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Glycopyrronium Bromide

Glycopyrronium Bromide Structure
Glycopyrronium Bromide structure
CAS No.
51186-83-5
Chemical Name:
Glycopyrronium Bromide
Synonyms
Glonium bromide;Glycopyrrolate Impurity 58;GlycopyrroniuM BroMide API;erythro-Glycopyrronium bromide;Glycopyrronium bromide (CHF 5259;Glycopyrronium Bromide / Glycopyrrolate;2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetic acid (triglycine);(R*,S*)-3-[(Cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide;Pyrrolidinium, 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-, bromide, (R*,S*)-;(3S)-3-{[(2R)-2-Cyclopentyl-2-hydroxy-2-phenylacetyl]oxy}-1,1-dimethylpyrrolidinium bromide
CBNumber:
CB91270476
Molecular Formula:
C19H28NO3.Br
Molecular Weight:
0
MDL Number:
MFCD31381925
MOL File:
51186-83-5.mol
Last updated:2024-04-22 09:42:11
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Glycopyrronium Bromide Properties

Melting point 175℃
solubility Freely soluble in water, soluble in ethanol (96 per cent), very slightly soluble in methylene chloride.
InChI InChI=1/C19H28NO3.BrH/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15;/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3;1H/q+1;/p-1/t17-,19-;/s3
InChIKey VPNYRYCIDCJBOM-SCHKGOGONA-M
SMILES [N+]1(C)(C)CC[C@H](OC([C@](C2CCCC2)(O)C2=CC=CC=C2)=O)C1.[Br-] |&1:5,8,r|
FDA UNII V92SO9WP2I

SAFETY

Risk and Safety Statements

HS Code  2933997500

Glycopyrronium Bromide Chemical Properties,Uses,Production

Description

Glycopyrronium bromide or NVA 237 is a once-daily inhaled antimuscarinic bronchodilator newly approved by the European Commission for use in stable COPD. It is characterized by a quaternary ammonium structure, which reduces its oral bioavailability and, consequently, the systematic effects of any swallowed portion of the drug. Animal studies suggest that there are fewer cardiovascular effects compared to tiotropium because of the higher affinity to M3 versus M2 muscarinic receptors. Human studies showed fast onset of action, sustained bronchodilatation for 24 h, reduced dynamic hyperinflation of the lungs, and improved exercise tolerance. Glycopyrronium bromide in COPD airways clinical trial series (GLOW1–3) are the major clinical trials studying the efficacy and safety of glycopyrronium[1].

Chemical Properties

White or almost white, crystalline powder.

Uses

Anticholinergic

Uses

erythro-Glycopyrronium Bromide is used in preparation of diester containing compounds for treating hyperhidrosis.

Definition

ChEBI: (2R,3S)-glycopyrronium bromide is a glycopyrronium bromide that has (2R,3S)-configuration. The racemate, ritropirronium bromide, is used for treatment of chronic obstructive pulmonary disease. It is an enantiomer of a (2S,3R)-glycopyrronium bromide.

Indications

Glycopyrronium bromide is indicated for use as a preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions; to reduce the volume and free acidity of gastric secretions, and to block cardiac vagal inhibitory reflexes during induction of anaesthesia and intubation when indicated. Glycopyrronium bromide may be used intraoperatively to counteract drug-induced or vagal traction reflexes with the associated arrhythmias. Glycopyrronium bromide protects against the peripheral muscarinic effects (e.g., bradycardia and excessive secretions) of cholinergic agents such as neostigmine and pyridostigmine given to reverse the neuromuscular blockade due to non-depolarising muscle relaxants.

Side effects

The following reported adverse reactions are extensions of glycopyrronium bromide’s fundamentalpharmacological actions:
Cardiovascular: Tachycardia, ventricular fibrillation, bradycardia, palpitation and arrhythmia, hypertension, hypotension, cardiac arrest, heart block, prolonged QTc interval.
Dermatological: Flushing and inhibition of sweating. Severe allergic reactions or drug idiosyncrasies including urticaria and other dermal manifestations, pruritus, dry skin.
Gastrointestinal: Nausea, vomiting, dry mouth, constipation, taste alterations, including loss of taste.
Genitourinary: Urinary hesitancy and retention, impotence.
Ocular: Blurred vision due to mydriasis, cycloplegia, photophobia, increased ocular tension.
Nervous System: Inhibition of transmission at neuromuscular junction, headache, nervousness, drowsiness, dizziness, seizure, insomnia, some degree of mental confusion, especially in the elderly, hyperexcitability in children.
Pregnancy and perinatal: Suppression of lactation.
Respiratory System: Respiratory arrest.
General: Hyperpyrexia, bloated feeling, anaphylaxis/anaphylactoid reaction, hypersensitivity. Injection site reactions including pruritus, oedema, erythema, pain have been reported rarely.

References

[1] Alexander G. Mathioudakis, Victoria Chatzimavridou-Grigoriadou, Georgios A. Mathioudakis.“Chapter 16 - Drugs that act on the respiratory tract.” 2014: 241-256.

Glycopyrronium Bromide Preparation Products And Raw materials

Raw materials

Preparation Products

Glycopyrronium Bromide Suppliers

Global( 81)Suppliers
Supplier Tel Email Country ProdList Advantage
Jewim Pharmaceutical (Shandong) Co., Ltd.
+86-15552509998 +86-15621883869 liutf@jewim.com.cn China 251 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118 xie@china-sinoway.com China 992 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Anhui Dexinjia Biopharm Co., Ltd 		+86-531-82375818 +86-15064153060 alice@jndxj.com China 309 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shenzhen Excellent Biotech Co., Ltd. 		13480692018 ramyan@ex-biotech.com CHINA 954 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
Supplier Advantage
Jewim Pharmaceutical (Shandong) Co., Ltd.
58
Sinoway Industrial co., ltd.
58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Anhui Dexinjia Biopharm Co., Ltd 		58
Chongqing Chemdad Co., Ltd 		58
Shenzhen Excellent Biotech Co., Ltd. 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58

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View Lastest Price from Glycopyrronium Bromide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Glycopyrronium Bromide pictures 2024-04-22 Glycopyrronium Bromide
51186-83-5
 US $0.00-0.00 / G 100G 99% 20TONS Sinoway Industrial co., ltd.
erythro-Glycopyrronium bromide pictures 2024-01-02 erythro-Glycopyrronium bromide
51186-83-5
 US $80.00-800.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
Glycopyrronium Bromide pictures 2023-11-27 Glycopyrronium Bromide
51186-83-5
 US $0.00 / KG 1KG 99% 20 TONS Wuhan Senwayer Century Chemical Co.,Ltd

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erythro-Glycopyrronium bromide Pyrrolidinium, 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-, bromide, (R*,S*)- Pyrrolidinium, 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-, bromide, (R*,S*)-(+-)- (R*,S*)-3-[(Cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide GlycopyrroniuM BroMide API (3S)-3-{[(2R)-2-Cyclopentyl-2-hydroxy-2-phenylacetyl]oxy}-1,1-dimethylpyrrolidinium bromide Glycopyrronium bromide (CHF 5259 Glycopyrronium for peak identification (Y0001309)Q: What is Glycopyrronium for peak identification (Y0001309) Q: What is the CAS Number of Glycopyrronium for peak identification (Y0001309) 2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetic acid (triglycine) Glycopyrrolate Impurity 58 Glycopyrronium Bromide / Glycopyrrolate (3S)-rel-3-[[(2R)-2-cyclopentyl-2-hydroxy-2-phenylacetyl]oxy]-1,1-dimethyl-,Pyrrolidinium bromide (1:1) Glonium bromide 51186-83-5