Estramustine
- CAS No.
- 2998-57-4
- Chemical Name:
- Estramustine
- Synonyms
- LEO 275;Estracty;NSC89201;NSC 89201;NSC-89201;Estamustine;Estramustin;ESTRAMUSTINE;Alestramustine;Estramustine USP/EP/BP
- CBNumber:
- CB9127416
- Molecular Formula:
- C23H31Cl2NO3
- Molecular Weight:
- 440.4
- MDL Number:
- MFCD00866377
- MOL File:
- 2998-57-4.mol
- MSDS File:
- SDS
| Melting point | 104-105° |
|---|---|
| alpha | D20 +50° (in dioxane) |
| Boiling point | 565.8±50.0 °C(Predicted) |
| Density | 1.253±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| pka | 15.05±0.40(Predicted) |
| Water Solubility | 1mg/L(30 ºC) |
| CAS DataBase Reference | 2998-57-4(CAS DataBase Reference) |
| FDA UNII | 35LT29625A |
| NCI Dictionary of Cancer Terms | estramustine |
| ATC code | L01XX11 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Estramustine price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E888075 | Estradiol3-[N,N-Bis(2-chloroethyl)carbamate] | 2998-57-4 | 50mg | $160 | 2021-12-16 | Buy |
| TRC | E888075 | Estradiol3-[N,N-Bis(2-chloroethyl)carbamate] | 2998-57-4 | 500mg | $1260 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0024779 | ESTRAMUSTINE 95.00% | 2998-57-4 | 1G | $1319.47 | 2021-12-16 | Buy |
| AK Scientific | E663 | Estramustine | 2998-57-4 | 5mg | $35 | 2021-12-16 | Buy |
| Ark Pharm | P000105936 | Estramustine 99+% | 2998-57-4 | 100mg | $390 | 2021-12-16 | Buy |
Estramustine Chemical Properties,Uses,Production
Uses
Estradiol 3-[N,N-Bis(2-chloroethyl)carbamate] is used treatment of breast cancer. Also used in the treatment of prostate cancer.
Uses
Antineoplastic.
Definition
ChEBI: A carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid.
Indications
Estramustine phosphate sodium (Emcyt) is a hybrid structure combining estradiol and a nitrogen mustard in a single molecule. The drug has been approved for use in prostatic carcinomas and will produce clinical remissions in one-third of patients who have failed to respond to previous estrogen therapy. The mechanism of action of estramustine is not well defined, but it does not appear to require either alkylation of DNA or the presence of estrogen receptors in tumor cells. Nonetheless, the toxicities of the drug are similar to those of estrogen therapy: breast tenderness and enlargement (gynecomastia), fluid retention, mild nausea, and an increased risk of thrombophlebitis and pulmonary embolism.The drug is not myelosuppressive.
Biological Functions
Estramustine has a low affinity for the βm tubulin isotype, which often is overexpressed in estramustineresistant prostatic neoplasms as one defense against this therapeutic intervention.
Mechanism of action
Because this anticancer agent contains a carbamylated nitrogen mustard moiety, it is most commonly classified as a DNA alkylator; however, it is now known that its primary mechanism of antineoplastic action is inhibition of mitosis.
Estramustine Preparation Products And Raw materials
Estramustine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15747 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18458 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
View Lastest Price from Estramustine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-06 | Estramustine USP/EP/BP
2998-57-4
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Estramustine USP/EP/BP
2998-57-4
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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