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Trimethyl orthobenzoate

CAS No.
707-07-3
Chemical Name:
Trimethyl orthobenzoate
Synonyms
(Trimethoxymethyl)benzene;Methyl orthobenzoate;Benzene, (trimethoxymethyl)-;SKL283;NSC-67391;Orthobenzoate;trimethyl benzoate;TRIMETHYL-O-BENZOATE;Intedanib Impurity 6;Sunitinib Impurity 71
CBNumber:
CB9160297
Molecular Formula:
C10H14O3
Molecular Weight:
182.22
MDL Number:
MFCD00008474
MOL File:
707-07-3.mol
MSDS File:
SDS
Last updated:2024-03-13 16:52:01

Trimethyl orthobenzoate Properties

Boiling point 87-88 °C/7 mmHg (lit.)
Density 1.061 g/mL at 25 °C (lit.)
refractive index n20/D 1.489(lit.)
Flash point 180 °F
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in organic solvents.
form Liquid
color Clear colorless
Sensitive Moisture Sensitive
BRN 777623
Stability Hygroscopic
InChIKey IECKAVQTURBPON-UHFFFAOYSA-N
CAS DataBase Reference 707-07-3(CAS DataBase Reference)
FDA UNII 3755490344
NIST Chemistry Reference Benzene, (trimethoxymethyl)-(707-07-3)
EPA Substance Registry System Benzene, (trimethoxymethyl)- (707-07-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39-37/39
WGK Germany  3
TSCA  Yes
HS Code  29163100
NFPA 704
2
2 1

Trimethyl orthobenzoate price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 164534 Trimethyl orthobenzoate 98% 707-07-3 50g $486 2024-03-01 Buy
Sigma-Aldrich 164534 Trimethyl orthobenzoate 98% 707-07-3 10g $99.4 2023-06-20 Buy
TCI Chemical T2287 Trimethyl Orthobenzoate >95.0%(GC) 707-07-3 5g $18 2024-03-01 Buy
TCI Chemical T2287 Trimethyl Orthobenzoate >95.0%(GC) 707-07-3 25g $52 2024-03-01 Buy
Alfa Aesar A10270 Trimethyl orthobenzoate, 98% 707-07-3 10g $40.65 2024-03-01 Buy
Product number Packaging Price Buy
164534 50g $486 Buy
164534 10g $99.4 Buy
T2287 5g $18 Buy
T2287 25g $52 Buy
A10270 10g $40.65 Buy

Trimethyl orthobenzoate Chemical Properties,Uses,Production

Chemical Properties

clear colorless liquid

Uses

Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 1661, 1950 DOI: 10.1021/ja01160a067

General Description

Trimethyl orthobenzoate reacts with P-dimethylaminophosphonic acid bis(1-methylhydrazide) to yield 1,2,5,6-tetrahydro-1,5-dimethyl-6-(N,N-dimethylamino)-6-phenyl-1,2,4,5,6-tetrazaphosphorine-6-oxide.

100-47-0
55-21-0
707-07-3
Synthesis of Trimethyl orthobenzoate from Benzonitrile
Global( 281)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830 figo.gao@foxmail.com China 8136 58
Hong Kong Excellence Biotechnology Co., Ltd.
+86-86-18838029171 +8618126314766 ada@sh-teruiop.com China 892 58
Sigma Audley
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Shanghai Aosiris new Material Technology Co., LTD
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Capot Chemical Co.,Ltd.
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Henan Tianfu Chemical Co.,Ltd.
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ATK CHEMICAL COMPANY LIMITED
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Anqing Chico Pharmaceutical Co., Ltd.
15380796838 chloewu@chicopharm.cn CHINA 341 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58

View Lastest Price from Trimethyl orthobenzoate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trimethyl orthobenzoate pictures 2024-03-28 Trimethyl orthobenzoate
707-07-3
US $5.00 / kg 1kg ≥99% 211-897-5 Jinan Finer Chemical Co., Ltd
Trimethyl orthobenzoate pictures 2024-03-22 Trimethyl orthobenzoate
707-07-3
US $100.00 / kg 1kg 99.9% 20tons Hong Kong Excellence Biotechnology Co., Ltd.
Trimethyl orthobenzoate pictures 2024-03-13 Trimethyl orthobenzoate
707-07-3
US $3.00-1.00 / kg 1kg 99.9% 10 tons Shanghai Aosiris new Material Technology Co., LTD
(trimethoxymethyl)-benzen Orthobenzoic acid, trimethyl ester à,à,à-trimethoxytoluene Thrimethyl orthobenzoate Phenylorthoformic acid trimethyl ester Phenyltrimethoxymethane Trimethoxyphenylmethane Trimethyl orthobenzoate,97% alpha,alpha,alpha-Trimethoxytoluene Orthobenzoic Acid Trimethyl Ester alpha,alpha,alpha-Trimethoxytoluene Methyl Orthobenzoate Trimethyl orthobenzoate 98% TRIMETHYL ORTHOBENZOATE TRIMETHYL-O-BENZOATE TriMethyl Orthobenzoate, 95%(GC) Orthobenzoate NSC-67391 Intedanib Impurity 6 Trimethyl Orthobenzoate Liquid trimethyl benzoate SKL283 Trimethyl orthobenzoate (Nintedanib Impurity) (Trimethoxymethyl)benzene Benzene, (trimethoxymethyl)- Methyl orthobenzoate Sunitinib Impurity 71 707-07-3 C6H5COCH33 Building Blocks Oxygen Compounds Organic Building Blocks Acetals/Ketals/Ortho Esters Acetals/Ketals/Ortho Esters Organic Building Blocks Oxygen Compounds bc0001 707-07-3