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PD 166285

PD 166285 structure

CAS No.: 212391-63-4

Chemical Name:: PD 166285

Synonyms: PD 166285;PD 166285 dihydrochloride;PD0166285 dihydrochloride;PD 166285 ISO 9001：2015 REACH;PD 166285 - CAS 212391-63-4 - Calbiochem;6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimi;6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylaMino)ethoxy]phenyl]aMino]-8-Methylpyrido[2,3-d]pyriMidin-7(8H)-one;6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one,dihydrochloride;6-(2,6-Dichloro-phenyl)-2-[4-(2-diethylaMino-ethoxy)-phenylaMino]-8-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one hydrochloride;6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride

CBNumber:: CB91873310

Molecular Formula:: C26H29Cl4N5O2

Molecular Weight:: 585.37

MDL Number:: MFCD18086890

MOL File:: 212391-63-4.mol

Last updated:2023-06-30 15:45:59

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PD 166285 Properties

Melting point	239-242?C
storage temp.	Desiccate at RT
solubility	DMSO, Methanol
form	Pale yellow solid
color	Yellow
Stability	Hygroscopic

PD 166285 price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	513028	PD 166285 - CAS 212391-63-4 - Calbiochem A cell-permeable, orally bioavailable, ATP-competitive, broad-spectrum tyrosine kinase inhibitor that suppresses angiogenesis both in vitro and in vivo.	212391-63-4	5mg	$216	2024-03-01	Buy
Tocris	3785	PD166285dihydrochloride ≥99%(HPLC)	212391-63-4	1	$118	2021-12-16	Buy
Usbiological	019157	PD-166285	212391-63-4	5mg	$460	2021-12-16	Buy
Usbiological	286681	PD 166285	212391-63-4	2mg	$460	2021-12-16	Buy
TRC	P217500	PD-166285	212391-63-4	25mg	$565	2021-12-16	Buy

Product number	Packaging	Price	Buy
513028	5mg	$216	Buy
3785	1	$118	Buy
019157	5mg	$460	Buy
286681	2mg	$460	Buy
P217500	25mg	$565	Buy

PD 166285 Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

A broad-spectrum receptor tyrosine kinase (RTK) inhibitor which shows anti-angiogenic activity and anti-tumor efficacy in combination with photodynamic therapy (PDT).

General Description

A cell-permeable, orally bioavailable, ATP-competitive, broad-spectrum tyrosine kinase inhibitor (IC₅₀ against against c-Src, Wee1, FGFR-1, Myt1, EGFR, and PDGFRβ = 8.4, 24, 39.3, 72, 87.5 and 98.3 nM, respectively) that suppresses angiogenesis both in vitro (max inhibition dose at 100 nM in HUVEC microcapillary formation assays) and in vivo (max inhibition achieved via 5 mg/kg p.o. in murine Matrigel plug angiogenesis assays), while exhibiting much reduced potency against Chk1, MAPK, and PKC (IC₅₀ = 3.4, 5, and 22.7 μM, respectively) and little activity toward IRTK and Cdk4/D1 even at concentrations as high as 50 μM. Shown to effectively block PDGF-, EGF-, and bFGF-stimulated receptor phosphorylations (IC₅₀ = 6.5, 1600, and 97.3 nM, respectively) and other cellular responses in rat aortic smooth muscle cells. Inhibition of cellular Wee1 activity by 500 nM PD 166285 in combination with 50 ng/ml nocodazole (Cat. No. 487928) treatment is also reported to result in a blockage of radiation-induced Cdc2 phosphorylation on Tyr15 and Thr14 in 7 human cancer cells and specifically demonstrated to sensatize PA-1 cultures to radiation-induced cell death in a p53-dependent manner.

Biological Activity

Potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFR β ) (IC 50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G 2 checkpoint.

storage

Desiccate at RT

PD 166285 Preparation Products And Raw materials

Raw materials

Preparation Products

PD 166285 Suppliers

Global( 69)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9553	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29474	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
Hefei Hirisun Pharmatech Co., Ltd	58
LEAP CHEM CO., LTD.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58

View Lastest Price from PD 166285 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-17	PD 166285 212391-63-4	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2021-10-14	PD 166285 212391-63-4	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2019-12-27	PD 166285 212391-63-4	US $1.00 / KG	1KG	97%-99.9%	100kg	Career Henan Chemical Co

PD 166285
212391-63-4
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

PD 166285
212391-63-4
US $1.10 / g
99.00%
Dideu Industries Group Limited

PD 166285
212391-63-4
US $1.00 / KG
97%-99.9%
Career Henan Chemical Co

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6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride PD 166285 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-onedihydrochloride PD 166285 dihydrochloride 6-(2,6-Dichloro-phenyl)-2-[4-(2-diethylaMino-ethoxy)-phenylaMino]-8-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one hydrochloride 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimi 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylaMino)ethoxy]phenyl]aMino]-8-Methylpyrido[2,3-d]pyriMidin-7(8H)-one PD 166285 - CAS 212391-63-4 - Calbiochem 6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one,dihydrochloride Pyrido[2,3-d]pyrimidin-7(8H)-one,6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methyl-,hydrochloride(1:2) PD 166285 ISO 9001：2015 REACH PD0166285 dihydrochloride 212391-63-4 C26H27Cl2N5O22HCl C25H27Cl2N5O22HCl C26H29Cl4N5O2 Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators