PHLEOMYCIN
- CAS No.
- 11006-33-0
- Chemical Name:
- PHLEOMYCIN
- Synonyms
- CL990-cin;nsc616586;ZEOCIN(TM);PHLEOMYCIN;Zeocin powder;phleomycincomplex;PHLEOMYCIN USP/EP/BP;PHLEOMYCIN (STREPTOMYCES VERTICILLUS);hleoMycin froM streptoMyces verticillus;PHLEOMYCIN FROM STREPOMYCES VERTICILLUS,
- CBNumber:
- CB9166103
- Molecular Formula:
- C55H86N20O21S2
- Molecular Weight:
- 0
- MDL Number:
- MFCD30738212
- MOL File:
- Mol file
- MSDS File:
- SDS
| Boiling point | 527.46°C (rough estimate) |
|---|---|
| Density | 1.3193 (rough estimate) |
| refractive index | 1.5600 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: 10 mg/mL, clear, blue |
| form | powder |
| color | light blue |
| EWG's Food Scores | 1 |
| FDA UNII | BN3E7WJN9X |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SY0525000 | |||||||||
| F | 10 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29419059 | |||||||||
| Toxicity | dog,LD50,intravenous,2500ug/kg (2.5mg/kg),Toxicology and Applied Pharmacology. Vol. 14, Pg. 590, 1969. | |||||||||
| NFPA 704 |
|
PHLEOMYCIN price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P9564 | Phleomycin from Streptomyces verticillus powder | 11006-33-0 | 5mg | $106 | 2024-03-01 | Buy |
| Sigma-Aldrich | P9564 | Phleomycin from Streptomyces verticillus powder | 11006-33-0 | 25mg | $367 | 2024-03-01 | Buy |
| Alfa Aesar | J67027 | Phleomycin, 20 mg/ml in 5mM HEPES buffer, sterile-filtered | 11006-33-0 | 5x1ml | $430 | 2024-03-01 | Buy |
| Alfa Aesar | J67027 | Phleomycin, 20 mg/ml in 5mM HEPES buffer, sterile-filtered | 11006-33-0 | 1ml | $158 | 2023-06-20 | Buy |
| Cayman Chemical | 15549 | Phleomycin ≥95% | 11006-33-0 | 5mg | $62 | 2024-03-01 | Buy |
PHLEOMYCIN Chemical Properties,Uses,Production
Description
Phleomycin is a glycopeptide antibiotic from Streptomyces whose cytotoxic action results from its ability to cause DNA fragmentation. The ability of phleomycin to block mammalian cells from entering mitosis has made it useful in cancer therapy, most commonly in conjunction with other therapeutic modalities. Phleomycin is also used, in conjunction with a vector carrying the bleomycin resistance protein ble, as a selective agent in the transformation of yeast, plant cells, and mammalian cells.
Uses
Phleomycin is a metal-complexing DNA degrading antibiotic.
General Description
Phleomycin is a glycopeptide antibiotic and is a member of the bleomycin family.
Biochem/physiol Actions
Phleomycin can bind and intercalate with the DNA that leads to DNA strand breaks. It acts as an inhibitor of DNA replication.
in vitro
previous study found that the chromosomes could be cleaved into nucleosomes and degraded by phleomycin over significantly narrower dose ranges than by bleomycin. in addition, phleomycin also showed lower specificity for internucleosomal cleavage than bleomycin. moreover, it was found that the higher reactivity of phleomycin did not solely result from its higher rate of internucleosomal and intranucleosomal chromatin cleavage, since short phleomycin reactions always led to more extensive chromatin cleavage at low concentrations [1].
in vivo
a study of the in-vivo effects of phleomycin on meiosis of the mouse egg demonstrated a spectrum of damage to both first metaphase and second metaphase with polar body. the minimal effective dose in vivo of 2.5 μg/g of body weight could alter 28.3% of first metaphase figures and 50% of second metaphase cells [2].
References
[1] moore, c. w. internucleosomal cleavage and chromosomal degradation by bleomycin and phleomycin in yeast. cancer research 48(23), 6837-6843 (1988).
[2] jagiello gm. action of phleomycin on the meiosis of the mouse ovum. mutat res. 1968 sep-oct;6(2):289-95.
PHLEOMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
PHLEOMYCIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 | wendy@huidabiotech.com | CHINA | 87 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
View Lastest Price from PHLEOMYCIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-09 | PHLEOMYCIN
11006-33-0
|
US $8.00-0.80 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2021-07-17 | PHLEOMYCIN USP/EP/BP
11006-33-0
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-12-26 | PHLEOMYCIN
11006-33-0
|
US $1.00 / g | 1g | ≥98% | g/kg/Ton | Career Henan Chemical Co |
-
- PHLEOMYCIN
11006-33-0
- US $8.00-0.80 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- PHLEOMYCIN USP/EP/BP
11006-33-0
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- PHLEOMYCIN
11006-33-0
- US $1.00 / g
- ≥98%
- Career Henan Chemical Co
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