

Symptomatic relief of gastrointestinal or genitourinary disorders due to smooth muscle spasm Bowel colic
Excessive respiratory secretions

target

AChR

Metabolism

The main metabolic pathway is the hydrolytic cleavage of the ester bond. Orally administered hyoscine butylbromide is excreted in the faeces and in the urine. Studies in man show that 2-5% of radioactive doses is eliminated renally after oral, and 0.7-1.6% after rectal administration. Approximately 90% of recovered radioactivity can be found in the faeces after oral administration. The urinary excretion of hyoscine butylbromide is less than 0.1% of the dose. The metabolites excreted via the renal route bind poorly to muscarinic receptors and are therefore not considered to contribute to the effect of the hyoscine butylbromide.

Scopolamine butylbromide synthesis

Synthesis of Scopolamine butylbromide from Methyl bromide and Benzeneacetic acid, α-(hydroxymethyl)-, 9-butyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, [7(S)-(1α,2β,4β,5α,7β)]- (9CI)

Scopolamine butylbromide Preparation Products And Raw materials

Raw materials

Scopolamine 1-Bromobutane Benzeneacetic acid, α-(hydroxymethyl)-, 9-butyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, [7(S)-(1α,2β,4β,5α,7β)]- (9CI)

Preparation Products

Scopolamine butylbromide Suppliers

Global( 429)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12452	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2504	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58

View Lastest Price from Scopolamine butylbromide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-09	Scopolamine butylbromide; Flos?daturae extract 149-64-4	US $0.00 / G	1G	≥99% HPLC	1000KG	Changsha Staherb Natural Ingredients Co., Ltd.
2023-10-14	Scopolamine butylbromide 149-64-4	US $0.00 / kg	1kg	0.99	20tons	Hebei Yanxi Chemical Co., Ltd.
2023-08-11	Aloe emodin 149-64-4	US $50.00 / kg	1kg	99.9%	10000MT	Henan Bao Enluo International TradeCo.，LTD

Scopolamine butylbromide; Flos?daturae extract
149-64-4
US $0.00 / G
≥99% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

Scopolamine butylbromide
149-64-4
US $0.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

Aloe emodin
149-64-4
US $50.00 / kg
99.9%
Henan Bao Enluo International TradeCo.，LTD

Scopolamine butylbromide Spectrum

Scopolamine butylbromide(149-64-4)MS

149-64-4(Scopolamine butylbromide)Related Search:

Dimidium bromide Racanisodamine Allyl bromide Ethidium bromide Rocuronium bromide

Cyhalofop-butyl L-Hyoscyamine Buprofezin 1-Bromobutane Vecuronium bromide

Scopolamine hydrobromide Anisodamine Sodium bromate Scopolamine SCOPOLAMINE N-OXIDE HYDROBROMIDE

Scopolamine Hydrobromide Trihydrate (-)-SCOPOLAMINE SCOPOLAMINE-D3 HYDROBROMIDE Hyoscine Butylbromide

1of4

donopon hyoscinebutobromide hyoscin-n-butylbromid hyoscin-n-butylbromide joscine monospan n-butylhyoscinebromide n-butylhyosciniumbromide n-butylscopolaminiumbromide omide,(-)-tropate scobro scobron scobutil scobutyl scopolaminebromobutylate scopolaminebutobromide scopolaminebutylbromide scopolan sparicon sporamin stilbron tirantil hyoscine butylobromide Hyoscine butyl bromide BP HYOSCINE BUTYLBROMIDE STANDARD ScopolaMine ButylborMide (Hyoscine ButylbroMide) 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-Methyl-, broMide (1:1), (1a,2b,4b,5a,7b)- Hyoscine butylbromide Impurity Ding bromate scopolamine Hyoscinen buty1bromide Ding bromine scopolamine ()-N-Butylscopolamine bromide ()-Scopolamine N-butyl bromide Hyoscine N-butyl bromide (-)-SCOPOLAMINE N-BUTYL BROMIDE CHOLINERGIC ANTAGONIST 3-Oxa-9-azoniatricyclo3.3.1.02,4nonane, 9-butyl-7-(2S)-3-hydroxy-1-oxo-2-phenylpropoxy-9-methyl-, bromide, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)- 1aH,5aH-Tropanium, 8-butyl-6b,7b-epoxy-3a-hydroxy-, bromide, (-)-tropate (8CI) 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 9-butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-, bromide, [7(S)-(1a,2b,4b,5a,7b)]- 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-, bromide, (1a,2b,4b,5a,7b)- (9CI) Sporamin (pharmaceutical) Stibron Tropic acid, (-)-, ester with 8-butyl-6b,7b-epoxy-3a-hydroxy-1a-H,5aH-tropanium bromide (8CI) (-)-Scopolamin-n-butylbromid (-)-SCOPOLAMINE N-BUTYL BROMIDE 99% ButylscopolaMine BR (ScopolaMine butylbroMide) (-)-SCOPOLAMINE N-BUTYL BROMIDE BP 7(S)-(1a,2,4,5a,7)]-9-Butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide (-)-N-Butylscopolamine bromide, Hyoscine N-butyl bromide 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-, bromide, (1a,2b,4b,5a,7b)- (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-9-Butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azonitricyclo[3.3.1.0(2,4)]nonane bromide Scopoamine Butylbromide ButylscopolaMine broMide(ScopolaMine butylbroMide) 7(S)-(1α,2β,4β,5α,7β)]-9-Butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-Methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane BroMide Buthylhyoscine bromide BUTYLMIN SCOPOLAMINI BUTYLBROMIDUM (-)-SCOPOLAMINE N-BUTYL BROMIDE SCOPOLAMINE N-BUTYL BROMIDE (-)-N-BUTYLSCOPOLAMIDE BROMIDE (-)-N-BUTYLSCOPOLAMINE BROMIDE