ANTI-CONNEXIN-32 (106-124)

Uses

Anti-Connexin-32 (106-124) antibody produced in rabbit has been used in:

• western blotting
• immunofluorescence
• immunohistology

General Description

Connexins (Cx) are a multi-gene family of highly related proteins with molecular weights ranging from 26 to 70 kDa. The structure of connexin molecules includes a cytoplasmic N-terminal region, four transmembrane domains, two extracellular loops, and a C-terminal cytoplasmic tail of varying length. The 27kD connexin protein (connexin 32, Cx32) is expressed in several tissues.

Biochem/physiol Actions

Cx32 mutations is associated with X-linked Charcot-Marie-Tooth (CMTX) disease, which leads to myelin disruption and axonal degeneration.