BIS(4-HYDROXYCINNAMOYL)METHANE
- CAS No.
- 33171-05-0
- Chemical Name:
- BIS(4-HYDROXYCINNAMOYL)METHANE
- Synonyms
- BISDEMETHOXY CURCUMIN;CURCUMIN 3;Misdemeanour;Didemethoxycurcumin;BIS-DESMETHOXYCURCUMIN;DEMETHOXYCURCUMIN, BIS-;Bisdemethoxycurcumin(b);(E,E)-BisdeMethoxycurcuMin;Bisdemethoxycurcumin(BDMC);Bis(p-hydroxycinnamoyl)methane
- CBNumber:
- CB9180475
- Molecular Formula:
- C19H16O4
- Molecular Weight:
- 308.33
- MDL Number:
- MFCD03419284
- MOL File:
- 33171-05-0.mol
Melting point | 221-223 ºC |
---|---|
Boiling point | 551.3±45.0 °C(Predicted) |
Density | 1.285 |
storage temp. | 2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
pka | 8.50±0.46(Predicted) |
form | solid |
color | Orange to Dark Orange |
BRN | 3149384 |
Stability | Light Sensitive |
LogP | 3.155 (est) |
FDA UNII | 2EFO1BP34R |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 29145090 | |||||||||
NFPA 704 |
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BIS(4-HYDROXYCINNAMOYL)METHANE price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | B6938 | Bisdemethoxycurcumin ≥98% (HPLC), solid | 33171-05-0 | 5mg | $118 | 2024-03-01 | Buy |
Sigma-Aldrich | PHR3434 | Bisdesmethoxycurcumin certified reference material, pharmaceutical secondary standard | 33171-05-0 | 50MG | $222 | 2024-03-01 | Buy |
Sigma-Aldrich | 90594 | Bisdemethoxycurcumin analytical standard | 33171-05-0 | 10mg | $322 | 2024-03-01 | Buy |
Sigma-Aldrich | 1075305 | Bisdesmethoxycurcumin UnitedStatesPharmacopeia(USP)ReferenceStandard | 33171-05-0 | 30mg | $394 | 2024-03-01 | Buy |
Cayman Chemical | 10960 | Bisdemethoxycurcumin | 33171-05-0 | 10mg | $107 | 2024-03-01 | Buy |
BIS(4-HYDROXYCINNAMOYL)METHANE Chemical Properties,Uses,Production
Uses
Bisdemethoxycurcumin is one of the three major forms of curcuminoids found in the rhizomes of turmeric. Bisdemethoxycurcumin displays antioxidant, anti-inflammatory as well as chemotherapeutic activit y. Bisdemethoxycurcumin acts as an inhibitor of human pancreatic α-amylase, a target for type-2 diabetes .
Uses
Bisdemethoxycurcumin has been used:
- to test its inhibitory effect on cell cycle and mitochondrial function in gastric adenocarcinoma cells
- to test it neuroprotective role against lead (Pb) induced toxicity in dopaminergic and noradrenergic systems of Meriones shawi
- as a standard for calibration curve generation to quantify plasma curcuminoids using high-performance liquid chromatography-diode array detection (HPLC-DAD) and ultraviolet (UV)
Definition
ChEBI: Bisdemethoxycurcumin is a beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups. It has a role as a metabolite and an EC 3.2.1.1 (alpha-amylase) inhibitor. It is a beta-diketone, a polyphenol, an enone and a diarylheptanoid. It is functionally related to a 4-coumaric acid.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10.
BIS(4-HYDROXYCINNAMOYL)METHANE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 290 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from BIS(4-HYDROXYCINNAMOYL)METHANE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-22 | Bisdemethoxycurcumin (BDMC)
33171-05-0
|
US $0.00 / kg | 1kg | 99.8% | 1000 kg | BINBO BIOLOGICAL CO.,LTD | ||
2024-03-28 | Bisdemethoxycurcumin
33171-05-0
|
US $0.00 / kg | 25kg | 6.04% | Inquiry | PNP Biotech Co. Ltd | ||
2023-02-24 | Bisdemethoxycurcumin
33171-05-0
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
- Bisdemethoxycurcumin (BDMC)
33171-05-0
- US $0.00 / kg
- 99.8%
- BINBO BIOLOGICAL CO.,LTD
- Bisdemethoxycurcumin
33171-05-0
- US $0.00 / kg
- 6.04%
- PNP Biotech Co. Ltd
- Bisdemethoxycurcumin
33171-05-0
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.