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Melanotan II

Description Historical Development Uses Controversy
Melanotan II
Melanotan II structure
CAS No.
121062-08-6
Chemical Name:
Melanotan II
Synonyms
MT2;MTII;MT-Ⅱ;Melanotan 2;Melanotan Ц;MalanotanIi;Melanotan ②;MELANOTAN II;mt2 receptor;Mt-Ii(Melanotan)
CBNumber:
CB9213757
Molecular Formula:
C50H69N15O9
Formula Weight:
1024.18
MOL File:
121062-08-6.mol

Melanotan II Properties

Density 
1.43
RTECS 
OL4225000
storage temp. 
−20°C
solubility 
H2O: 5 mg/mL, soluble
form 
solid
color 
white
InChIKey
JDKLPDJLXHXHNV-MFVUMRCOSA-N
CAS DataBase Reference
121062-08-6(CAS DataBase Reference)

SAFETY

Hazard Codes  Xn
Risk Statements  22
WGK Germany  3

Melanotan II price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M8693 Melanotan II acetate salt ≥95% (HPLC) 121062-08-6 1mg $165 2018-11-13 Buy
Alfa Aesar J65115 Melanotan II 121062-08-6 1mg $348 2018-11-13 Buy

Melanotan II Chemical Properties,Uses,Production

Description

Melanotan II is a synthetic analogue of the melanocortin peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that occurs naturally. In usage, Melanotan II has been revealed to have aphrodisiac and melanogenesis (tanning) effects that have been subjected to clinical trials and preliminary studies. The compound is a cyclic lactam analogue of α-MSH that has an amino sequence named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2). Notably, no government drug regulatory agency across the world had approved for the use of any compound incorporating the Melanotan II peptide by 2010

Historical Development

Melanotan II was first developed at the University of Arizona. Various studies conducted at the institution confirmed that the best defence against skin cancer was melanin activated in the skin, a tan. The researchers assumed that an effective procedure to reduce the rates of skin cancer in individuals would be by inducing the body’s natural pigmentary system to produce a tan that would be protective before exposure to UV. Melanogenesis is a process by which the skin’s pigment cells (melanocytes) produce the hormone α-MSH naturally causes the skin's pigment (melanin).
After numerous clinical trials by administration of the endogenous hormone to the body, the scientists found that though it appeared to work, α-MSH had a very short half-life in the body to be practical as a therapeutic drug. Therefore, they opted to look for a more stable and potent alternative that would be more practical. Subsequently, after numerous trials, they developed Melanotan I and after that Melanotan II.

Uses

Malanotan II is used for tanning of the skin and producing of erections in men with erectile dysfunction when administered as a shot under the skin. Malanotan II is safe when used under strict medical supervision for treating erectile dysfunction. However, it may cause stomach cramps, tiredness, nausea, spontaneous erections of the penis, and darkened skin.

Controversy

Melanotan II is widely sold online and in beauty salons as well as gyms as melanotan in their marketing. These products purport to contain the same chemical composition as afamelanotide. These products have been declared illegal and do not have the same chemical components as Melanotan II. As such, countries issues warnings against their use.

Clinical Use

Melanotan II has been a new treatment for rosacea discussed in the various rosacea support groups on the internet.
Melanotan I and Melanotan II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (a-MSH) that tend to induce skin tanning. Melanotan II has the additional effect of increasing libido.
Melanotan II is an α-MSH analog which underwent clinical trials for the treatment of erectile dysfunction. Preliminary double-blind, placebo-controlled studies demonstrated the efficacy of melanotan in inducing penile erection in men with erectile dysfunction, although in a very restricted population.Unfortunately, there are no experimental data on the mode of action of melanotan II, as melanotan II is the first α-MSH agonist inducing penile erection when injected peripherally.
Illustration of the proerectile effect of melanotan II (MT-II) in humans. Placebo (A) or MT-II (B, 25 ug/kg and C, 133 ug/kg) was injected subcutaneously in patients and RigiScan recording was performed from 6 h. Apparent erections developed in 8 of 10 men treated with MT-II. (Reproduced with permission from Wessells H et al. Effect of an alphamelanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology 2000; 56:641–646.)

Melanotan II Preparation Products And Raw materials

Raw materials

Preparation Products


Melanotan II Suppliers

Global( 149)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 299 58
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 1954 58
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20602 58
Jinan Tenglong Chemical Co.,Ltd
Whatsapp:+8615563263311 Skype:live:smions7080
smions7080@gmail.com CHINA 43 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2236 58

View Lastest Price from Melanotan II manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-24 Melanotan II
121062-08-6
US $10.00 / G 1G 99% 20kg career henan chemical co
2019-04-08 Melanotan II
121062-08-6
US $5.00-5.00 / g 10 Kg/Bag 99% 200kg Cangzhou Wanyou New Material Technology Co.,Ltd

121062-08-6(Melanotan II)Related Search:


  • AC-NLE-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM
  • AC-NLE-C[+ASP-HIS-DPHE-ARG-TRP-LYS]-NH2
  • [ACETYL-NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MELANOCYTE STIMULATING HORMONE (4-10) AMIDE
  • [ACETYL-NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MSH (4-10) AMIDE
  • (ACETYL-NLE4,ASP5,D-PHE7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE ACETATE SALT
  • MELANOTAN II
  • [N-ACETYL-NLE4,ASP5,D-PHE7,LYS10]-ALPHA-MSH (4-10) AMIDE ASP5-LYS10, CYCLIC LACTAM
  • MTII
  • Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2
  • Melanotan Ц
  • Melanotan 2
  • MalanotanIi
  • Mt-Ii(Melanotan)
  • MelanotanAcetate
  • MT2
  • Melanotan-II(MT-II)
  • Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH2
  • N-Acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide (2->7)-lactam
  • Melanotan Ⅱ Actate
  • MelanotanⅡAcetate
  • (Ac-Nle4,Asp5,D-Phe7,Lys10)-cyclo-a-MSH (4-10) amide
  • AC-NLE-CYCLO(-BETA-ASP-HIS-D-PHE-ARG-TRP-EPSILON-LYS-NH2)
  • AC-NLE-CYCLO[(BETA-D)-HFRW-(EPSILON-K)]-NH2
  • AC-NLE-CYCLO(-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2) ACETATE SALT
  • AC-NLE4-C[ASP5, D-PHE7, LYS10]ALPHA-MSH (4-10)-NH2
  • AC-[NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MSH (4-10)-NH2
  • (AC-NLE4, ASP5, DPHE7, LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE
  • AC-NLE-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2
  • (1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-10-(benzyl)-7-(3-guanidinopropyl)-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaketo-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide
  • (1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-7-[3-(diaminomethylideneamino)propyl]-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaoxo-10-(phenylmethyl)-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide
  • (1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-7-[3-[bis(azanyl)methylideneamino]propyl]-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaoxo-10-(phenylmethyl)-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide
  • MT-Ⅱ
  • Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-α-MSH (4-10) aMide Melanotan II, MTII, BreMelanotide aMide
  • MelanotanII Acetate(MT-2)
  • Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2 (AMide bond Asp5-Lys10)
  • Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-a-MSH (4-10) aMide
  • Melanotan II, MTII, BreMelanotide aMide
  • Melanotan ②
  • Malanotan II Acetate
  • Melanotan II SynonyMs Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2
  • melanotan,Melanotan II
  • Anti-MTNR1B (C-terminal) antibody produced in goat
  • Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2
  • Melanotan II acetate salt
  • Muscarinic Toxin-2 from Dendroaspis angusticeps venom
  • M.W. 1024.19 C50H69N15O9
  • Melanotan II Acetate(MT-II)
  • Ac-Nle4, Asp5, DPhe7, Lys10-Cyclo-a-MSH: 4-10 amide, MTII
  • Melanotan-II Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys-NH2)
  • -
  • 121062-08-6
  • Peptides
  • melatonin receptor 1B
  • melatonin receptor MEL1B
  • Anti-MTNR1B (AB2) antibody produced in rabbit
  • Anti-MTNR1B (AB1) antibody produced in rabbit
  • mt2 melatonin receptor
  • mt2 receptor
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