Hycanthone
- CAS No.
- 3105-97-3
- Chemical Name:
- Hycanthone
- Synonyms
- ETRENOL;hycanthon;nsc-134434;Win 249-33;HYCANTHONE;Etrenol(mesylate);lucanthonemetabolite;1-(2-diethylaminoethylamino)-4-methylol-thioxanthen-9-one;1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one;1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-9h-thioxanthen-9-on
- CBNumber:
- CB9181533
- Molecular Formula:
- C20H24N2O2S
- Molecular Weight:
- 356.48
- MDL Number:
- MFCD00083383
- MOL File:
- 3105-97-3.mol
- MSDS File:
- SDS
| Melting point | 100.6-102.8° |
|---|---|
| Boiling point | 570.5±50.0 °C(Predicted) |
| Density | 1.1269 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO : 30 mg/mL (84.16 mM) |
| pka | pKa 3.40 (Uncertain) |
| FDA UNII | 2BXX5EVN2A |
| NCI Drug Dictionary | Etrenol |
| EPA Substance Registry System | Hycanthone (3105-97-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H332-H350-H312 |
| Precautionary statements | P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312 |
| Hazard Codes | T |
| Risk Statements | 45-46-20/21/22 |
| Safety Statements | 53-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | XO1590000 |
Hycanthone price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H674305 | Hycanthone | 3105-97-3 | 1mg | $185 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | MTB0000500 | HYCANTHONE 95.00% | 3105-97-3 | 5MG | $505 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573440 | Hycanthone >98% | 3105-97-3 | 100mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573440 | Hycanthone >98% | 3105-97-3 | 250mg | $1431.4 | 2021-12-16 | Buy |
| ChemScene | CS-4690 | Hycanthone 98.85% | 3105-97-3 | 10mg | $60 | 2021-12-16 | Buy |
Hycanthone Chemical Properties,Uses,Production
Uses
Antischistosomal.
Uses
Hycanthone is the active metabolite of the anthelmintic prodrug Lucanthone (L473700), which is used in the treatment of schistosomiasis.
Definition
ChEBI: A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.
General Description
Odorless canary yellow to yellow-orange crystalline powder. Bitter taste.
Air & Water Reactions
1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE may be sensitive to prolonged exposure to air and light. Highly soluble in water.
Reactivity Profile
1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE is very sensitive to acid. .
Fire Hazard
Flash point data for 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE are not available; however, 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE is probably combustible.
Safety Profile
Poison by subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion. Experimental teratogenic effects. Human mutation data reported. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Hycanthone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 6000 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12742 | 55 | |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 41438 | 60 |