Ambroxol | 18683-91-5

Ambroxol Properties

Melting point	233-234 C
Boiling point	468.6±45.0 °C(Predicted)
Density	1.5863 (rough estimate)
refractive index	1.6220 (estimate)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Soluble in Water.
form	solid
pka	15.12±0.40(Predicted)
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference	18683-91-5(CAS DataBase Reference)
FDA UNII	200168S0CL
ATC code	R05CB06
NIST Chemistry Reference	Ambroxol(18683-91-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H315-H302-H335
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501
Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38
Safety Statements	36-26
WGK Germany	3
RTECS	GV8423000
Toxicity	guinea pig,LD50,intraperitoneal,280mg/kg (280mg/kg),Medicamentos de Actualidad. Vol. 15, Pg. 523, 1979.

Ambroxol price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	19377	Ambroxol ≥98%	18683-91-5	25mg	$29	2021-12-16	Buy
Cayman Chemical	19377	Ambroxol ≥98%	18683-91-5	50mg	$49	2021-12-16	Buy
Cayman Chemical	19377	Ambroxol ≥98%	18683-91-5	100mg	$93	2021-12-16	Buy
TRC	A575990	Ambroxol	18683-91-5	50mg	$130	2021-12-16	Buy
Biosynth Carbosynth	FA64052	Ambroxol	18683-91-5	2g	$150	2021-12-16	Buy

Product number	Packaging	Price	Buy
19377	25mg	$29	Buy
19377	50mg	$49	Buy
19377	100mg	$93	Buy
A575990	50mg	$130	Buy
FA64052	2g	$150	Buy

Ambroxol Chemical Properties,Uses,Production

Description

Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in rat), and inhibits the release of inflammatory mediators from human leukocytes and mast cells (effective dose ~ 100 μM)

Originator

Mucosolvan,Thomae,W. Germany,1980

Uses

Ambroxol is a metabolite of Bromohexine. Ambroxol Hydrochloride is a bronchosecretolytic drug. Free base of Ambroxol Hydrochloride (A575900).

Uses

expectorant

Definition

ChEBI: Ambroxol is an aromatic amine.

Manufacturing Process

6.5 g of N-(trans-p-hydroxycyclohexyl)-(2-aminobenzyl)-amine were dissolved in a mixture of 80 cc of glacial acetic acid and 20 cc of water, and then 9.6 g of bromine were added dropwise at room temperature while stirring the solution. After all of the bromine had been added, the reaction mixture was stirred for two hours more and was then concentrated in a water aspirator vacuum. The residue was taken up in 2 N ammonia, the solution was extracted several times with chloroform, and the organic extract solutions were combined and evaporated. The residue, raw N-(trans-phydroxycyclohexyl)-( 2-amino-3,5-dibromobenzyl)-amine, was purified with chloroform and ethyl acetate over silica gel in a chromatographic column, the purified product was dissolved in a mixture of ethanol and ether, and the solution was acidified with concentrated hydrochloric acid. The precipitate formed thereby was collected and recrystallized from ethanol and ether, yielding N-(trans-p-hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)-amine hydrochloride, MP 233-234.5°C (decomposition).

Therapeutic Function

Expectorant

References

1) Teramoto et al. (1999), Effects of ambroxol on spontaneous or stimulated generation of reactive oxygen species by bronchoalveolar lavage cells harvested from patients with or without chronic obstructive pulmonary diseases; Pharmacology, 59 135 2) Nowak et al. (1995), Ambroxol inhibits doxorubicin-induced lipid peroxidation in heart of mice; Free Radic. Biol. Med., 19 659 3) Gibbs et al. (1999), Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells; Inflamm. Res., 48 86

Ambroxol Preparation Products And Raw materials

Raw materials

Methyl anthranilate trans-4-Aminocyclohexanol hydrochloride Octanoic hydrazide Sodium sulfate Ambroxol hydrochloride

2-Methoxyethanol METHANESULFONYL HYDRAZIDE Dibromo Sulfurous Acid Methanesulfonyl chloride

1,4-Dioxane Concentrated sulfuric acid Lithium Aluminum Hydride Tetrachloroethylene Acetic acid

Bromide 1,4-Dibromobenzene

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Preparation Products

Ambroxol Suppliers

Global( 212)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Shaanxi Dideu Medichem Co. Ltd	18192627656	1012@dideu.com	China	3657	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58

Supplier	Advantage
Henan Bao Enluo International TradeCo.，LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58

View Lastest Price from Ambroxol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-19	Ambroxol 18683-91-5	US $9.00-7.00 / kilograms	10kilograms	99%	100tons	Hebei Dangtong Import and export Co LTD
2024-03-31	Ambroxol 18683-91-5	US $40.00-20.00 / kg	1kg	99%	2000000	Shanghai Chinqesen Biotechnology Co., Ltd.
2023-07-11	Ambroxol 18683-91-5	US $50.00 / kg	1kg	99.99%	50000tons	Henan Bao Enluo International TradeCo.，LTD

Ambroxol
18683-91-5
US $9.00-7.00 / kilograms
99%
Hebei Dangtong Import and export Co LTD

Ambroxol
18683-91-5
US $40.00-20.00 / kg
99%
Shanghai Chinqesen Biotechnology Co., Ltd.

Ambroxol
18683-91-5
US $50.00 / kg
99.99%
Henan Bao Enluo International TradeCo.，LTD

18683-91-5(Ambroxol)Related Search:

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2-AMINO-3,5-DIBROMOBENZYL ALCOHOL Neltenexine RAC TRANS AMBROXOL-D5

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4-((2-amino-3,5-dibromobenzyl)amino)-(e)-cyclohexano 5-dibromophenyl)methyl)amino)-4-(((2-amino-trans-cyclohexano Cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)- (E)- Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, trans- n-(2-amino-3,4-dibromociclohexil)-trans-4-aminociclohexanol n-(2-amino-3,4-dibromocyclohexyl)-trans-4-aminocyclohexanol N-(trans-4-Hidroxiciclohexil)-(2-amino-3,5-dibromobencil)amina N-(trans-4-Hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)-amine N-(trans-p-Hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)amine NA-872 trans-4-((2-Amino-3,5-dibromobencil)amino)ciclohexanol 4-[(2-azanyl-3,5-dibromo-phenyl)methylamino]cyclohexan-1-ol trans-4-((2-amino-3,5-dibromobenzyl)amine)cyclohexanol trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol 2-amino-3,5-dibromo-n-(trans-4-hydroxycyclohexyl)benzylamine AMBROXOL 4-(2-AMINO-3,5-DIBROMO-BENZYLAMINO)-CYCLOHEXANOL Bronchopmnt Duramu．Cat Fluibron Lindoxyl Motosol Mucofar Mucosan Pect Solvolan Sufactal Surbronc (1α,4β)-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol trans-N-[2-Amino-3,5-dibromobenzyl]-4-hydroxycyclohexylamine 4-[[(2-Amino-3，5-dibromophenyl)methyl]amino]cyclohexanol Ambroxolum Ambroxol USP/EP/BP AmbroxolQ: What is Ambroxol Q: What is the CAS Number of Ambroxol Q: What is the storage condition of Ambroxol Q: What are the applications of Ambroxol ambroxol base 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexano1-ol Ambroxo AMBROXOL 60.0% PELLETS 18683-91-5 23858-92-4 C13H19Br2ClN2O C13H18Br2N2O C13H18Br2N2OxHCl Analytical Standards AM to AQ Analytical Chromatography Product Catalog Alphabetic API