illudin S
- CAS No.
- 1149-99-1
- Chemical Name:
- illudin S
- Synonyms
- CS-1385;Illudin;Lampterol;Illusin S;Lunamycin;illudin S;NSC 400979;Illudine S;NSC-626369;(1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1'-cyclopropane]-4-one
- CBNumber:
- CB91318110
- Molecular Formula:
- C15H20O4
- Molecular Weight:
- 264.32
- MDL Number:
- MFCD00870487
- MOL File:
- 1149-99-1.mol
- MSDS File:
- SDS
| Melting point | 124-126℃ |
|---|---|
| Boiling point | 327.55°C (rough estimate) |
| Density | 1.0583 (rough estimate) |
| refractive index | 1.4300 (estimate) |
| storage temp. | -20°C, Inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | A light yellow solid |
| pka | 12.50±0.70(Predicted) |
| FDA UNII | EWJ0GY2H7X |
illudin S price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17451 | Illudin S ≥98% | 1149-99-1 | 1mg | $303 | 2024-03-01 | Buy |
| Cayman Chemical | 17451 | Illudin S ≥98% | 1149-99-1 | 5mg | $1208 | 2024-03-01 | Buy |
| ApexBio Technology | C4732 | IlludinS | 1149-99-1 | 5mg | $1381 | 2021-12-16 | Buy |
| ApexBio Technology | C4732 | IlludinS | 1149-99-1 | 1mg | $345 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0003821 | ILLUDIN S 95.00% | 1149-99-1 | 5MG | $495.42 | 2021-12-16 | Buy |
illudin S Chemical Properties,Uses,Production
Description
Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.
Uses
Illudin S is a potent antitumor sesquiterpene.
Uses
Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.
Definition
ChEBI: Illudin S is a sesquiterpenoid.
illudin S Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 | wendy@huidabiotech.com | CHINA | 87 | 58 |
| Shanghai Minbiotech Co., Ltd. | +8617315815539 | sales@minbiotech.com | CHINA | 129 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |