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5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE structure

CAS No.: 51516-67-7

Chemical Name:: 5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE

Synonyms: BUTTPARK 87\09-40;5-Amino-1-(4-chlorophenyl);5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-&;5-aMino-1-(4-chlorophenyl)-1H-pyrazole-4-;5-AMINO-4-CYANO-1-(4-CHLOROPHENYL)PYRAZOLE;5-AMINO-1-(4-CHLOROPHENYL)-4-CYANOPYRAZOLE;5-amino-1 -(4-chlorophenyl) -4-cyano-1H-pyrazole;5-Amino-1-(4-chlorophenyl)pyrazole-4-carbonitrile;5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE;1H-Pyrazole-4-carbonitrile, 5-amino-1-(4-chlorophenyl)-

CBNumber:: CB9203976

Molecular Formula:: C10H7ClN4

Molecular Weight:: 218.64

MDL Number:: MFCD00052031

MOL File:: 51516-67-7.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:46

Request For Quotation

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE Properties

Melting point	169-173 °C
Boiling point	424.2±40.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	-1.15±0.10(Predicted)
form	solid
Appearance	Light brown to yellow Solid
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

Hazard Codes

Risk Statements

22-37/38-41-36/37/38-20/21/22

Safety Statements

26-36/39-36/37/39-22

RIDADR

UN3439

WGK Germany

HazardClass

6.1

PackingGroup

III

HS Code

29331990

NFPA 704

	0
2		0

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	659398	5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile 97%	51516-67-7	1g	$62	2023-06-20	Buy
Sigma-Aldrich	659398	5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile 97%	51516-67-7	5g	$204	2023-06-20	Buy
Alfa Aesar	H27358	5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile, 97%	51516-67-7	1g	$45.3	2021-12-16	Buy
Alfa Aesar	H27358	5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile, 97%	51516-67-7	5g	$146	2021-12-16	Buy
American Custom Chemicals Corporation	COR0003269	5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE 95.00%	51516-67-7	5G	$1661.47	2021-12-16	Buy

Product number	Packaging	Price	Buy
659398	1g	$62	Buy
659398	5g	$204	Buy
H27358	1g	$45.3	Buy
H27358	5g	$146	Buy
COR0003269	5G	$1661.47	Buy

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE Chemical Properties,Uses,Production

Chemical Properties

White to off-white crystalline powder

Synthesis

1073-69-4

123-06-8

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE

51516-67-7

GENERAL METHOD: 4-Chlorophenylhydrazine (0.001 mol) was mixed with 10 mL of ethanol, stirred and heated to reflux. Subsequently, ethoxymethylene malononitrile (0.001 mol) dissolved in 10 mL of ethanol was added slowly and dropwise. The reaction mixture was kept at reflux for 2 hours. After completion of the reaction, the mixture was poured into 50 mL of ice water. The precipitate precipitated was collected by filtration and washed with cold water to afford 5-amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile in 61-80% yield.

References

[1] Heterocyclic Communications, 2005, vol. 11, # 5, p. 385 - 388
[2] Medicinal Chemistry Research, 2018, vol. 27, # 8, p. 1876 - 1884
[3] European Journal of Medicinal Chemistry, 2008, vol. 43, # 4, p. 771 - 780
[4] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2892 - 2898
[5] Australian Journal of Chemistry, 1989, vol. 42, # 5, p. 747 - 750

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE Preparation Products And Raw materials

Raw materials

Malononitrile Triethyl orthoformate Stannous chloride Sodium nitrite Hydrochloric acid

4-Chloroaniline 4-Chlorophenylhydrazine Ethoxymethylenemalononitrile

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Preparation Products

5-Amino-1-(4-chloro-phenyl)-1H-pyrazole-4-carboxylic acid amide

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE Suppliers

Global( 75)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49733	58
Jinan Honest Pharm Co., Ltd	+8615318812076	zpy8217@163.com	China	286	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8829	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Hunan Jibang Biological Technology Co., LTD	+8613776644403	sales02@kingboomtech.com	China	1804	58
PT CHEM GROUP LIMITED	+86-85511178;	peter68@ptchemgroup.com	China	35425	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49983	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.	+8618950047208	ellena@amitychem.com	China	43416	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
Jinan Honest Pharm Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hunan Jibang Biological Technology Co., LTD	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58
Aladdin Scientific	58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.	58
Amadis Chemical Company Limited	58

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE Spectrum

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE(51516-67-7)¹HNMR

51516-67-7(5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE)Related Search:

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5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-& 5-Amino-1-(4-chlorophenyl)pyrazole-4-carbonitrile 5-AMINO-1-(4-CHLOROPHENYL)-4-CYANOPYRAZOLE 5-AMINO-4-CYANO-1-(4-CHLOROPHENYL)PYRAZOLE 5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE BUTTPARK 87\09-40 5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile ,97% 5-Amino-1-(4-chlorophenyl) 5-aMino-1-(4-chlorophenyl)-1H-pyrazole-4- 1H-Pyrazole-4-carbonitrile, 5-amino-1-(4-chlorophenyl)- 5-amino-1 -(4-chlorophenyl) -4-cyano-1H-pyrazole 5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile 51516-67-7 Heterocyclic Building Blocks Halogenated Heterocycles Pyrazoles Building Blocks Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrazoles PyrazolesHeterocyclic Building Blocks