Nebivolol
- CAS No.
- 118457-14-0
- Chemical Name:
- Nebivolol
- Synonyms
- R065824;Nobiten;Vasoxen;R-065824;R 065824;NEBIVOLOL;dl-Nebivolol;L-Nebivolo1 D4;Unii-030Y90569u;Nebivolol USP/EP/BP
- CBNumber:
- CB92131013
- Molecular Formula:
- C22H25F2NO4
- Molecular Weight:
- 405.43
- MDL Number:
- MOL File:
- 118457-14-0.mol
| Melting point | 155-156°C |
|---|---|
| Boiling point | 600.5±55.0 °C(Predicted) |
| Density | 1.309 |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | pKa 8.22(H2O,t =25±1,Iundefined,Ar) (Uncertain) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | 030Y90569U |
| ATC code | C07AB12 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
Nebivolol price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 460622 | Nebivolol | 118457-14-0 | 10mg | $460 | 2021-12-16 | Buy |
| Usbiological | 460623 | Nebivolol | 118457-14-0 | 500ug | $566 | 2021-12-16 | Buy |
| AHH | API-1568 | Nebivolol 98% | 118457-14-0 | 1g | $760 | 2021-12-16 | Buy |
| Crysdot | CD31004384 | Nebivolol 98+% | 118457-14-0 | 50mg | $773 | 2021-12-16 | Buy |
| Crysdot | CD31004384 | Nebivolol 98+% | 118457-14-0 | 5mg | $180 | 2021-12-16 | Buy |
Nebivolol Chemical Properties,Uses,Production
Uses
Antihypertensive (β-blocker).
Uses
Nebivolol is a cardioselective beta-1 receptor blocking agent.
Definition
ChEBI: (R,S,S,S)-nebivolol is a 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] that has (1S,1'S,2R,2'S)-configuration. It is a conjugate base of a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol.
Clinical Use
Beta-adrenoceptor blocker:
Essential hypertension
Adjunct in heart failure
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: NSAIDs antagonise hypotensive effect.
Anti-arrhythmics: increased risk of myocardial
depression and bradycardia; increased risk of
bradycardia, myocardial depression and AV block
with amiodarone; increased risk of myocardial
depression and bradycardia with flecainide.
Antidepressants: enhanced hypotensive effect with
MAOIs.
Antihypertensives; enhanced hypotensive effect;
increased risk of withdrawal hypertension with
clonidine; increased risk of first dose hypotensive effect
with post-synaptic alpha-blockers such as prazosin.
Antimalarials: increased risk of bradycardia with
mefloquine.
Antipsychotics enhanced hypotensive effect with
phenothiazines.
Calcium-channel blockers: increased risk of
bradycardia and AV block with diltiazem;
hypotension and heart failure possible with
nifedipine and nisoldipine; asystole, severe
hypotension and heart failure with verapamil.
Cytotoxics: possible increased risk of bradycardia
with crizotinib.
Diuretics: enhanced hypotensive effect.
Fingolimod: possibly increased risk of bradycardia.
Moxisylyte: possible severe postural hypotension.
Sympathomimetics: severe hypertension with
adrenaline and noradrenaline and possibly with
dobutamine.
Metabolism
Nebivolol is extensively metabolised in the liver by acyclic and aromatic hydroxylation, N-dealkylation, and glucuronidation. Hydroxylation is by cytochrome P450 isoenzyme CYP2D6, partly to active hydroxy-metabolites. It is excreted in the urine and faeces, almost entirely as metabolites.
Nebivolol Preparation Products And Raw materials
Raw materials
Preparation Products
Nebivolol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2255 | 58 |
| Shijiazhuang Gantuo Biotechnology Co., Ltd | +8613373514458 | gantuo02@cngantuo.com | China | 218 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from Nebivolol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-06-26 | Nebivolol
118457-14-0
|
US $200.00 / kg | 1kg | 99% | 1000kg/Month | Hebei Mingeng Biotechnology Co., Ltd | |
 |
2023-04-11 | Nebivolol
118457-14-0
|
US $100.00 / g | 10g | 99% | 1000g | Shijiazhuang Gantuo Biotechnology Co., Ltd | |
 |
2020-05-17 | Nebivolol
118457-14-0
|
US $0.00 / g | 1g | ≥95% | 1kg | BOC Sciences |