dinervonylphosphatidylcholine

Uses

Dinervonoyllecithin is used in a a cannulation device for administering ophthalmic delivery and ophthalmic drug compositions.

Uses

24:1 (Cis) PC has been used:

• in the preparation of multivesicular liposomes (DepoFoam) formulation with protein or peptide drugs
• in the formation of planar bilayer lipid membranes
• for analyzing the phase transition of giant unilamellar dinervonoylphosphocholine (DNPC) vesicles by N-4-nitrobenz-2-oxa-1,3-diazol (NBD)-labelled fluorophore in confocal microscopy

Uses

24:1 (Cis) PC (1,2-dinervonoyl-sn-glycero-3-phosphocholine) may be used in planar bilayer lipid membranes (BLMs) to study the effect of lipid chain length on single-channel properties of C-terminal colicin peptide (P178). It may also be used in planar bilayers to explore the single channel activities of BKCa (hSlo α-subunit) channels.

Definition

ChEBI: PC(24:1(15Z)/24:1(15Z)) is a 1,2-diacyl-sn-glycero-3-phosphocholine.

General Description

24:1 (Cis) PC (1,2-dinervonoyl-sn-glycero-3-phosphocholine) has two 24 carbon fatty acid chains, each having one cis double bond at the 15th carbon.

Biochem/physiol Actions

Phosphatidylcholine (PC) is essential for the structure and functions of eukaryotic membranes. PC is essential for very low-density lipoprotein synthesis in liver cells. PC is the substrate for sphingomyelin. PC is the major source of cell signaling molecules. PC is the structural component of many human parasites and helps in cell invasion.