BRL 44408 MALEATE
- CAS No.
- 118343-19-4
- Chemical Name:
- BRL 44408 MALEATE
- Synonyms
- BRL 44408;BRL 44408 MALEATE;BRL 44408 maleate salt;2-[2H-(1-METHYL-1,3-DIHYDROISOINDOLE)METHYL]-4,5-DIHYDROIMIDAZOLE MALEATE;2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole;2-[[(1-Methyl-1,3-dihydro-2H-isoindol)-2-yl]methyl]-4,5-dihydro-1H-imidazole;1H-Isoindole, 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-;2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt;2-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-2,3-DIHYDRO-1-METHYL-1H-ISOINDOLE MALEATE;2-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,3-dihydro-1-methyl-1H-isoindole BRL 44408
- CBNumber:
- CB9159570
- Molecular Formula:
- C13H17N3
- Molecular Weight:
- 215.29
- MDL Number:
- MFCD02262218
- MOL File:
- 118343-19-4.mol
| Boiling point | 365.8±30.0 °C(Predicted) |
|---|---|
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | H2O: ~26 mg/mL, soluble |
| form | solid |
| pka | 10.29±0.40(Predicted) |
| color | off-white |
| FDA UNII | ZET7B198W2 |
BRL 44408 MALEATE price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B4559 | BRL 44408 maleate salt ≥98% (HPLC) | 118343-19-4 | 10mg | $187 | 2024-03-01 | Buy |
| Sigma-Aldrich | B4559 | BRL 44408 maleate salt ≥98% (HPLC) | 118343-19-4 | 50mg | $789 | 2024-03-01 | Buy |
| Tocris | 1133 | BRL44408maleate ≥98%(HPLC) | 118343-19-4 | 10 | $173 | 2021-12-16 | Buy |
| Tocris | 1133 | BRL44408maleate ≥98%(HPLC) | 118343-19-4 | 50 | $724 | 2021-12-16 | Buy |
| TRC | B677680 | BRL44408 | 118343-19-4 | 100mg | $1175 | 2021-12-16 | Buy |
BRL 44408 MALEATE Chemical Properties,Uses,Production
Uses
Selective a2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration
Uses
BRL 44408 Maleate was used to study for norepinephrine reuptake modulators for preventing and treating vasomotor symptoms.
Uses
Selective α2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration.
Biological Activity
Selective α 2A -adrenoceptor antagonist (K i = 1.7 nM and 144.5 nM at α 2A and α 2B -adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α 2 -Adrenoceptor Tocriset™ .
Biochem/physiol Actions
BRL 44408 maleate is a selective α2A-adrenoceptor antagonist.
References
[1]. meana jj, callado lf, pazos a, et al. the subtype-selective alpha 2-adrenoceptor antagonists brl 44408 and arc 239 also recognize 5-ht1a receptors in the rat brain. eur j pharmacol, 1996, 312(3): 385-388.
[2]. owesson ca, seif i, mclaughlin dp, et al. different alpha(2) adrenoceptor subtypes control noradrenaline release and cell firing in the locus coeruleus of wildtype and monoamine oxidase-a knockout mice. eur j neurosci, 2003, 18(1): 34-42.
[3]. dwyer jm, platt bj, rizzo sj, et al. preclinical characterization of brl 44408: antidepressant- and analgesic-like activity through selective alpha2a-adrenoceptor antagonism. int j neuropsychopharmacol, 2010, 13(9): 1193-1205.
BRL 44408 MALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
BRL 44408 MALEATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18521732826; | market@aladdin-e.com | China | 25015 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |