ChemicalBook >> CAS DataBase List >>2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether
2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether
- CAS No.
- 652142-94-4
- Chemical Name:
- 2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether
- Synonyms
- STING Agonist 1a;2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether
- CBNumber:
- CB91902720
- Molecular Formula:
- C19H11Cl2N5O
- Molecular Weight:
- 396.22954
- MDL Number:
- MOL File:
- 652142-94-4.mol
Last updated:2024-07-02 08:55:41
2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether Chemical Properties,Uses,Production
Biological Activity
STING agonist 1a is an agonist of stimulator of interferon genes (STING).1 It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50 = 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .
References
1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screeningBioorg. Chem.100103958(2020)
2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether Preparation Products And Raw materials
Raw materials
Preparation Products
2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether Suppliers
Global( 7)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11976 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 16377 | 58 |
2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether
STING Agonist 1a
652142-94-4
C19H11Cl2N5O