ALPHA-(4-FLUOROPHENYL)-4-(5-FLUORO-2-PYRIMIDINYL)-1-PIPERAZINEBUTANOL HYDROCHLORIDE
- CAS No.
- 105565-55-7
- Chemical Name:
- ALPHA-(4-FLUOROPHENYL)-4-(5-FLUORO-2-PYRIMIDINYL)-1-PIPERAZINEBUTANOL HYDROCHLORIDE
- Synonyms
- BMS-181100;BMY-14802-1;BMY14802HyClHCl;BMY 14802 HYDROCHLORIDE;α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanolhydrochloride;ALPHA-(4-FLUOROPHENYL)-4-(5-FLUORO-2-PYRIMIDINYL)-1-PIPERAZINEBUTANOL HYDROCHLORIDE
- CBNumber:
- CB9152122
- Molecular Formula:
- C18H23ClF2N4O
- Molecular Weight:
- 384.85
- MDL Number:
- MFCD04039786
- MOL File:
- 105565-55-7.mol
| storage temp. | Desiccate at RT |
|---|---|
| solubility | <9.62mg/ml in H2O |
| form | solid |
| color | White |
| Water Solubility | Soluble to 25 mM in water |
| FDA UNII | 14F9C3J43Y |
ALPHA-(4-FLUOROPHENYL)-4-(5-FLUORO-2-PYRIMIDINYL)-1-PIPERAZINEBUTANOL HYDROCHLORIDE price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1440 | BMY14802hydrochloride ≥98%(HPLC) | 105565-55-7 | 10 | $128 | 2021-12-16 | Buy |
| Tocris | 1440 | BMY14802hydrochloride ≥98%(HPLC) | 105565-55-7 | 50 | $523 | 2021-12-16 | Buy |
| TRC | B596413 | BMY14802Hydrochloride | 105565-55-7 | 5mg | $305 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008914 | BMY 14802 HYDROCHLORIDE 95.00% | 105565-55-7 | 5MG | $505.95 | 2021-12-16 | Buy |
| ApexBio Technology | B5112 | BMY14802hydrochloride | 105565-55-7 | 10mg | $219 | 2021-12-16 | Buy |
ALPHA-(4-FLUOROPHENYL)-4-(5-FLUORO-2-PYRIMIDINYL)-1-PIPERAZINEBUTANOL HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
BMY 14802 Hydrochloride was studied to be a potential atypical antipsychotic agent.
Biological Activity
Potent sigma receptor antagonist (IC 50 = 112 nM) with modest to weak affinity for 5-HT 1A and α 1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.
in vitro
bmy 14802 has its most potent binding at the sigma binding site, with some degree of serotonin subtype 1a and negligible dopamine receptor binding [1].
in vivo
bmy 14802 is atypical of standard neuroleptics in that it does not induce catalepsy in rats. in addition, it has been shown to have efficacy in animal models of psychosis [1].
IC 50
112 nm for (+)-[3h]-3-ppp
References
[1] gewirtz gr, gorman jm, volavka j, macaluso j, gribkoff g, taylor dp, borison r. bmy 14802, a sigma receptor ligand for the treatment of schizophrenia. neuropsychopharmacology. 1994 feb;10(1):37-40.
ALPHA-(4-FLUOROPHENYL)-4-(5-FLUORO-2-PYRIMIDINYL)-1-PIPERAZINEBUTANOL HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ALPHA-(4-FLUOROPHENYL)-4-(5-FLUORO-2-PYRIMIDINYL)-1-PIPERAZINEBUTANOL HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3444 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9440 | 58 |
| Jingmo (Xiamen) Biotechnology Co., Ltd | 13621943973 13515979683 | sales@jamxmpharmatech.com | China | 1079 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | market@aladdin-e.com | China | 48617 | 58 |