(S)-3-Hydroxypyrrolidine
- CAS No.
- 100243-39-8
- Chemical Name:
- (S)-3-Hydroxypyrrolidine
- Synonyms
- (S)-PYRROLIDIN-3-OL;S-HP;(S)-3-PyrroL;(S)-3-PYRROLIDINOL;(+)-3-Pyrrolidinol;3-PYRROLIDINOL, (S);(3S)-3-Pyrrolidinol;(S)-Pyrrolidine-3-ol;(3S)-Pyrrolidin-3-ol;(3S)-Pyrrolidine-3-ol
- CBNumber:
- CB9195781
- Molecular Formula:
- C4H9NO
- Molecular Weight:
- 87.12
- MDL Number:
- MFCD00192426
- MOL File:
- 100243-39-8.mol
- MSDS File:
- SDS
| Melting point | 15°C |
|---|---|
| Boiling point | 108-110 °C (8 mmHg) |
| alpha | -6.5 º (c=3.5% in MeOH) |
| Density | 1.078 g/mL at 20 °C (lit.) |
| refractive index |
n |
| Flash point | >110°C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid After Melting |
| pka | 14.91±0.20(Predicted) |
| color | Clear light yellow to yellow |
| Specific Gravity | 1.078 |
| optical activity | [α]20/D 6.5±1.5°, c = 3.5% in methanol |
| Water Solubility | Fully miscible in water. |
| Sensitive | Air Sensitive & Hygroscopic |
| BRN | 4652606 |
| CAS DataBase Reference | 100243-39-8(CAS DataBase Reference) |
| FDA UNII | PP22TE6CNU |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-40 | |||||||||
| Safety Statements | 26-37/39-36-22 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-34 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
(S)-3-Hydroxypyrrolidine price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 56437 | (S)-3-Pyrrolidinol ≥97.0% (sum of enantiomers, GC) | 100243-39-8 | 5ml | $320.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 56437 | (S)-3-Pyrrolidinol ≥97.0% (sum of enantiomers, GC) | 100243-39-8 | 1ml | $220 | 2023-06-20 | Buy |
| TCI Chemical | P1667 | (S)-3-Pyrrolidinol >97.0%(GC)(T) | 100243-39-8 | 1g | $54 | 2024-03-01 | Buy |
| TCI Chemical | P1667 | (S)-3-Pyrrolidinol >97.0%(GC)(T) | 100243-39-8 | 5g | $149 | 2024-03-01 | Buy |
| Alfa Aesar | L19498 | (S)-(-)-3-Hydroxypyrrolidine, 99%, ee 99% | 100243-39-8 | 1g | $153.65 | 2024-03-01 | Buy |
(S)-3-Hydroxypyrrolidine Chemical Properties,Uses,Production
Description
(S)-3-Hydroxypyrrolidine is a chiral organic compound that serves as an important building block in the synthesis of various pharmaceuticals and natural products. It is a four-membered heterocyclic amino alcohol, featuring a hydroxyl group and a stereogenic center. The 'S' prefix indicates the configuration at the stereocenter, which is crucial for its reactivity and biological activity. This compound is notable for its role as an intermediate in the synthesis of drugs, particularly those targeting the central nervous system. The enantiomeric purity of (S)-3-Hydroxypyrrolidine is often critical, as the 'R' and 'S' enantiomers can exhibit different pharmacological properties.
Chemical Properties
clear light yellow to yellow liquid after melting
Uses
(S)-(-)-3-Hydroxypyrrolidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.
Purification Methods
The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]
(S)-3-Hydroxypyrrolidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SyncoZymes (Shanghai) Co., Ltd., | +86-021-68187180-811 +86-13681683526 | lchen@syncozymes.com | China | 188 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 | alice@jndxj.com | China | 309 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5601 | 58 |
View Lastest Price from (S)-3-Hydroxypyrrolidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-12-26 | (S)-3-Hydroxypyrrolidine
100243-39-8
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | |
 |
2023-12-20 | (S) 3-hydroxypyrrolidine
100243-39-8
|
US $0.00-0.00 / kg | 1kg | 99% | 50000kg | Hebei Kingfiner Technology Development Co. , Ltd. | |
 |
2023-09-19 | (S)-3-Hydroxypyrrolidine
100243-39-8
|
US $50.00 / kg | 1kg | 0.99 | 10000 | Hebei Yanxi Chemical Co., Ltd. |
-
- (S)-3-Hydroxypyrrolidine
100243-39-8
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
-
- (S) 3-hydroxypyrrolidine
100243-39-8
- US $0.00-0.00 / kg
- 99%
- Hebei Kingfiner Technology Development Co. , Ltd.
-
- (S)-3-Hydroxypyrrolidine
100243-39-8
- US $50.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.