Estradiol benzoate
- CAS No.
- 50-50-0
- Chemical Name:
- Estradiol benzoate
- Synonyms
- ODB;MEE;Oestradiol benzoate;EBZ;folone;17β-Estradiol benzoate;Estradiol monobenzoate;(17beta)-Estra-1,3,5(10)-triene-3,17-diol 3-benzoate;(8R,9S,13S,14S,17S)-17-hydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl benzoate;ESTON-B
- CBNumber:
- CB9131644
- Molecular Formula:
- C25H28O3
- Molecular Weight:
- 376.5
- MDL Number:
- MFCD00003692
- MOL File:
- 50-50-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 191-198 °C(lit.) |
|---|---|
| alpha | D25 +58 to +63° (c = 2 in dioxane) |
| Boiling point | 465.03°C (rough estimate) |
| Density | 1.0493 (rough estimate) |
| refractive index | 1.5460 (estimate) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in acetone, slightly soluble in methanol. |
| form | Solid |
| pka | 15.06±0.40(Predicted) |
| color | White |
| Water Solubility | 0.4mg/L(25 ºC) |
| Merck | 3703 |
| BRN | 3107526 |
| InChIKey | UYIFTLBWAOGQBI-BZDYCCQFSA-N |
| SMILES | [H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OC(=O)c5ccccc5)ccc24 |
| CAS DataBase Reference | 50-50-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 1S4CJB5ZGN |
| NIST Chemistry Reference | Estradiol benzoate(50-50-0) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H351-H360FD |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
| PPE | Eyeshields, Gloves, type P3 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 60-61-40 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | KG4050000 |
| F | 8 |
| HS Code | 29372319 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Carc. 2 Repr. 1B |
Estradiol benzoate price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000852 | Estradiol benzoate for system suitability European Pharmacopoeia (EP) Reference Standard | 50-50-0 | 10 mg | $220 | 2026-04-30 | Buy |
| Sigma-Aldrich | E8515 | β-Estradiol 3-benzoate ≥97% | 50-50-0 | 1g | $127 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR2858 | Estradiol Benzoate certified reference material, pharmaceutical secondary standard | 50-50-0 | 500MG | $317 | 2026-04-30 | Buy |
| Sigma-Aldrich | E1600000 | Estradiol benzoate European Pharmacopoeia (EP) Reference Standard | 50-50-0 | 250 mg | $241 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP396 | Estradiol benzoate British Pharmacopoeia (BP) Reference Standard | 50-50-0 | 50MG | $241 | 2026-04-30 | Buy |
Estradiol benzoate Chemical Properties, Uses, Production
Chemical Properties
White solid
Uses
antiacne, antineoplastic
Uses
Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the treatment of lesions produced by diminution of bodily production of estrogens.
Definition
ChEBI: A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.
Clinical Use
Estradiol is a semisynthetic estrogen compound. Its effects will mimic that of estrogen in animals. The most common use in small animals has been to terminate pregnancy.
Estradiol benzoate also has been used to terminate pregnancy (5-10 mg/kg divided into two or three SQ injections). Estradiol cypionate formulation had high efficacy (95%), but it had serious adverse effects and is not recommended. Estradiol cypionate is longer acting and more potent than other estrogen formulations. Estradiol valerate injection (20 mg/mL) is also available for human medicine to treat hypoestrogenism.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human reproductive effects by intramuscular route: menstrual cycle changes and disorders. Experimental reproductive effects. Mutation data reported. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTRADIOL.
Estradiol benzoate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CHONGQING CHENCHENG PHARMACEUTICAL CO.，LTD. | 15310426561 | lf19823605252@163.com | China | 145 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 45000 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Latest Price from Estradiol benzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-09 | Estradiol benzoate
50-50-0
|
100g | 97.0~103.0%; USP43 | 800kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-10-08 | estradiol benzoate
50-50-0
|
USP, GMP | 2tons | Sinoway Industrial co., ltd. | |||
 |
2026-08-25 | Estradiol Benzoate
50-50-0
|
1kg | 0.99 | 1000kg | Shaanxi Xianhe Biotech Co., Ltd |
-
- Estradiol benzoate
50-50-0
- $0.00
- 97.0~103.0%; USP43
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- estradiol benzoate
50-50-0
- USP, GMP
- Sinoway Industrial co., ltd.
-
- Estradiol Benzoate
50-50-0
- $0.00
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
