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H-ALA-TYR-PRO-GLY-LYS-PHE-NH2

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 structure

CAS No.: 352017-71-1

Chemical Name:: H-ALA-TYR-PRO-GLY-LYS-PHE-NH2

Synonyms: AY-NH;AY-NH2;PAR4-AP;AYPGKF-NH2;AYPGKFAMIDE;PAR-4 aMide, Mouse;PAR-4 AGONIST AMIDE;Allantoin Impurity 3;ALA-TYR-PRO-GLY-LYS-PHE-NH2;PAR-4 Agonist Peptide, amide

CBNumber:: CB9174223

Molecular Formula:: C34H48N8O7

Molecular Weight:: 680.79

MDL Number:: MFCD06796234

MOL File:: 352017-71-1.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Properties

Boiling point	1143.1±65.0 °C(Predicted)
Density	1.285±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	Soluble in H2O
pka	9.84±0.15(Predicted)
form	solid
Water Solubility	Soluble in water

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	J66921	Selective Protease-Activated Receptor 4 (PAR4) Agonist	352017-71-1	1mg	$65.9	2023-06-20	Buy
Alfa Aesar	J66921	Selective Protease-Activated Receptor 4 (PAR4) Agonist	352017-71-1	5mg	$212	2021-12-16	Buy
Tocris	1487	AY-NH2	352017-71-1	1	$309	2021-12-16	Buy
TRC	A795103	AY-NH2	352017-71-1	1mg	$280	2021-12-16	Buy
Usbiological	254695	AY-NH2	352017-71-1	1mg	$573	2021-12-16	Buy

Product number	Packaging	Price	Buy
J66921	1mg	$65.9	Buy
J66921	5mg	$212	Buy
1487	1	$309	Buy
A795103	1mg	$280	Buy
254695	1mg	$573	Buy

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Chemical Properties,Uses,Production

Uses

AY-NH2 is used in the synthetic preparation of PAR4 agonist peptides towards PAR4 receptor activation.

Biological Activity

ay-nh2 is a selective agonist of par4 with ec50 value of 11 μm [1].protease-activated receptor-4 (par4) is a member of pars and plays an important role in mediating cellular effects of thrombin through acting g-proteins i, 12/13 (rho and ras activation) and q (calcium signaling) [2].ay-nh2 is a potent par4 agonist and has a higher (~10 fold) activity than gypgkf-nh2. using rat platelet aggregation assay, it was shown that ay-nh2 had highly platelet aggregation ability than gy-nh2 and gf-nh2 [1]. when tested with platelet-rich plasma harvested from wild-type c57bl6 mice, ay-nh2 treatment exhibited highly agonist activity on par4 while had no effect on other pars [3].in male wistar rats model of paw oedema, i.pl. injection of ay-nh2 markedly reduced the nociceptive score in response to both noxious and non-noxious mechanical stimuli, thus inhibiting carrageenan-induced mechanical hyperalgesia and allodynia [4].

storage

Store at -20°C

References

[1]. hollenberg, m.d., et al., proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. br j pharmacol, 2004. 143(4): p. 443-54.
[2]. yu, g., et al., increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer. plos one, 2015. 10(4): p. e0122678.
[3]. faruqi, t.r., et al., structure-function analysis of protease-activated receptor 4 tethered ligand peptides. determinants of specificity and utility in assays of receptor function. j biol chem, 2000. 275(26): p. 19728-34.
[4]. asfaha, s., et al., protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. br j pharmacol, 2007. 150(2): p. 176-85.

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Suppliers

Global( 83)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Shanghai Longyu Biotechnology Co., Ltd.	+8615821988213	info@longyupharma.com	China	2531	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Hangzhou Go Top Peptide Biotech	0571-88211921	sales1@gotopbio.com	CHINA	2609	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3582	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58

Supplier	Advantage
BOC Sciences	58
Shanghai Longyu Biotechnology Co., Ltd.	58
career henan chemical co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Hangzhou Go Top Peptide Biotech	58
Alfa Chemistry	58
Chengdu Youngshe Chemical Co., Ltd.	58
TargetMol Chemicals Inc.	58
Hebei Miaoyin Technology Co.,Ltd	58
Nanjing TGpeptide	58

View Lastest Price from H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-17	H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 352017-71-1	US $7.00 / KG	1KG	99%	100KG	Career Henan Chemical Co
	2020-02-17	H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 352017-71-1	US $7.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
352017-71-1
US $7.00 / KG
99%
Career Henan Chemical Co

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
352017-71-1
US $7.00 / KG
99%
Career Henan Chemical Co

352017-71-1(H-ALA-TYR-PRO-GLY-LYS-PHE-NH2)Related Search:

H-GLY-TYR-PRO-GLY-LYS-PHE-NH2 H-SER-LEU-ILE-GLY-ARG-LEU-OH H-GLY-TYR-PRO-GLY-GLN-VAL-OH PAR-4 (1-6) amide (human) H-SER-LEU-ILE-GLY-ARG-LEU-NH2

COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (HUMAN) VKGILS-NH2 COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (MOUSE) PROTEASE Thrombin

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT

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PROTEASE-ACTIVATED RECEPTOR-4 AGONIST AMIDE PAR-4 AGONIST AMIDE H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 AY-NH2 AYPGKFAMIDE AYPGKF-NH2 (ALA1)-COAGULATION FACTOR II RECEPTOR-LIKE 3 (1-6) AMIDE (MOUSE) (ALA1)-PROTEINASE ACTIVATED RECEPTOR 4 (1-6) AMIDE (MOUSE) (ALA1)-PAR-4 (1-6) AMIDE (MOUSE) (ALA1)-THROMBIN RECEPTOR-LIKE 3 (1-6) AMIDE (MOUSE) ALA-TYR-PRO-GLY-LYS-PHE-NH2 Proteinase activated receptor 4 amide, mouse AYPGKFaMide, (Ala1)-ThroMbin Receptor-Like 3 (1-6) aMide (Mouse), (Ala1)-Coagulation Factor II Receptor-Like 3 (1-6) aMide (Mouse), (Ala1)-Proteinase Activated Receptor 4 (1-6) aMide (Mouse) PAR-4 aMide, Mouse PAR4-AP AYPGKF-NH2 Selective Protease-Activated Receptor 4 (PAR4) Agonist Protease-Activated Receptor-4, PAR-4 Agonist, amide (Ala1)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt PAR-4 Agonist Peptide, amide (PAR-4-AP AY-NH2;PAR4-AP;PROTEINASE-ACTIVATED RECEPTOR 4 ACTIVATING PEPTIDE Proteinase-Activated Receptor 4 Activating Peptide (2S)-N-[2-[[(2S)-6-amino-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]-1-[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide PAR-4 Agonist Peptide, amide(2TFA) AY-NH PAR-4 Agonist Peptide, amide L-Phenylalaninamide, L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl- Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt >=98% (HPLC), solid 352017-71-1/1228078-65-6（TFA） Allantoin Impurity 3 (Ala?)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt (Ala1)-PAR-4 (1-6)) amide (mouse)|[Ala1]-Protease Activated Receptor-4 (1-6) amide, mouse AY-NH2 trifluoroacetate salt 352017-71-1 Immunomodulators and Antibiotics Immune Cell Signaling and Blood Immune System Regulation BioChemical Cell Biology Cell Signaling and Neuroscience peptide Peptide Receptors Proteinase-activated receptor (PAR)