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Adenosine 5'-monophosphate

Chemical Properties Applications Preparation Usage restriction Category Toxicity Grading Acute Toxicity Flammability Hazardous Characteristics Storage and Transport Extinguishing Agent
Adenosine 5'-monophosphate
Adenosine 5'-monophosphate
CAS No.
61-19-8
Chemical Name:
Adenosine 5'-monophosphate
Synonyms
AMP;a5mp;adenyl;AMP.H2;lycedan;myoston;my-b-den;phosaden;Ado-5'-P;adenovite
CBNumber:
CB9206528
Molecular Formula:
C10H14N5O7P
Formula Weight:
347.22
MOL File:
61-19-8.mol

Adenosine 5'-monophosphate Properties

Melting point:
178-185 °C
storage temp. 
−20°C
solubility 
H2O: with addition of mild alkalisoluble
form 
Crystalline Powder
pka
3.8, 6.2(at 25℃)
color 
Colorless to white
Water Solubility 
Soluble in water.
Merck 
14,158
CAS DataBase Reference
61-19-8(CAS DataBase Reference)
EPA Substance Registry System
5'-Adenylic acid(61-19-8)

SAFETY

Safety Statements  24/25
WGK Germany  3
RTECS  AU7480500
TSCA  Yes
Hazardous Substances Data 61-19-8(Hazardous Substances Data)

Adenosine 5'-monophosphate price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1012178 5′-Adenylic acid 61-19-8 500mg $340.55 2018-11-20 Buy
TCI Chemical A0158 5'-Adenylic Acid >98.0%(HPLC)(T) 61-19-8 1g $13 2018-11-22 Buy
TCI Chemical A0158 5'-Adenylic Acid >98.0%(HPLC)(T) 61-19-8 5g $36 2018-11-22 Buy
Alfa Aesar L14051 Adenosine-5'-monophosphoric acid, 99% (dry wt.), water <6% 61-19-8 5g $55.1 2018-11-13 Buy
Alfa Aesar L14051 Adenosine-5'-monophosphoric acid, 99% (dry wt.), water <6% 61-19-8 1g $19.8 2018-11-13 Buy

Adenosine 5'-monophosphate Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder. Melting point: 196-200°C (decomposition). Specific optical rotation:-47.5° (20°C, 2% in sodium hydroxide (2%)). Soluble in water, slightly soluble in alcohol, insoluble in ether.

Applications

Clinically it is used to treat disseminated sclerosis, porphyria, itching, liver disease, varicose ulcer complication. Eye drops with denosine monophosphate as the main component can be used to treat eye fatigue, central amphiblestitis, ocular pannus,  herpes and other corneal surface diseases. Intramuscular injection shows local erythema, generalized essential telangiectasia, red face, dizziness, breathing difficulty and palpitation.
As nutrition enhancer; as intermediate to produce nucleotide drugs; as food additive; as biological products; as dietary supplement and biochemical reagent. It is used to produce adenosine triphosphate (ATP), cyclic adenylate (cAMP) and other biochemical drugs. It is a type of nucleotide products and to produce antiviral drugs, synthetic energy drugs and cardiovascular and cerebrovascular drugs, such as adenosine, ATP, 3 '-5'-cyclic adenosine monophosphate.

Preparation

Candida utilis fungi is treated with hot water to obtain nucleic acids, which is hydrolyzed by enzymes and separated to obtain the final product.
Take mycelia as the raw material:
Subtraction and sedimentation of mycelia are carried out with 3 times amount of water. Industry base is added to reach a base concentration of 0.25% (g/100mL). After stirring for 1 hours, 20% sulfuric acid is added until the PH value is 7. The solution is filtrated and the pH value of filtrate is adjusted with 20% sulfuric acid to 2.5. Centrifugation is then applied to obtain nucleic acid mud.
mycelia [sodium hydroxide]→[1h] extract solution [20% sulfuric acid] → [pH=7, filtration] filtrate [20% sulfuric acid] →[pH=2.5, centrifugation] nucleic acid mud
1% nucleic acid solution is made by subsequent dissolution, enzymolysis, absorption and elution. 10% ammonia water is then used to adjust the pH value to 6-6.2. Then the mixture is heated at 90°C for 20 min and cooled. After centrifugation, the supernatant is heated up to 65-70°C and added with 1/3 phosphodiesterase solution. After 2 hours, the temperature is raised to 90°C.  10min later, it is cooled to room temperature. 20% sulfuric acid is added to adjust the pH value to 2.5-3. After filtration, the filtrate is adjusted with ammonia solution until the pH=7.2-7.5. 0.3% (3 g/L) diatomite is then added to assist the filtration. The corresponding supernatant is filtered with an anion exchange resin column (717-type) and eluted with 0.05 mol/L sulfuric acid. Afterwards, absorption, elution and crystallization are carried out. The detailed procedures of these three steps are:
The eluate is first absorbed with a cation exchange column (732-type) and eluted with distilled water (pH=1.5). The collection of eluate starts when the eluate turned red with bromine water. The eluate is then concentrated to 80-90 mg/mL under reduced pressure, added with diatomite and stirred for 30 min before filtration. The filtrate is adjusted with 6 mol/L hydrochloric acid till pH=2.5. To realize full crystallization, the filtrate is cooled during stirring. After followed filtration, it is washed with dry ethanol for 3 times. Vacuum drying at 60°C is applied to obtain the final AMP products.
Nucleic acid mud [ammonia gas] →[pH=6-6.2, 90°C, 20min] supernatant [phosphodiesterase] →[65-70°C,2h,] hydrolysis solution [717 resin] →absorbent [sulfuric acid] →elution solution [732 resin] →AMP, CMP, GMP absorbent mixtures.

Usage restriction

GB 2760-2001:infant formula milk powder 0.2~0.58 g/kg (based on the total amount of nucleotide)

Category

Toxic substance

Toxicity Grading

Middle toxicity

Acute Toxicity

Peritoneal-mouse LD50: 4000 mg/kg

Flammability Hazardous Characteristics

Flammable; generation of toxic nitrogen oxides and phosphorous oxide smoke when heated.

Storage and Transport

Stored in well ventilated area, low temperature, and dry.

Extinguishing Agent

Dry powder, foam, sand, carbon dioxide.

Chemical Properties

colorless to white crystalline powder

Uses

antiasthmatic

Uses

vasodilator, neuromodulator

Uses

Adenosine 5'-Monophosphate is a natural occurring nucleotide and a useful ligand determinant that facilitate the binding of APS reductase inhibitors and activates adenosine receptor agonists.

Uses

A useful ligand determinant that facilitates the binding of APS reductase inhibitors.

Definition

ChEBI: A purine ribonucleoside 5'-monophosphate having adenine as the nucleobase.

brand name

Adenyl (Wyeth-Ayerst); My-BDen (Bayer.

Adenosine 5'-monophosphate Preparation Products And Raw materials

Raw materials

Preparation Products


Adenosine 5'-monophosphate Suppliers

Global( 299)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19957 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22080 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1523 55
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 300 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 10010 58
Taizhou Ruixin Chemical Co., Ltd. 15867635987 ;0576-89085261
0576-89085262 sales@runsunchemical.com; jasonhu09@163.com China 292 50

View Lastest Price from Adenosine 5'-monophosphate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-02 Adenosine 5'-monophosphate
61-19-8
US $100.00 / KG 1KG 99% Customized

Adenosine 5'-monophosphate Spectrum


61-19-8(Adenosine 5'-monophosphate)Related Search:


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  • Adenosine 5'-monophosphate;Adenosine-5'-monophosphoric acid;Adenosinephosphate;5'-Adenylic acid;t-Adenylic acid;AMP;5'-AMP;A-5'-MP;A-5'-P;Ergadenylic acid;Lycedan;Muscle adenylic acid;Myoston;NSC-20264
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  • Adenosin-5'-Monophosphate
  • ADENOSINE PHOSPHATE(VITAMIN B8)
  • Adenosine Monophosphate (Amp)
  • 5'-AMP=5'-Adenylicacid
  • C10H14N5O7P
  • 5'-ADENOSINE MONOPHOSPHORIC ACID
  • ADENOSINE MONOPHOPHATE, CYCLIC
  • ADENOSINE 5'-MONOPHOSPHATE, FREE ACID (5'-AMP)
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  • 5''-ADENYLIC ACID: ADENOSINE-5''-MONOPHOSPHORIC ACID : AMP
  • Pharmaceutical Intermediates
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  • Organic acids
  • Heterocyclic Compounds
  • Biochemistry
  • Nucleosides, Nucleotides & Related Reagents
  • Nucleotides and their analogs
  • Adenosine-5-Monophosphate(AMP)
  • Nucleic acids
  • Adenosine 5'-(dihydrogen phosphate)
  • Ado-5'-P
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