SINEFUNGIN
- CAS No.
- 58944-73-3
- Chemical Name:
- SINEFUNGIN
- Synonyms
- SF;A-9145;rp32232;32232RP;SINEFUNGIN;Sinefungine;SCF from rat;Steel Factor;compound57926;A 9145, RP 32232
- CBNumber:
- CB9167377
- Molecular Formula:
- C15H23N7O5
- Molecular Weight:
- 381.39
- MDL Number:
- MFCD00865623
- MOL File:
- 58944-73-3.mol
- MSDS File:
- SDS
| alpha | D25 -2.61° (c = 5 in water); D23 +12 ±2° (c = 0.227 in water) |
|---|---|
| Boiling point | 783.2±70.0 °C(Predicted) |
| Density | 1.91±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble |
| form | powder |
| pka | pKa (66% DMF): 2.9, 3.9, 8.9, 10.2(at 25℃) |
| color | white to yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. |
| FDA UNII | W2U467CIIL |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| RTECS | HE3140000 |
| HS Code | 29419090 |
| Toxicity | LD50 s.c. in mice: 185 mg/kg (Hamill, Hoehn, J. Antibiot.) |
SINEFUNGIN price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S8559 | Sinefungin 95% (HPLC), powder | 58944-73-3 | 10mg | $640 | 2024-03-01 | Buy |
| Sigma-Aldrich | SRP3251 | SCF from rat recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture | 58944-73-3 | 10μG | $339 | 2023-06-20 | Buy |
| Cayman Chemical | 13829 | Sinefungin ≥95% | 58944-73-3 | 500μg | $43 | 2022-04-27 | Buy |
| Cayman Chemical | 13829 | Sinefungin ≥95% | 58944-73-3 | 1mg | $77 | 2022-04-27 | Buy |
| Cayman Chemical | 13829 | Sinefungin ≥95% | 58944-73-3 | 5mg | $292 | 2022-04-27 | Buy |
SINEFUNGIN Chemical Properties,Uses,Production
Description
Sinefungin (58944-73-3) is a nucleoside S-adenosyl-1-methionine analog. Potent, competitive methyltransferase (protein, DNA, and RNA methyltransferases) inhibitor.1,2?IC50?< 1.0 and 2.5 μM for PRMT1 and SET7/9, respectively.3?Sinefungin binds with greater affinity to the adenine-specific DNA methyltransferase M.TaqI than S-adenosyl-L-homocysteine.4?Inhibits biofilm formation by?Streptococcus pneumoniae.5
Uses
Sinefungin is a natural nucleoside analog of S-adenosylmethionine and inhibits Streptococcus pneumoniae biofilm growth. Its derivatives can be used as inhibitors and structure probes for human protein lysine methyltransferase SETD2.
Uses
Sinefungin, a polar nucleoside antifungal active with broad biological activity, was isolated from a number of species of Streptomyces in the early 1970s. Sinefungin acts by inhibiting a wide range of methyltransferases, including the methylation of bases in DNA and RNA which alters cytosine deamination and gene expression. Sinefungin is widely used as a bioprobe to block methyltransferase-dependent pathways.
Definition
ChEBI: An adenosine that is the the delta-(5'-adenosyl) derivative of ornithine.
General Description
Chemical structure: nucleoside
Biochem/physiol Actions
Probable transcription factor. Plays a critical role in the control of immune response.
References
1) Barbes?et al. (1990),?Effects of sinefungin and S-adenosylhomocysteine on DNA and protein methyltransferases from Streptomyces and other bacteria;? FEMS Microbiol. Lett.,?57?239 2) Yebra?et al. (1991),?The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces;? J. Antibiot. (Tokyo),?44?1141 3) Cheng?et al. (2004),?Small molecule regulators of protein arginine methyltransferases;? J. Biol. Chem.,?279?23892 4) Schluckebier?et al. (1997), Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to adenine-specific DNA methyltransferase M. TaqI;? J. Mol. Biol., 265?56 5) Yadav?et al. (2014),?Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumonia biofilm growth;? Biomed. Res. Int.,?2014?156987
SINEFUNGIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10027 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| ANHUI WITOP BIOTECH CO., LTD | 58 |
| BOC Sciences | 58 |
| NewCan Biotech Limited | 58 |
| Nextpeptide Inc | 58 |
| Alfa Chemistry | 58 |
| InvivoChem | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | 58 |
| LEAPCHEM CO., LTD. | 58 |