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DROPERIDOL

DROPERIDOL
DROPERIDOL structure
CAS No.
548-73-2
Chemical Name:
DROPERIDOL
Synonyms
R 474;r4749;Dridol;Halkan;Inoval;R 4749;Inappin;Inapsin;Innovan;Innovar
CBNumber:
CB9145418
Molecular Formula:
C22H22FN3O2
Formula Weight:
379.43
MOL File:
548-73-2.mol

DROPERIDOL Properties

Melting point:
148-149°C
Density 
1.2154 (estimate)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in dimethylformamide and in methylene chloride, sparingly soluble in ethanol (96 per cent).
form 
neat
pka
7.64(at 25℃)
Water Solubility 
4.1mg/L(30 ºC)
CAS DataBase Reference
548-73-2(CAS DataBase Reference)
FDA UNII
O9U0F09D5X
NCI Dictionary of Cancer Terms
droperidol
NCI Drug Dictionary
droperidol
ATC code
N05AD08
EPA Substance Registry System
2H-Benzimidazol-2-one, 1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro- (548-73-2)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
RIDADR  3249
WGK Germany  3
RTECS  DE2100000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933995800
Toxicity LD50 oral in rat: 750mg/kg

DROPERIDOL price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D1414 Droperidol 548-73-2 1g $131 2021-12-16 Buy
Sigma-Aldrich D3100000 Droperidol European Pharmacopoeia (EP) Reference Standard 548-73-2 $190 2021-12-16 Buy
Sigma-Aldrich PHR2585 Droperidol 548-73-2 500MG $199 2021-12-16 Buy
Sigma-Aldrich 1229001 Droperidol United States Pharmacopeia (USP) Reference Standard 548-73-2 250mg $366 2021-12-16 Buy
Cayman Chemical 18884 Droperidol ≥98% 548-73-2 1g $90 2021-12-16 Buy

DROPERIDOL Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Originator

Dehydrobenzperidol,Janssen,W. Germany,1963

Uses

A D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.

Uses

H2 antihistamine

Uses

A D1DR and D2DR inhibitor.

Uses

The neuroleptic droperidol possesses antipsychotic, sedative, and antishock action. It potentiates the action of drugs for narcosis. In psychiatric practice, droperidol is used for psychomotor excitement and hallucinations. The principal use of this drug lies in anesthesiology for neuroleptanalgesia in combination with fentanyl. It is used in premedication as well as in surgical operations and post-operational circumstances.

Definition

ChEBI: An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeo .

Manufacturing Process

A mixture of 10 parts of γ-chloro-4-fluorobutyrophenone, 5.5 parts of 1- (1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone, 4 parts of sodium carbonate, and 0.1 part of potassium iodide in 176 parts of 4-methyl-2- pentanone is stirred and refluxed for 64 hours. The cooled reaction mixture is filtered and the solvent is evaporated from the filtrate to leave an oily residue which is dissolved in toluene. The toluene solution is filtered and the solvent is evaporated. The resultant residue is recrystallized from a mixture of 32 parts of ethyl acetate and 32 parts of diisopropyl ether to give 1-[1-[(4-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone hydrate melting at about 145°-146.5°C.

brand name

Inapsine (Akorn);Dehydrobenzperidol;Diaperidol;Inopsin.

Therapeutic Function

Tranquilizer

General Description

Droperidol, 1-{1-[3-(p-fluorobenzoyl)propyl]-1,2, 3,6-tetrahydro-4-pyridyl}-2-benzimidazolinone(Inapsine), may be used alone as a preanestheticneuroleptic or as an antiemetic. Because of its very shortactingand highly sedating properties, its most frequent useis in combination (Innovar) with the narcotic agent fentanyl(Sublimaze) preanesthetically.

General Description

Droperidol, 1-1-[3-(p-fluorobenzoyl)propyl]-1,2,[3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone(Inapsine). Centrally acting acetylcholinesteraseinhibitors may increase the risk of antipsychotic-relatedEPS. CNS depressants may produce additive sedativeeffects (benzodiazepines, barbiturates, antipsychotics,ethanol, opiates, and other sedative medications).Droperidol in combination with certain forms of inhalationanesthetics may produce peripheral vasodilatation and hypotension.Metoclopramide may increase the risk of EPSproduced by droperidol.

Biochem/physiol Actions

D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.

Chemical Synthesis

Droperidol, 1-[1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6,4-piridyl]-2-benzymidazolinone (6.3.11), is synthesized from 1-benzyl-3-carbethoxypiperidin-4-one (3.1.47), which is reacted with o-phenylendiamine. Evidently, the first derivative that is formed under the reaction conditions, 1,5-benzdiazepine, rearranges into 1-(1-benzyl-1,2,3,6- tetrahydro-4-piridyl)-2-benzymidazolone (6.3.9). Debenzylation of the resulting product with hydrogen over a palladium catalyst into 1-(1,2,3,6-tetrahydro-4-piridyl)-2-benzimidazolon (6.3.10) and subsequent alkylation of this using 4′-chloro-4-fluorobutyrophenone (6.3.4) yields droperidol (6.3.11) [47–49].

DROPERIDOL Preparation Products And Raw materials

Raw materials

Preparation Products


DROPERIDOL Suppliers

Global( 166)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3284 55
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
career henan chemical co
15093356674 0371-55982848
0086-371-86658258 factory@coreychem.com CHINA 29863 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19231 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
0551-65418697 sales@tnjchem.com CHINA 37441 58
ShenZhen Ipure Biology import and export company co.,ltd
18071025641 18071025641
eric@ipurechemical.com CHINA 11336 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58

View Lastest Price from DROPERIDOL manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-24 DROPERIDOL USP/EP/BP
548-73-2
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
2021-07-13 DROPERIDOL
548-73-2
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09 DROPERIDOL
548-73-2
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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