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Tetramethylthiuram Disulfide

Chemical properties Uses Toxicity Production method Hazards & Safety Information
Tetramethylthiuram Disulfide
Tetramethylthiuram Disulfide structure
CAS No.
137-26-8
Chemical Name:
Tetramethylthiuram Disulfide
Synonyms
TMTD;tmtc;TNTD;Tuex;anles;aules;Heryl;tigam;tm-95;TMTDS
CBNumber:
CB9218792
Molecular Formula:
C6H12N2S4
Formula Weight:
240.43
MOL File:
137-26-8.mol

Tetramethylthiuram Disulfide Properties

Melting point:
156-158 °C(lit.)
Boiling point:
129 °C (20 mmHg)
Density 
1.43
refractive index 
1.5500 (estimate)
Flash point:
89°C
storage temp. 
0-6°C
solubility 
0.0184g/l
form 
solid
Water Solubility 
16.5 mg/L (20 ºC)
Merck 
14,9371
BRN 
1725821
Exposure limits
NIOSH REL: TWA 0.5 mg/m3, IDLH 100 mg/m3; OSHA PEL: 0.5 mg/m3; ACGIH TLV: TWA 5 mg/m3.
InChIKey
KUAZQDVKQLNFPE-UHFFFAOYSA-N
CAS DataBase Reference
137-26-8(CAS DataBase Reference)
NIST Chemistry Reference
Thiram(137-26-8)
EPA Substance Registry System
Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetramethyl-(137-26-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,N
Risk Statements  20/22-36/38-43-48/22-50/53
Safety Statements  26-36/37-60-61
RIDADR  UN 2771/2811
WGK Germany  3
RTECS  JO1400000
Autoignition Temperature 316 °F
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29303000
Hazardous Substances Data 137-26-8(Hazardous Substances Data)
Toxicity LD50 orally in rats: 640 mg/kg (Gaines)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501 Dispose of contents/container to..…

Tetramethylthiuram Disulfide price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 45689 Thiram PESTANAL , analytical standard 137-26-8 250mg $38.6 2018-11-13 Buy
Sigma-Aldrich 43966 Thiram certified reference material, TraceCERT 137-26-8 50mg $130 2018-11-20 Buy
Alfa Aesar B20063 Tetramethylthiuram disulfide, 97% 137-26-8 500g $42.8 2018-11-13 Buy
Alfa Aesar B20063 Tetramethylthiuram disulfide, 97% 137-26-8 100g $15.9 2018-11-13 Buy
Sigma-Aldrich T24201 Tetramethylthiuram disulfide 97% 137-26-8 5g $19.3 2018-11-13 Buy

Tetramethylthiuram Disulfide Chemical Properties,Uses,Production

Chemical properties

pure colorless crystal; no smell; m.p.155~156°C; relative density 1.29; easily soluble in benzene, chloroform (230g/L), acetone (80g/L), carbon disulfide and other organic solvents; slightly soluble in ether and ethanol (<10g/L); insoluble in water (30mg/L); decomposing under acid condition;  industrial products are white or light yellow powder, with a m.p. of more than 146℃.

Uses

1. Tetramethylthiuram Disulfide belongs to protective fungicides of broad spectrum, with a residual effect period of up to 7d or so. It is mainly used for dealing with seeds and soil and preventing powdery mildew, smut and rice seedlings damping-off of cereal crops. It can also be used for some fruit trees and vegetable diseases. For example, dressing seed with 500g of 50% wettable powder can control rice blast, rice leaf spot, barley and wheat smut.
2. As pesticides, Tetramethylthiuram Disulfide is often referred to as thiram and is mainly used for the treatment of seeds and soil and the prevention and controlling of cereal powdery mildew, smut and vegetable diseases. This product, as the super accelerator of natural rubber, synthetic rubber and latex, is often referred to as accelerator TMTD and is the representative of thiuram vulcanization accelerator, accounting for 85% of the total amount of similar products. Accelerator T is also the super accelerator of natural rubber, diene synthetic rubber, Ⅱ, R and EPDM, with the highest utilization rate of all. The vulcanization promoting force of accelerator T is very strong, but, without the presence of zinc oxide, it is not vulcanized at all.
3. Used for the manufacture of cables, wires, tires and other rubber products.
4. Used as the super accelerator of natural rubber, synthetic rubber and latex.
5. Used as the late effect promoter of natural rubber, butadiene rubber, styrene-butadiene rubber and polyisoprene rubber.
6. Used for the pest control of rice, wheat, tobacco, sugar beet, grapes and other crops, as well as for the seed dressing and soil treatment.
7. Tetramethylthiuram Disulfide is suitable for the manufacture of natural rubber, synthetic rubber and latex, and can also be used as curing agent. This product is the second accelerator of thiazole accelerators, which can be used with other accelerators as the continuous vulcanization accelerator.
8. In rubber industry, Tetramethylthiuram Disulfide can be used as the super-vulcanization accelerator, and aften used with thiazole accelerator. It can also be used in combination with other accelerators as the continuous rubber accelerator. For slowly decomposing out of free sulfur at more than 100 ℃, it can be used as curing agent too. Its products have excellent resistance to aging and heat, so it is applicable to natural rubber, synthetic rubber and is mainly used in the manufacture of tires, tubes, shoes, cables and other industrial products. In agriculture, it can be used as fungicide and insecticide, and it can also be used as lubricant additives.
9.  Production methods from dimethylamine, carbon disulfide, ammonia condensation reaction was dimethyl dithiocarbamate, and then by the oxidation of hydrogen peroxide to the finished product.

Toxicity

Acute oral-rat: LD50 780~865mg/kg; Acute oral-mice: LD50 1500~2000mg/kg. Accelerator T has an irritation effect on the human mucous membrane and skin. People long-term exposure to it have allergic reactions while drinking alcohol. Carp LC50 4mg/L.

Production method

The preparation of sodium dimethyl dithiocarbamate(SDD): the reaction of dimethylamine hydrochloride and carbon disulfide in the presence of sodium hydroxide can generate sodium dimethylamino dithiocarbamate . The reaction temperature is 50~55℃ and the pH value is 8~9.
The preparation of thiram: the reaction of SDD (or Diram) and hydrogen peroxide in the presence of sulfuric acid can produce thiram. The reaction temperature is controlled at 10 ℃ below and the end pH value is 3 to 4. Chlorine can also be used instead of hydrogen peroxide and sulfuric acid. The reaction is performed in the sieve tray tower, from the bottom of which the diluted chlorine is introduced and from the top of which 5% sodium solution is sprayed, which is called chlorine-air oxidation method. There are also other methods, such as sodium nitrite oxidation or electrolytic oxidation.

Hazards & Safety Information

Category :Toxic substances
Toxicity classification :  moderate toxicity
Acute Toxicity : Oral-Rat LD50: 560 mg/kg; Oral-mouse LD50: 1250 mg/kg
Stimulation Data: Eye-Rabbit 100 mg/24hours Moderate
Flammability Hazardous characteristics:
The products can decompose into toxic nitrogen oxides and sulfur oxides when meeting heat.
Storage and transportation characteristics :
Storehouse should be low-temperature, well-ventilated and dry; the storage and transportation should be separated form food raw materials.
Extinguishing agent : sand, dry powder, foam
Occupational Standard :TWA 5 mg/m3; STEL 10 mg/m3

Chemical Properties

Thiram is a colorless to yellow, crystalline solid. Characteristic odor. Commercial pesticide products may be dyed blue.

Chemical Properties

white to almost white powder

Uses

antianginal

Uses

Thiram is an ectoparasiticide. Thiram is used in agriculture to prevent fungal diseases in seed and crops. Thiram has other applications ranging from use as a topical bactericide to animal repellent.

Definition

ChEBI: An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.

Uses

Rubber accelerator; vulcanizer; seed disinfectant; fungicide; bacteriostat in soap; animal repellent.

Uses

Seed disinfectant

General Description

A liquid solution of a white crystalline solid. Primary hazard is to the environment. Immediate steps should be taken to limit spread to the environment. Easily penetrates the soil to contaminates groundwater and waterways.

Air & Water Reactions

Insoluble in water. Decomposes in acidic media to give toxic products. Decomposes to an extent on prolonged exposure to heat, air or moisture.

Reactivity Profile

TMTD is incompatible with oxidizing materials and strong acids. Also incompatible with strong alkalis and nitrating agents .

Hazard

Toxic by ingestion and inhalation, irritant to skin and eyes. Body weight and hematologic effects. Questionable carcinogen.

Health Hazard

Inhalation of dust may cause respiratory irritation. Liquid irritates eyes and skin and may cause allergic eczema in sensitive individuals. Ingestion causes nausea, vomiting, and diarrhea, all of which may be persistent; paralysis may develop.

Fire Hazard

Special Hazards of Combustion Products: Toxic and irritating oxides of sulfur are formed. Carbon disulfide may be formed from unburned material.

Agricultural Uses

Fungicide, Rodenticide: Thiram is used as a fungicide to prevent crop damage in the field and to prevent crops from deterioration in storage or transport. Thiram is also used as a seed, nut, fruit, and mushroom disinfectant from a variety of fungal diseases. In addition, it is used as an animal repellent to protect fruit trees and ornamentals from damage by rabbits, rodents, and deer. Thiram has been used in the treatment of human scabies, as a sun screen, and as a bactericide applied directly to the skin or incorporated into soap. Thiram is used as a rubber accelerator and vulcanizer and as a bacteriostat for edible oils and fats. It is also used as a rodent repellent, wood preservative, and may be used in the blending of lubricant oils. Registered for use in EU countries. Registered for use in the U.S.

Trade name

AAPIROL®; AATACK®; AATIRAM®; ACCELERATOR T®; ACCELERATOR THIURAM®; ACCEL TMT®; AGROSOL POUR-ON®; ANLES®; ARASAN®[C]; ATIRAM®; ATTACK®; AULES®; CHIPCO THIRAM 75®; CRYLCOAT®; CUNITEX®; CYURAM DS®; DELSAN®; EBECRYL®; EKAGOM TB®; EVERSHIELD T SEED PROTECTORANT®; FALITIRAM®; FERMIDE®; FERNACOL®; FERNASAN®; FERNIDE®; FLO PRO T SEED PROTECTANT®; FMC 2070®[C]; FORMALSOL®; HERMAL®; HERYL®; HEXATHIR®; HY-VIC®; KODIAK T®; KREGASAN®; LIQUID MOLY-CO-THI®; MERCURAM®; METIURAC®; MOLY-T®; NA2771®; NOBECUTAN®; NOMERSAN®; NORMERSAN®; OPTIMA®; PANORAM 75®; POLYRAM ULTRA®; POMARSOL®; POMARSOL FORTE®; POMASOL®; PRO-GRO®; PURALIN®; RAXIL®; REZIFILM®; ROOTONE®; ROYAL TMTD®; RTUBAYTAN- THIRAM®; RTU FLOWABLE SOYBEAN FUNGICIDE®; SADOPLON®; SOLUCRYL®; SPOTRETE®; SPOTRETE-F®; SQ 1489®; SRANANSF- X®; TERSAN 75®[C]; TERSANTETRAMETHYL DIURANE SULFIDE®; TETRAPOM®; TETRASIPTON®; THIANOSAN®; THILLATE®; THIMAR®; THIMER®; THIOKNOCK®; THIOSAN®; THIOSCABIN®; THIOTEX®; THIOTOX®; THIRAM 75®; THIRAM 80®; THIRAMAD®; THIRAM B®; THIRAMPA®; THIRASAN®; THIULIN®; THIULIX®; THIURAD®; THIURAMIN®; THIURAMYL®; THYLATE®; TIRAMPA®; TITAN FL®; TRAMETAN®; TRIDIPAM®; TRIPOMOL®; TUADS®; TUEX®; TULISAN®; UCECOAT®; UCECRYL®; UVECRYL®; VANCIDA TM-95®; VANCIDE TM®; VITAFLO 280®; VITAVAX® Thiram; VITAVAX-T®; VUAGT-1-4®; VULCAFOR TMTD®; VULKACIT MTIC®; VULKACIT THIURAM®; VULKACIT THIURAM/C®

Contact allergens

TITD is a rubber vulcanization accelerator

Contact allergens

This rubber chemical, accelerator of vulcanization, represents the most commonly positive allergen contained in “thiuram mix.” The most frequent occupational categories are the metal industry, homemakers, health services and laboratories, the building industry, and shoemakers. It is also widely used as a fungicide, belonging to the dithiocarbamate group of carrots, bulbs, and woods, and as an insecticide. Thiram is the agricultural name for thiuram.

Safety Profile

Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic and teratogenic data. Other experimental reproductive effects. Mutation data reported, Affects human pulmonary system. A rmld allergen and irritant. Acute poisoning in experimental animals produced liver, hdney, and brain damage. Dangerous in a fire; see NITROGEN MONOXIDE and SULFUR DIOXIDE.

Potential Exposure

Thiram is a dithiocarbamate. Some thiurams have been used as rubber components: thiram is used as a rubber accelerator and vulcanizer; a seed, nut, fruit, and mushroom disinfectant; a bacteriostat for edible oils and fats; and as an ingredient in suntan and antiseptic sprays and soaps. It is also used as a fungicide, rodent repellent; wood preservative; and may be used in the blending of lubricant oils.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

Environmental Fate

Biological. In both soils and water, chemical and biological mediated reactions can transform thiram to compounds containing the mercaptan group (Alexander, 1981). Odeyemi and Alexander (1977) isolated three strains of Rhizobium sp. that degraded thiram. One of these strains, Rhizobium meliloti, metabolized thiram to yield dimethy- lamine (DMA) and carbon disul?de which formed spontaneously from dimethyldithiocar- bamate (DMDT). The conversion of DMDT to DMA and carbon disul?de occurred via enzymatic and nonenzymatic mechanisms (Odeyemi and Alexander, 1977).
When thiram (100 ppm) was inoculated with activated sludge (30 ppm) at 25°C and pH 7.0 for two weeks, 30% degraded. Metabolites included methionine, elemental sulfur, formaldehyde, dimethyldithiocarbamate-α-aminobutyric acid and the corresponding keto aci
To a non-autoclaved alluvial sandy loam (pH 7.3) fortified and inoculated with the bacterium Pseudomonas aeruginosa, 40 and 86% degradation were observed after 4 and 24 days, respectively. In autoclaved soil, thiram degradation was not affected. Degradat
Soil. Decomposes in soils to carbon disul?de and dimethylamine (Sisler and Cox, 1954; Kaars Sijpesteijn et al., 1977). When a spodosol (pH 3.8) pretreated with thiram was incubated for 24 days at 30°C and relative humidity of 60–90%, dimethylamine formed as the major product. Minor degradative products included nitrite ions (nitration reduction) and dimethylnitrosamine (Ayanaba et al., 1973).
Plant. Major plant metabolites are ethylene thiourea, thiram monosul?de, ethylene thiram disul?de and sulfur (Hartley and Kidd, 1987).

Shipping

UN2771 Thiocarbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Crystallise thiram (three times) from boiling CHCl3, then recrystallise it from boiling CHCl3 by adding EtOH dropwise to initiate crystallisation, and allow it to cool. Finally it is precipitated from cold CHCl3 by adding EtOH (which retains the monosulfide in solution). [Ferington & Tobolsky J Am Chem Soc 77 4510 1955, Beilstein 4 IV 242.]

Incompatibilities

Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine,fluorine, etc.); contact may cause fires or explosions. Keep away from strong alkaline materials, strong acids, strong bases and nitrating agents.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Thiram can be dissolved in alcohol or other flammable solvent and burned in an incinerator with an afterburner and scrubber.

Tetramethylthiuram Disulfide Preparation Products And Raw materials

Raw materials

Preparation Products


Tetramethylthiuram Disulfide Suppliers

Global( 284)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Chemson Industrial (Shanghai) Co., Ltd.
86-21-65208861-ext8007
86-21-65180813 sales1@chemson.com.cn CHINA 121 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Dalian Richfortune Chemicals Co., Ltd
86-411-84820922, 84821539
86-411-84821380 sales@richfortunechem.com China 362 57
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1662 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
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career henan chemical co
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View Lastest Price from Tetramethylthiuram Disulfide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-14 Tetramethylthiuram Disulfide
137-26-8
US $1.00 / kg 1kg as customer's need 100kg career henan chemical co
2018-04-23 Accelerator TMTD TT; Thiram; Bis((dimethylamino) carbonothioyl) disulfide
137-26-8
US $3.90 / KG 25KG 99.50% 1000tons Chemson Industrial (Shanghai) Co., Ltd.

Tetramethylthiuram Disulfide Spectrum


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