Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Structure
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline structure
CAS No.
641571-11-1
Chemical Name:
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
Synonyms
NILOTINIB IMPURITY 24;Nilotinib Intemediate 1;Nilotinib EP Impurity A;Nilotinib Amino Impurity;Nilotinib??Intermediates?A;Nilotinib genotoxic impurity 1;Nilotinib Hydrochloride Monohydrate Impurity A;Nilotinib Impurity 15(Nilotinib EP Impurity A);3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl);Nilotinib Hydrochloride Monohydrate EP Impurity A
CBNumber:
CB91503963
Molecular Formula:
C11H10F3N3
Molecular Weight:
241.21
MDL Number:
MFCD11846236
MOL File:
641571-11-1.mol
Last updated:2024-03-28 16:41:05
Request For Quotation

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Properties

Melting point 124-126°C
Boiling point 372.14℃[at 101 325 Pa]
Density 1.35
vapor pressure 0Pa at 25℃
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
form powder to crystal
color White to Light gray to Light yellow
Water Solubility 228.6mg/L at 25℃
InChI InChI=1S/C11H10F3N3/c1-7-5-17(6-16-7)10-3-8(11(12,13)14)2-9(15)4-10/h2-6H,15H2,1H3
InChIKey WWTGXYAJVXKEKL-UHFFFAOYSA-N
SMILES C1(N2C=C(C)N=C2)C=C(N)C=C(C(F)(F)F)C=1
LogP 2.42
CAS DataBase Reference 641571-11-1(CAS DataBase Reference)
FDA UNII 5LLI0Q7APP

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H318
Precautionary statements  P280-P301+P310-P305+P351+P338
Risk Statements  41
Safety Statements  26-39
RIDADR  2811
HazardClass  6.1
PackingGroup  Ⅲ
HS Code  2933299090

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich VBP00135 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 641571-11-1 1g $482 2024-03-01 Buy
TCI Chemical M2634 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline >98.0%(GC)(T) 641571-11-1 1g $33 2024-03-01 Buy
TCI Chemical M2634 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline >98.0%(GC)(T) 641571-11-1 5g $109 2024-03-01 Buy
TRC M313065 3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline 641571-11-1 25mg $145 2021-12-16 Buy
SynQuest Laboratories 3H30-3-T2 3-Amino-5-(4-methyl-1H-imidazol-1-yl)benzotrifluoride 641571-11-1 250mg $150 2021-12-16 Buy
Product number Packaging Price Buy
VBP00135 1g $482 Buy
M2634 1g $33 Buy
M2634 5g $109 Buy
M313065 25mg $145 Buy
3H30-3-T2 250mg $150 Buy

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Chemical Properties,Uses,Production

Description

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is a pharmaceutical intermediate component used in the preparation of Nilotinib for the treatment of a variety of leukaemias, including chronic myeloid leukaemia (CML).

Chemical Properties

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is a white to light grey to light yellow powder to crystals with a melting point of 130 °C.

Uses

Intermediate in the preparation of Nilotinib.

Application

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is an arylimidazole derivative. This compound includes multiple functional groups: aniline, methyl, and imidazole. Hence, the compound is readily available for further functionalization. This building block can typically synthesize homoleptic imidazole-type iridium (Ir) triplet emitters as a blue phosphorescent emitter in OLED. The iridium organometallic complex is formed by coordinating the imidazole and the aryl group to the iridium metal center. The trifluoromethyl group, with a strong electron-withdrawing effect, increases the energy gap between the highest occupied molecular orbital and the lowest unoccupied molecular orbital (HOMO-LUMO), hence enabling a blue shift in the photoluminescent emission[1].

References

[1] Qiang Wei. “Small-Molecule Emitters with High Quantum Efficiency: Mechanisms, Structures, and Applications in OLED Devices.” Advanced Optical Materials 6 20 (2018).

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline synthesis

822-36-6
54962-75-3
641571-11-1
Synthesis of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline from 4-Methylimidazole and 3-Amino-5-bromobenzotrifluoride

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Benzenamine, 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-, hydrochloride (1:1) Benzenamine, 3-iodo-5-(trifluoromethyl)- 3-(4-Methylimidazol-1-yl)-5-trifluoromethylbenzoic acid 3-Amino-5-bromobenzotrifluoride 1H-IMidazole, 4-Methyl-1-[3-nitro-5-(trifluoroMethyl)phenyl]-
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide 3-FLUORO-5-NITROBENZOTRIFLUORIDE 3-Amino-5-fluorobenzotrifluoride 4-Methylimidazole Benzotrifluoride

1of2

Preparation Products

3-Iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide Nilotinib

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Suppliers

Global( 346)Suppliers
Supplier Tel Email Country ProdList Advantage
Yangzhou Qinyuan Pharmatech Co.,ltd 		+86-18752526868 jennysun@yzqyyykj.com China 64 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7377 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
Anqing Chico Pharmaceutical Co., Ltd. 		15380796838 chloewu@chicopharm.cn CHINA 341 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 906 58
Supplier Advantage
Yangzhou Qinyuan Pharmatech Co.,ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
Anqing Chico Pharmaceutical Co., Ltd. 		58
career henan chemical co 		58
Shanghai Arbor Chemical Co., Ltd. 		58

View Lastest Price from 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline pictures 2024-03-29 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1
 US $35.00-1.20 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
3-(4-Methyl-1H-Imidazol-1-yl)-5-(Trifluoromethyl)Aniline pictures 2023-12-20 3-(4-Methyl-1H-Imidazol-1-yl)-5-(Trifluoromethyl)Aniline
641571-11-1
 US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline pictures 2023-03-12 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1
 US $0.00 / kg 1kg 98.0%min 100kg LY Global chemicals co.,ltd .

641571-11-1(3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline)Related Search:

Tris(hydroxymethyl)aminomethane Methyl acrylate Methylparaben METSULFURON METHYL ALTRENOGEST
3,3',5,5'-Tetramethylbenzidine dihydrochloride Acid Blue 93 o-Toluidine Bensulfuron methyl Aniline
Glycine N-Methylaniline N,N-Dimethyl-1,4-phenylenediamine Methyl cellulose 1-Methylimidazole
N,N-Dimethylaniline 3-Amino-5-bromobenzotrifluoride Nilotinib N-Oxide

1of4

Nilotinib genotoxic impurity 1 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Nilotinib Intemediate 1 1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl) benzene amine 3-(trifluoromethyl)-5-(4-methyl-1H-imidazol-1-yl)benzenamine 3-(4-Methyl-iMidazol-1-yl)-5-trifluoro-MethylphenylaMine 3-Amino-5-(4-methyl-1H-imidazol-1-yl)benzotrifluoride 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzeneaMine, 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)aniline BenzenaMine, 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)- 3-(4-Methyl-iMidazole-1-yl)-5-trifluoro MethylphenylaMine 5-(4-Methyl-1H-iMidazol-1-yl)-3-(trifluoroMethyl)-BenzeneaMine 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole Nilotinib Amino Impurity 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline > Nilotinib Related Compound A USP Impurity Certified Reference Standard 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoro methyl)benzamine 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl) 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline(For export only) 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline ISO 9001：2015 REACH 3-(4-Methyl-1-imidazolyl)-5-(trifluoromethyl)aniline Nilotinib EP Impurity A NILOTINIB IMPURITY 24 3-(4-Methyl-1H-imidazol-1-yl)-5- (trifluoromethyl)aniline(Nilotinib EP Impurity A) Nilotinib??Intermediates?A Nilotinib Hydrochloride Monohydrate Impurity A 5-(4-Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)benzenamine Nilotinib Impurity 15(Nilotinib EP Impurity A) 3-(4-Methyl-1H-Imidazol-1-yl)-5-(Tri?uoromethyl)Aniline 5-(4-Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-aniline 5- (4-methyl-1H-Imidazol-1-yl)3- (trifluoromethy benzenamine Nilotinib Hydrochloride Monohydrate EP Impurity A 641571-11-1 541571-11-1 Nilotinib/Tasigna Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals