2-Iodo-4-nitroanisole
- CAS No.
- 5399-03-1
- Chemical Name:
- 2-Iodo-4-nitroanisole
- Synonyms
- 2-Iodo-4-nitroanisol;2-Iodo-4-ntiroanisole;2-IODO-4-NITROANISOLE;2-iodo-4-nitrobenzyl ether;3-Iodo-4-methoxynitrobenzene;1-Iodo-2-Methoxy-5-nitrobenzene;2-IODO-1-METHOXY-4-NITROBENZENE;Benzene, 2-iodo-1-methoxy-4-nitro-;1,2-diaza-4-azanidacyclopenta-2,5-diene;3-Iodo-4-Methoxynitrobenzene[2-Iodo-4-nitroanisole]
- CBNumber:
- CB9199754
- Molecular Formula:
- C7H6INO3
- Molecular Weight:
- 279.03
- MDL Number:
- MFCD00024328
- MOL File:
- 5399-03-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-IODO-4-NITROANISOLE AldrichCPR | S362816 | 1 unit | $185 |
| 2-IODO-4-NITROANISOLE AldrichCPR | S362816 | 250MG | $179 |
| 2-Iodo-4-nitroanisole | I737190 | 1g | $45 |
| 2-Iodo-4-nitroanisole | I737190 | 10g | $75 |
| 2-Iodo-4-nitroanisole | X8330 | 25g | $77 |
| More product size | |||
| Melting point | 96-98°C |
|---|---|
| Boiling point | 343.3±27.0 °C(Predicted) |
| Density | 1.893±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| Appearance | Light brown to brown Solid |
| InChI | InChI=1S/C7H6INO3/c1-12-7-3-2-5(9(10)11)4-6(7)8/h2-4H,1H3 |
| InChIKey | KBQBNJHOTNIGDD-UHFFFAOYSA-N |
| SMILES | C1(OC)=CC=C([N+]([O-])=O)C=C1I |
| CAS DataBase Reference | 5399-03-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2909309090 |
2-Iodo-4-nitroanisole price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S362816 | 2-IODO-4-NITROANISOLE AldrichCPR | 5399-03-1 | 1 unit | $185 | 2025-07-31 | Buy |
| Sigma-Aldrich | S362816 | 2-IODO-4-NITROANISOLE AldrichCPR | 5399-03-1 | 250MG | $179 | 2024-03-01 | Buy |
| TRC | I737190 | 2-Iodo-4-nitroanisole | 5399-03-1 | 1g | $45 | 2021-12-16 | Buy |
| TRC | I737190 | 2-Iodo-4-nitroanisole | 5399-03-1 | 10g | $75 | 2021-12-16 | Buy |
| AK Scientific | X8330 | 2-Iodo-4-nitroanisole | 5399-03-1 | 25g | $77 | 2021-12-16 | Buy |
2-Iodo-4-nitroanisole Chemical Properties,Uses,Production
Uses
2-Iodo-4-nitroanisole is commonly used in organic synthesis, especially as a synthetic intermediate in the fields of medicine and chemical research.
Synthesis
99-59-2
5399-03-1
Step A. Synthesis of 2-iodo-1-methoxy-4-nitrobenzene 2-Methoxy-5-nitroaniline (10.0 g, 0.060 mol) was suspended in water (150 mL) and concentrated sulfuric acid (12 mL, 0.22 mol) was added slowly. The temperature of the reaction mixture was maintained below 5 °C under cooling in an ice-salt bath, and a solution of sodium nitrite (4.8 g, 0.070 mol) in water (40 mL) was added dropwise. Subsequently, potassium iodide (16.8 g, 0.101 mol) was added and the mixture was heated to 90 °C and kept for 1 hour. Upon completion of the reaction, it was cooled to 0 °C and deep red crystals were precipitated, which were filtered, washed with water and dried. Purification by silica gel column chromatography (eluent: ethyl acetate/hexane) afforded the target compound 2-iodo-1-methoxy-4-nitrobenzene (13.6 g, 75% yield). 1H NMR (300 MHz, DMSO-d6): δ 8.57 (s, 1H), 8.28 (d, 1H), 7.19 (d, 1H), 3.98 (s, 3H). LCMS (M + H)+: m/z = 280.1 (C7H7INO3).
References
[1] Canadian Journal of Chemistry, 2005, vol. 83, # 3, p. 213 - 219
[2] Patent: US2009/286778, 2009, A1. Location in patent: Page/Page column 79
[3] Chem. News J. Ind. Sci., 1901, vol. 83, p. 285
[4] Journal of the Chemical Society, 1901, vol. 79, p. 1076,1077
[5] P. Ch. S., p. 238
2-Iodo-4-nitroanisole Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16514 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 2-Iodo-4-nitroanisole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-13 | 2-Iodo-1-methoxy-4-nitrobenzene
5399-03-1
|
US $2.00-5.00 / KG | 0.1KG | 99% | g-kg-tons | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- 2-Iodo-1-methoxy-4-nitrobenzene
5399-03-1
- US $2.00-5.00 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
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